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In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC (显示 FAM126A ELISA试剂盒) and better survival.
Preeclamptic plasma induces transcription modifications involving the AP-1 (显示 FOSB ELISA试剂盒) transcriptional regulator JDP2 in endothelial cells.
Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
the recruitment of multiple HDAC (显示 HDAC3 ELISA试剂盒) members to JDP2 and ATF3 (显示 ATF3 ELISA试剂盒) is part of their transcription repression mechanism.
The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
JDP2 is crucial to triggering reactivation from latency to lytic replication
JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival.
c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene
JDP2 is a cellular survival protein whose presence is necessary for normal cellular function
JDP2 acts as a repressor and could be functionally associated with HDAC3 (显示 HDAC3 ELISA试剂盒) to inhibit CHOP (显示 DDIT3 ELISA试剂盒) transcription
Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH (显示 BRD2 ELISA试剂盒) and higher expression of the Fshb (显示 FSHB ELISA试剂盒) subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles
JDP2 acts as a novel transcriptional activator of the mouse Mc2r (显示 MC2R ELISA试剂盒) gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R (显示 MC2R ELISA试剂盒)-mediated steroidogenesis as well as cell signaling in adrenal glands.
High JDP2 expression in the bone marrow contributes to metastatic spread in the lung.
results suggest a negative feedback loop between JDP2 and p53 (显示 TP53 ELISA试剂盒), and a direct link between JDP2 and a key oncogenic pathway
Tbx3 (显示 TBX3 ELISA试剂盒) plays an important role in osteoclastogenesis at least in part by regulating CSF1 (显示 CSF1 ELISA试剂盒)-dependent expression of JDP2.
Using transgenic mice overexpressing the AP-1 (显示 JUN ELISA试剂盒) inhibitor JDP2, a central role of AP-1 (显示 JUN ELISA试剂盒) in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated.
Jdp2 transcriptionally regulates the Trp53 (显示 TP53 ELISA试剂盒) promoter, via an atypical AP-1 (显示 JUN ELISA试剂盒) site, and Jdp2 expression negatively regulates Trp53 (显示 TP53 ELISA试剂盒) expression levels; a genetic mechanism for tumour formation in the context of Trp53 (显示 TP53 ELISA试剂盒) heterozygosity
Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation.
JDP2 phosphorylation by JNK (显示 MAPK8 ELISA试剂盒) results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli
the kinase fragment of DCLK (显示 DCLK2 ELISA试剂盒) is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Jun dimerization protein 2
, jun dimerization protein 2
, progesterone receptor co-activator
, c-Jun dimerization protein 2