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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305077
Feng, Tang, Chang, Wilson: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages. in Biochemical and biophysical research communications 1993
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988022
Larson, Hübner, Torrero, Morris, Brankin, Swierczewski, Davies, Vonakis, Mitre: Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2012
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988023
Yang, Hirose, Takahashi, Kawakatsu, Takaiwa: Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site. in Plant biotechnology journal 2012
this study shows association of interleukin-10 polymorphisms with risk factors of Alzheimer's disease and other dementias in a Mexican population
Dysfunction of CD24 (显示 CD24 蛋白)+CD38+ B cells in patients with Hashimoto's thyroiditis is associated with a lack of interleukin 10
IL-10, IL-17 (显示 IL17A 蛋白) and IP-10 (显示 CXCL10 蛋白) response to tubercular antigens act as potent discriminative markers for active tuberculosis among pulmonary tuberculosis suspects.
In the present study, we comprehensively investigated the variants in introns, UTRs, and the promoter region of IL10 and identified no association between any of these variants and Vogt-Koyanagi-Harada (VKH) disease.
Results show that IL-10-driven metabolic rheostat maintains metabolic equilibrium during M1 macrophage differentiation and that perturbation of this regulatory loop, either directly by exogenous cellular sources of IL-10 or indirectly via limitations in glucose availability, skews the cellular metabolic program altering the balance between inflammatory and immunosuppressive phenotypes.
Results from these two large randomized aerobic exercise intervention trials suggest that aerobic exercise does not alter IL-10 or IL-4 (显示 IL4 蛋白) in a manner consistent with chronic disease and cancer prevention.
IL-2 (显示 IL2 蛋白) and IL-10 could work synergistically to improve the survival, proliferation, and cytotoxicity of activated CD8 (显示 CD8A 蛋白)(+) T cells, an effect suppressible by CD4 (显示 CD4 蛋白)(+)CD25 (显示 IL2RA 蛋白)(+) Treg cells
Patients with Mycoplasma pneumoniae pneumonia had lower interleukin-10 levels than patients with respiratory syncytial virus pneumonia who had interleukin-10 levels comparable to those of patients with bacterial pneumonia, indicating a significant difference in the interleukin-6 (显示 IL6 蛋白)/interleukin-10 ratio between patients with Mycoplasma pneumoniae pneumonia and respiratory syncytial virus pneumonia.
These findings provide evidence supporting the role of PTX3 (显示 PITX3 蛋白) as a mediator of the anti-inflammatory response in physiologically relevant conditions, and suggests that PTX3 (显示 PITX3 蛋白) counter regulates the development of atherosclerosis by enhancing the production of IL-10.
Single nucleotide polymorphism in IL10 gene is associated with susceptibility to HPV-16 positive cervical cancer.
this study shows that Influenza A virus-induced release of IL-10 inhibits the anti-microbial activities of invariant natural killer T cells during invasive pneumococcal superinfection
Data show that two functionally distinct cytokines, interleukin-4 (IL-4 (显示 IL4 蛋白)) and interferon-gamma (IFN-gamma (显示 IFNG 蛋白)), significantly potentiate the ability of mesenchymal stem cells (MSCs) to inhibit interleukin-10 (IL-10) production by activated regulatory B cells (Bregs).
The anti-inflammatory functions of p38 MAPK (显示 MAPK14 蛋白) in macrophages are critically dependent on production of IL-10.
Pretreating mice with carrageenan once a day before injecting LPS (显示 TLR4 蛋白) increased the levels of IL-10 by 2.5-fold and reduced TNF-alpha (显示 TNF 蛋白) production by 2-fold compared with control. So, kappa/beta-carrageenan alone and in combination with LPS (显示 TLR4 蛋白) enhanced the cellular activity and mobility of peritoneal macrophages by increasing cell adhesion and migration compared with control.
results demonstrate that IL-10-producing interstitial macrophages negatively regulate Th2- and Th17-mediated inflammatory responses, helping prevent neutrophilic asthma
Antigen targeting to DEC-205 (显示 LY75 蛋白) on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 (显示 CXCR3 蛋白) expression on differentiated antigen-specific Th1 (显示 HAND1 蛋白) cells in vivo. This downregulation interferes with the migration of Th1 (显示 HAND1 蛋白) cells into the gut (显示 GUSB 蛋白) and protects mice against severe acute and relapsing intestinal inflammation.
The investigation of the IL-10R complex revealed that both the extracellular and intracellular domains of IL-10R2 (显示 IL10RB 蛋白) influence the conformation of IL-10R1 (显示 IL10RA 蛋白) and that both domains were required for transducing IL-10 signals.
identification of the Mediator-associated kinase CDK8 (显示 CDK8 蛋白), and its paralog CDK19 (显示 CDK19 蛋白), as negative regulators of IL-10 production during innate immune activation
ablation of IL-10 signaling in Th2 cells led to enhanced Th2 cell survival and exacerbated pulmonary inflammation in a murine model of house dust mite allergy
Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (显示 TLR4 蛋白) like receptor activation.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (显示 SOCS3 蛋白), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (显示 TH1L 蛋白) biased, interferon-gamma (显示 IFNG 蛋白) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6 (显示 IL6 蛋白):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (显示 IL6 蛋白), IL-10 and TNF-alpha (显示 TNF 蛋白), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
ICAM1 (显示 ICAM1 蛋白) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (显示 JUN 蛋白) may be responsible for this upregulation.
The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (显示 TGFB1 蛋白), IL-10, and IL-6 (显示 IL6 蛋白) in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (显示 IFNG 蛋白)+CD4 (显示 CD4 蛋白)+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (显示 MAPK14 蛋白) activation.
Boar seminal plasma contained TGF- beta1 (显示 TGFB1 蛋白) and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha (显示 TNF 蛋白) and IL-10, but not IL-6 (显示 IL6 蛋白), are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP (显示 CRP 蛋白) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (显示 NTS 蛋白), which may contribute to differences in the clinical presentation of NTS (显示 NTS 蛋白) infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (显示 TNF 蛋白) cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor