anti-MASP1 (MASP1) 抗体产品概述

Full name:
anti-Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) 抗体 (MASP1)
在www.antibodies-online.cn可供75 Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) 抗体的13不同的供货商。 再加上,我们可以发MASP1 蛋白 (22)MASP1 试剂盒 (19)和数多这个蛋白质的别的产品。 总共124 MASP1产品已列进来了。
别名:
3MC1, AW048060, CCPII, CRARF, CRARF1, MAP1, MAp44, MASP, Masp1/3, MASP3, PRSS5, RaRF
列出全部抗体 基因 基因ID UniProt
MASP1 17174 P98064
MASP1 5648 P48740
MASP1    

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Mouse (Murine) Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) interaction partners

  1. MBL (显示 MBL2 抗体)-KO (Figure 1a) and MASP-1-KO (Figure 1b) mice are poor mobilizers in response to mobilizing agents compared with WT littermates

  2. this study shows that inhibition of MASP-1/3 by gene silencing is sufficient to ameliorate collagen Ab-induced arthritis in mice

  3. MASP-1 plasma levels were higher among patients with type 2 diabetes and diabetic mice

  4. study provides conclusive evidence that an intact complement LP is essential to initiate CAIA, and that MAp44 may be an appropriate treatment for inflammatory arthritis.

  5. Data indicate that co-deficiency of factor H (FH (显示 CFH 抗体)) and MASP-1/MASP-3 did not ameliorate either the plasma Complement C3 (显示 C3 抗体) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

  6. Within the mannose-binding lectin (显示 MBL2 抗体)/MASP complex, MASP-1 is the necessary complement component for thrombin (显示 F2 抗体)-like activity in vitro.

  7. We conclude that MASP-1 does not require binding to mannose binding lectins or ficolins to activate the alternative pathway of complement

  8. we investigated the mechanism of MASP-3 activation and its substrate using the recombinant mouse MASP-3 (rMASP-3) and several different types of MASP-deficient mice

  9. Our studies demonstrate for the first time, to our knowledge, the absolute requirement for the activity of MASP-1 protein in autoimmune-associated inflammatory tissue injury

  10. MASP-1 converted pro-Df to the active form in vitro, although the activation mechanism of pro-Df by MASP-1 is still unclear. Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways.

Human Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) interaction partners

  1. Our finding suggests that complement MASP-1 can increase adhesion between neutrophils and endothelial cells in a direct fashion

  2. Study discovered novel and independent associations of prediabetes and related traits with MASP1, and some evidence for associations with THBS1 (显示 THBS1 抗体), GPLD1 (显示 GPLD1 抗体) and ApoA-IV (显示 APOA4 抗体), suggesting a role for these proteins in the pathophysiology of type 2 diabetes.

  3. MASP-1 plasma levels were higher among patients with type 2 diabetes and diabetic mice

  4. MASP-1 was not associated with adverse cardiovascular outcomes in diabetics.

  5. high serum CL-L1 (显示 COLEC10 抗体) concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration

  6. The exclusion of the MASP1 and COLEC11 (显示 COLEC11 抗体) Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome

  7. Plasma MASP-1 concentration at the early stage of Kawasaki disease is predictive of length of time of recovery from coronary artery lesions.

  8. MASP-1 and MASP-2 (显示 MASP2 抗体) are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation.

  9. described for the first time a detailed model of prothrombin (显示 F2 抗体) activation by MASP-1

  10. Fusion of MAP-1 with FH domains represents a novel therapeutic approach for selective targeting upstream and central complement activation at sites of inflammation

MASP1 抗原简介

Antigen Summary

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MASP1

  • mannan-binding lectin serine peptidase 1 (Masp1) 抗体
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1) 抗体
  • 3MC1 抗体
  • AW048060 抗体
  • CCPII 抗体
  • CRARF 抗体
  • CRARF1 抗体
  • MAP1 抗体
  • MAp44 抗体
  • MASP 抗体
  • Masp1/3 抗体
  • MASP3 抗体
  • PRSS5 抗体
  • RaRF 抗体

Protein level used designations for MASP1

MASP-1 , complement factor MASP-3 , complement-activating component of Ra-reactive factor , mannan-binding lectin serine protease 1 , mannose-binding lectin-associated serine protease 1 , mannose-binding protein-associated serine protease , ra-reactive factor serine protease p100 , raRF , serine protease 5 , Ra-reactive factor serine protease p100

GENE ID SPECIES
17174 Mus musculus
5648 Homo sapiens
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