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Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
ur findings suggest that these two families of amines inhibit cystathionine-gamma-lyase (CSE) to varying extents, which directly results in altered levels of intracellular HCY and consequent changes in Human vascular smooth muscle cells proliferation.
Lipopolysaccharide increases the expression of CSE in human macrophages, increasing H2S synthesis, via ERK (显示 EPHB2 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway.
Nox4 (显示 NOX4 ELISA试剂盒) is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.
The expression of CSE was positively correlated with the severity of gastric ulcer
Our study demonstrates that CSE/H2S system is regulated by miR (显示 MLXIP ELISA试剂盒)-216a, and regulates ABCA1 (显示 ABCA1 ELISA试剂盒)-mediated cholesterol efflux and cholesterol levels through the PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) pathway.
Collectively, our findings indicate that radiation could promote HCC (显示 FAM126A ELISA试剂盒) cell invasion through EMT (显示 ITK ELISA试剂盒) mediated by endogenous H2S/CSE signaling via the p38MAPK (显示 MAPK14 ELISA试剂盒) pathway.
3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function.
An increase of placental mRNA levels in the pre-eclampsia group was observed for methionine synthase (显示 MTR ELISA试剂盒) and cystathionine gamma-lyase.
GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
The antiatherosclerotic effect of estrogen is mediated by CSE-generated H2S
Cystathionine-Gamma-Lyase Gene Deletion is associated with reduced inflammation and liver damage.
this study reveals the molecular basis for the differential expression of Cth in mouse models of essential hypertension under basal and pathophysiological conditions.
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS (显示 CBS ELISA试剂盒) or CSE slightly ameliorates the outcome of LPS (显示 TLR4 ELISA试剂盒)-induced endotoxemia in vivo.
lung MPO activity increased following induction of sepsis with CLP while siRNA treatment significantly reduced MPO activity. Liver and lung cytokine and chemokine levels in CLP-induced sepsis reduced following treatment with siRNA. These findings show a crucial pro-inflammatory role for H2S synthesized by CSE in macrophages in sepsis and suggest CSE gene silencing with siRNA as a potential therapeutic approach for this co
H2S augmented the S-sulfhydration of the rate-limiting gluconeogenic enzymes and PGC-1alpha (显示 PPARGC1A ELISA试剂盒) and increased their activities, which were lower in untreated : To investigate the regulation of hepatic glucose production by cystathionine gamma-lyase KO hepatocytes
Endogenous cystathionine gamma-lyase/Hydrogen sulfide regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment
The results of this study suggest that CSE is not critically involved in chronic pain signaling in mice and that sources different from CSE mediate the pain relevant effects of H2S.
CSE-H2S increased PPARgamma (显示 PPARG ELISA试剂盒) activity by direct sulfhydration at the C139 site, thereby changing glucose into triglyceride storage in adipocytes.
Therefore, our data suggest that DNA hypermethylation of CpG rich region in cse promoter might contribute to the decrease of cse transcription and H2S production in macrophages, and thus contribute to atherosclerosis development.
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
, cystathionase (cystathionine gamma-lyase)
, cysteine desulfhydrase
, cysteine-protein sulfhydrase
, homoserine deaminase
, homoserine dehydratase
, CTL target antigen
, probasin-related antigen