HtrA Serine Peptidase 1 (HTRA1) ELISA试剂盒产品概述

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HtrA Serine Peptidase 1 ELISA试剂盒 (HTRA1)
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别名:
AI429470, ARMD7, CARASIL, HTRA, HTRA1, L56, MGC145723, ORF480, Prss11, RSPP11, Xhtra1, zgc:92029, zgc:172061
list all ELISA KIts 基因 基因ID UniProt
HTRA1 5654 Q92743
HTRA1 56213 Q9R118
大鼠 HTRA1 HTRA1 65164 Q9QZK5

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引用最多的HtrA Serine Peptidase 1 ELISA试剂盒

  1. Human HTRA1 ELISA Kit for Sandwich ELISA - ABIN572376 : Marzioni, Lorenzi, Altobelli, Giannubilo, Paolinelli, Tersigni, Crescimanno, Monsurrò, Tranquilli, Di Simone, Castellucci: Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR. in Placenta 2012 (PubMed)
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Zebrafish HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.

Rhesus Monkey HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.

  2. Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR (显示 UTS2R ELISA试剂盒) of ARMS2 (显示 ARMS2 ELISA试剂盒) to be associated with drusen.

  3. As in humans, one variant within LOC387715/ARMS2 (显示 ARMS2 ELISA试剂盒) and one in HTRA1 were significantly associated with age-related macular degeneration.

Human HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Results show that HTRA1 is epigenetically silenced in HCT116 colon carcinoma cells and during early stages of tumorigenesis in a mouse model of intestinal cancer. Downregulation of HTRA1 causes a multiple phenotypes that are hallmarks of cancer cells including increased proliferation of mouse embryonic fibroblasts, as well as chromosome and centrosome amplifications.

  2. High HTRA1 expression is associated with cervical cell proliferation.

  3. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD (显示 AMD1 ELISA试剂盒)) pathogenesis.

  4. Variants in HTRA1 are not associated with age-related macular degeneration.

  5. Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers

  6. FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation

  7. correlation between TGFb1 (显示 TGFB1 ELISA试剂盒) and pSmad2 as well as between HtrA1 and TGFb1 (显示 TGFB1 ELISA试剂盒) and the very significant increase of Ki67 (显示 MKI67 ELISA试剂盒) in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis.

  8. Two synonymous polymorphisms in exon 1 of the HTRA1 gene result in a protein with altered thermophoretic properties.

  9. significant increase of serum HtrA1 in early-onset pre-eclampsia

  10. a frameshift mutation in the HTRA1 gene detected in a CARASIL pedigree resulted in reduced HTRA1 protein and increased TGF-beta1 (显示 TGFB1 ELISA试剂盒) expression, which may cause severe CARASIL and peripheral small arterial disease

Mouse (Murine) HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. transfection of cells with a constitutively active rapamycin-resistant p70S6K (显示 RPS6KB1 ELISA试剂盒) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.

  2. Increased expressions of Tgf-beta1 (显示 TGFB1 ELISA试剂盒), p-Smad2 (显示 SMAD2 ELISA试剂盒)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.

  3. In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (显示 TGFB1 ELISA试剂盒) pathway activation.

  4. HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone

  5. The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (显示 AMD1 ELISA试剂盒)

  6. the inhibitory effect of IFN-gamma (显示 IFNG ELISA试剂盒) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (显示 NCOA5 ELISA试剂盒)) mouse models and in human RA synovial cells.

  7. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

  8. Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (显示 BMP2 ELISA试剂盒)-induced Smad1 (显示 SMAD1 ELISA试剂盒)/5/8, ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and p38 (显示 CRK ELISA试剂盒) phosphorylation in pre-osteoblasts.

  9. This study offers new insights into the regulation of HTRA-1 expression via LPS (显示 TLR4 ELISA试剂盒)/TLR-4 (显示 TLR4 ELISA试剂盒) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.

  10. suggest a critical role for LRP1 (显示 LRP1 ELISA试剂盒) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (显示 CTGF ELISA试剂盒) protein levels.

Xenopus laevis HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.

HtrA Serine Peptidase 1 (HTRA1) 抗原简介

Antigen Summary

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

Alternative names and synonyms associated with HtrA Serine Peptidase 1 (HTRA1)

  • HtrA serine peptidase 1a (htra1a) Elisa Kit
  • HtrA serine peptidase 1 (HTRA1) Elisa Kit
  • HtrA serine peptidase 1b (htra1b) Elisa Kit
  • HtrA serine peptidase 1 (htra1) Elisa Kit
  • Serine protease HTRA1 (htra1) Elisa Kit
  • HtrA serine peptidase 1 (Htra1) Elisa Kit
  • serine protease (HTRA) Elisa Kit
  • AI429470 Elisa Kit
  • ARMD7 Elisa Kit
  • CARASIL Elisa Kit
  • HTRA Elisa Kit
  • HTRA1 Elisa Kit
  • L56 Elisa Kit
  • MGC145723 Elisa Kit
  • ORF480 Elisa Kit
  • Prss11 Elisa Kit
  • RSPP11 Elisa Kit
  • Xhtra1 Elisa Kit
  • zgc:92029 Elisa Kit
  • zgc:172061 Elisa Kit

Protein level used designations for HTRA1

HtrA serine peptidase 1 , high-temperature requirement A serine peptidase 1A , serine protease 11 , serine protease HTRA1A , high-temperature requirement A serine peptidase 1B , serine protease HTRA1B , high temperature required A1 , Serine protease HTRA1 , IGFBP5-protease , high-temperature requirement A serine peptidase 1 , protease, serine, 11 (IGF binding) , serine protease HTRA1 , insulin-like growth factor binding protein 5 protease , protease, serine, 11 (Igf binding) , IGF binding , protease, serine, 11 , protease serine 11 , High-temperature requirement A serine peptidase 1 , Serine protease 11

GENE ID SPECIES
431766 Danio rerio
450792 Pan troglodytes
565082 Danio rerio
705855 Macaca mulatta
780187 Xenopus (Silurana) tropicalis
100064570 Equus caballus
100196695 Salmo salar
100541363 Meleagris gallopavo
100564246 Anolis carolinensis
100583976 Nomascus leucogenys
5654 Homo sapiens
56213 Mus musculus
477852 Canis lupus familiaris
282326 Bos taurus
65164 Rattus norvegicus
496061 Xenopus laevis
100857572 Gallus gallus
100008705 Oryctolagus cuniculus
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