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Human Biglycan ELISA Kit for Sandwich ELISA - ABIN423825
Maishi, Ohba, Akiyama, Ohga, Hamada, Nagao-Kitamoto, Alam, Yamamoto, Kawamoto, Inoue, Taketomi, Shindoh, Hida, Hida: Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan. in Scientific reports 2016
Results identified loss-of-function mutation in BGN gene in patients with an X-linked syndromic form of severe thoracic aortic aneurysms and dissections (TAAD) confirming BGN as causative gene in severe form of TAAD.
After the first year of smoking abstinence the levels of BGN expression and carotid-femoral pulse wave velocity are significantly improved as compared to baseline.
study reports a temporal relationship between altered placental biglycan expression and subsequent development of fetal growth restriction/small for gestational age.
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (p = 0.0008) and Lumican (显示 LUM ELISA试剂盒) (p = 0.01) and lower expression of Decorin (显示 DCN ELISA试剂盒) (p < 0.0001) in urothelial carcinoma of bladder
Mutation in BGN gene is associated with X-Linked Spondyloepimetaphyseal Dysplasia.
biglycan exerts an important role in cell proliferation, migration, invasion and apoptosis in colon cancer.
BGN might play an important role on metastasis in human endometrial cancer and it might be a target marker for the molecular therapy of advanced and recurrence endometrial cancer.
This study demonstrated that the small leucine-rich proteoglycan (显示 Vcan ELISA试剂盒) BGN accumulates in CADASIL (显示 NOTCH3 ELISA试剂盒) and binds to NOTCH3 (显示 NOTCH3 ELISA试剂盒).
Biglycan may have a role in development of vascular damage in smokers
BGN is a factor secreted by peritubular cells to modulate FGFR3c signaling and thus contributes to the regulation of spermatogonial maintenance
Results show that Bgn plays a role in the process of angiogenesis during fracture healing, and that effect appears to be partially mediated through endostatin (显示 COL18A1 ELISA试剂盒) suppression.
Asporin (显示 ASPN ELISA试剂盒) deficiency changes skin glycosaminoglycan composition, and decorin (显示 DCN ELISA试剂盒) and biglycan content, which may explain the changes in skin mechanical properties.
Biglycan plays a protective role during the progression of atherosclerosis in ApoE (显示 APOE ELISA试剂盒)-deficient mice by inhibiting thrombin (显示 F2 ELISA试剂盒) generation.
These genes were concordantly induced by TAC (显示 IL2RA ELISA试剂盒) in WT but not in biglycan KO mice. CONCLUSIONS: Left ventricular pressure overload induces biglycan expression in cardiac fibroblasts. Ablation of biglycan improves cardiac function and attenuates left ventricular hypertrophy and fibrosis after long-term pressure overload.
Importance of biglycan and decorin (显示 DCN ELISA试剂盒) as targets for the manipulation of fetal membrane extracellular matrix stability in the context of inflammation.
Biglycan deficiency leads to loosely packed aortic collagen fibers, increased susceptibility of aortic elastin (显示 ELN ELISA试剂盒) fibers to angII-induced stress, and up-regulation of vascular perlecan (显示 HSPG2 ELISA试剂盒) content.
Biglycan signaling supported fetal membrane remodeling during early gestation in the absence of concomitant changes in TGFbeta (显示 TGFB1 ELISA试剂盒) levels.
Lumican (显示 LUM ELISA试剂盒) and biglycan influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.
Biglycan-triggered TLR-2 (显示 TLR2 ELISA试剂盒)- and TLR-4 (显示 TLR4 ELISA试剂盒)-signaling exacerbates the pathophysiology of ischemic acute kidney injury.
De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88 (显示 MYD88 ELISA试剂盒)/TRIF (显示 RNF138 ELISA试剂盒) pathways.
Data show that biglycan, collagen type I, collagen type II, decorin (显示 DCN ELISA试剂盒), and versican (显示 Vcan ELISA试剂盒) were significantly affected by vibration duration, frequency, and amplitude.
biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes
biglycan-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
The results indicate that CTGF (显示 CTGF ELISA试剂盒) suppresses the synthesis of biglycan but newly induced that of decorin (显示 DCN ELISA试剂盒) in the cells when the cell density is low.
LDL electrostatic interactions with decorin (显示 DCN ELISA试剂盒) and biglycan in the aortic valve leaflets and vascular wall is a major source of LDL retention.
Bgn regulates BMP4 (显示 BMP4 ELISA试剂盒) signaling through modulation of Chordin (显示 CHRD ELISA试剂盒) anti-BMP4 (显示 BMP4 ELISA试剂盒) activity.
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.
, bone/cartilage proteoglycan I
, bone/cartilage proteoglycan-I
, dermatan sulphate proteoglycan I
, small leucine-rich protein 1A
, Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor)
, bone/cartilage proteclycan 1
, leucine-rich PG I