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Chen, Teramura, Iwata: Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization. in Biomaterials 2011
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Lim, Joy, Hill, San Brian Chia: Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease. in European journal of medicinal chemistry 2011
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Human Prothrombin ELISA Kit for Sandwich ELISA - ABIN612790
Badimon, Badimon, Turitto, Vallabhajosula, Fuster: Platelet thrombus formation on collagen type I. A model of deep vessel injury. Influence of blood rheology, von Willebrand factor, and blood coagulation. in Circulation 1989
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Mouse (Murine) Prothrombin ELISA Kit for Sandwich ELISA - ABIN2010738
Wang, Braun, Zhang, Norström, Thorlacius: Thrombin generation in abdominal sepsis is Rho-kinase-dependent. in Biochemical and biophysical research communications 2015
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Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (显示 BGN ELISA试剂盒) plays a protective role during the progression of atherosclerosis in ApoE (显示 APOE ELISA试剂盒)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (显示 GP1BA ELISA试剂盒)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (显示 MARK2 ELISA试剂盒) interaction regulated MCP-1 (显示 CPT1B ELISA试剂盒), TF, MCSF (显示 CSF1 ELISA试剂盒) and IL-6 (显示 IL6 ELISA试剂盒) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (显示 SERPINC1 ELISA试剂盒) nanoparticle therapeutics.
Thrombin-PAR1 (显示 F2R ELISA试剂盒) signaling, via nitric oxide and EPCR (显示 PROCR ELISA试剂盒), promotes hematopoietic stem cell (HSC (显示 FUT1 ELISA试剂盒)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (显示 CDC25C ELISA试剂盒) and Ras-associating domains of phospholipase C epsilon (显示 PLCE1 ELISA试剂盒).
thrombin/PAR1 (显示 F2R ELISA试剂盒) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.
The prevalence of FVL (显示 F5 ELISA试剂盒) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (显示 STXBP1 ELISA试剂盒)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (显示 F5 ELISA试剂盒) mutation with ROP (显示 STXBP1 ELISA试剂盒) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (显示 F10 ELISA试剂盒) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
EPCR (显示 PROCR ELISA试剂盒) occupancy recruits G-protein coupled receptor kinase 5 (显示 GRK5 ELISA试剂盒), thereby inducing beta-arrestin-2 (显示 ARRB2 ELISA试剂盒) biased PAR1 (显示 MARK2 ELISA试剂盒) signaling by both APC (显示 APC ELISA试剂盒) and thrombin. In
Data suggest that subtilisin, a serine protease secreted by non-pathogenic bacterium Bacillus subtilis, induces plasma clotting by proteolytically activating prothrombin with single "non-canonical" cleavage at Ala470-Asn471 bond.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII (显示 F8 ELISA试剂盒) by thrombin has been presented.
These studies clarify the role of PKCdelta (显示 PKCd ELISA试剂盒) in endothelial cell cytoskeleton regulation.
Findings indicate functional effects of thrombin allostery and suggest that individual active site-directed thrombin inhibitors uniquely modulate exosite function.
Acute Coronary Syndrome patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (显示 SULF1 ELISA试剂盒) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (显示 SULF1 ELISA试剂盒) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (显示 MAPK1 ELISA试剂盒), MSK1 (显示 RPS6KA5 ELISA试剂盒), and NF-kappaB (显示 NFKB1 ELISA试剂盒) play important roles in thrombin-induced iNOS (显示 NOS2 ELISA试剂盒) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (显示 F2R ELISA试剂盒)) and thereby increasing the sensitivity of the myofilament to Ca(2 (显示 CA2 ELISA试剂盒)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (显示 UGDH ELISA试剂盒) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (显示 F10 ELISA试剂盒) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (显示 UGDH ELISA试剂盒) and by receptor-mediated up-regulation of factor XIII (显示 UGDH ELISA试剂盒) synthesis
In conclusion, thrombin activates pro-MMP-2 (显示 MMP2 ELISA试剂盒) in the absence of elevated pro-MMP-2 (显示 MMP2 ELISA试剂盒) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (显示 MMP2 ELISA试剂盒)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (显示 F2R ELISA试剂盒), RhoA (显示 RHOA ELISA试剂盒), and myocardin (显示 MYOCD ELISA试剂盒).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA