IL-10 蛋白 (IL10)产品概述

Full name:
Interleukin 10 蛋白 (IL10)
在www.antibodies-online.cn可供186 Interleukin 10 (IL10) 蛋白的23不同的供货商。 再加上,我们可以发IL-10 抗体 (690)IL-10 试剂盒 (312)和数多这个蛋白质的别的产品。 总共1213 IL-10产品已列进来了。
列出全部蛋白 基因 基因ID UniProt
IL10 3586 P22301
IL10 16153 P18893
大鼠 IL10 IL10 25325 P29456


按照种类IL-10 蛋白 (IL10)


引用最多的IL-10 蛋白

  1. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2666701 : Asadullah, Sterry, Volk: Interleukin-10 therapy--review of a new approach. in Pharmacological reviews 2003 (PubMed)
    Show all 6 references for 2666701

  2. Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073 : Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992 (PubMed)
    Show all 4 references for 1305073

  3. Cat (Feline) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2008820 : Yoon, Jones, Logsdon, Walter: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. in Structure (London, England : 1993) 2005 (PubMed)
    Show all 3 references for 2008820

  4. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418 : van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 3 references for 413418

  5. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2003641 : Gesser, Leffers, Jinquan, Vestergaard, Kirstein, Sindet-Pedersen, Jensen, Thestrup-Pedersen, Larsen: Identification of functional domains on human interleukin 10. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 2 references for 2003641

  6. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072 : Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 2 references for 1305072

  7. Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2009133 : Cui, Feng, Wang, Zhao: [Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10]. in Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2011 (PubMed)


Human Interleukin 10 (IL10) interaction partners

  1. upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (显示 CXCR4 蛋白) via phosphorylation of S339-CXCR4 (显示 CXCR4 蛋白) in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2 (显示 IL2 蛋白)), IL-4 (显示 IL4 蛋白), and IL-10 messenger RNA (mRNA) transcripts.

  2. This study presents preliminary evidence for the association between IFN +874 T/A, T/T, IL-10 -1082 A/G genotypes, and hemophagocytic lymphohistiocytosis susceptibility in Chinese children

  3. The aim of the present study was to detect antibodies against Epstein-Barr virus and explore the levels of TGFbeta (显示 TGFB1 蛋白) and IL-10 in Polish gastric cancer patients.

  4. This study demonstrated that Il-10 was elevated in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.

  5. The results of the current Turkish study indicate that IL-6 (显示 IL6 蛋白) and IL-10 genotypes seem to be associated with aggressive periodontitis. Also, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis subjects with carrying NF-kappaB1 (显示 NFKB1 蛋白) ins/ins (显示 INS 蛋白) genotypes.

  6. Interferon-alpha-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors.

  7. The results of this study showed lack of association with schizophrenia was detected for IL10 and IL10RA (显示 IL10RA 蛋白) single polymorphisms and haplotypes.

  8. modulation of the expression of VDR (显示 CYP27B1 蛋白) can regulate the expression of IL-10 in peripheral B cells of pituitary gland tumour (PGT (显示 SLCO2A1 蛋白))patients, which may contribute to the treatment of PGT (显示 SLCO2A1 蛋白).

  9. IL-10 592A/C and 819T/C promoter polymorphisms confer susceptibility to advanced endometriosis. No associations were found between the IL-10 1082A/G polymorphism and susceptibility to advanced endometriosis.

  10. Some IL10 tagSNPs were associated with lower- and higher-grade Prostate cancer.

Mouse (Murine) Interleukin 10 (IL10) interaction partners

  1. The defective IL-10 production by PGRN (显示 GRN 蛋白)-deficient cells is primarily due to reduced C/EBPalpha (显示 CEBPA 蛋白) protein stability via the E3 ubiquitin-conjugating enzyme (显示 Ube2t 蛋白) E6AP (显示 ube3a 蛋白) and proteasome-mediated degradation.

  2. IL-6 (显示 IL6 蛋白) directly increases IL-10 production and participates in the counter-inflammatory response after acute kidney injury.

  3. This study reveals the striking ability of a prototypical innate immune receptor to trigger a potent and suppressive IL-10 response in effector/memory T cells, supporting the notion that TLR2 is a co-regulatory receptor on T cells.

  4. data reveal that, despite the multiple immune sources of IL-10 during M. tuberculosis infection, activated effector T cells are the major source accounting for IL-10-induced TB susceptibility.

  5. this study shows that Etv5 (显示 ETV5 蛋白) plays a crucial role in regulating IL-10 production in Th2 cells by facilitating the binding of IL-10-inducing transcription factors at the Il10 locus

  6. FXR (显示 NR1H4 蛋白) activation ameliorated central nervous system autoimmunity in an IL-10-dependent fashion and even suppressed advanced clinical disease upon therapeutic administration

  7. The results indicate that the disease-preventing effects of Bacteroides fragilis in acute dextran sulfate sodium-induced colitis may occur through the TLR2/IL-10 signal pathway.

  8. the results of this study demonstrate that induction of IL-10 has a major influence on disease outcome during acute Staphylococcus aureus infection

  9. IL-10(+) CD8 (显示 CD8A 蛋白)(+) T cells induced by systemic inflammation to infiltrate the liver have initiated an inflammatory, rather than regulatory, program and may thus have a pathogenic role in severe, acute hepatitis.

  10. IL-10 regulates a fibroblast-specific formation of a regenerative, hyaluronan-rich wound extracellular matrix via STAT3 (显示 STAT3 蛋白) signaling.

Cow (Bovine) Interleukin 10 (IL10) interaction partners

  1. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

  2. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

  3. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (显示 TLR4 蛋白) like receptor activation.

  4. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (显示 SOCS3 蛋白), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) interaction partners

  1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

  2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (显示 TH1L 蛋白) biased, interferon-gamma (显示 IFNG 蛋白) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

  3. serum IL-6 (显示 IL6 蛋白):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

  4. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (显示 IL6 蛋白), IL-10 and TNF-alpha (显示 TNF 蛋白), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Guinea Pig Interleukin 10 (IL10) interaction partners

  1. The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.

Rabbit Interleukin 10 (IL10) interaction partners

  1. ICAM1 (显示 ICAM1 蛋白) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (显示 JUN 蛋白) may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) interaction partners

  1. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.

  2. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

  3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (显示 TGFB1 蛋白), IL-10, and IL-6 (显示 IL6 蛋白) in ovarian follicles are reported.

  4. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (显示 IFNG 蛋白)+CD4 (显示 CD4 蛋白)+ regulatory T cells to control transplant arteriosclerosis.

  5. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (显示 MAPK14 蛋白) activation.

  6. Boar seminal plasma contained TGF- beta1 (显示 TGFB1 蛋白) and IL-10 but with high individual variation.

  7. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

  8. These results suggest that TNF-alpha (显示 TNF 蛋白) and IL-10, but not IL-6 (显示 IL6 蛋白), are involved in the late reparatory phases of the experimental disk lesion.

  9. The present study shows that elevated levels of serum CRP (显示 CRP 蛋白) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

  10. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

Rhesus Monkey Interleukin 10 (IL10) interaction partners

  1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (显示 NTS 蛋白), which may contribute to differences in the clinical presentation of NTS (显示 NTS 蛋白) infection in the setting of malaria.

  2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

  3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (显示 TNF 蛋白) cytokine production.

蛋白简介IL-10 (IL10)


The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Alternative names and synonyms associated with IL-10 (IL10)

  • interleukin 10 (IL10)
  • interleukin 10 (Il10)
  • CSIF 蛋白
  • GVHDS 蛋白
  • Il-10 蛋白
  • IL10A 蛋白
  • IL10X 蛋白
  • TGIF 蛋白

Protein level used designations for Interleukin 10 蛋白 (IL10)

T-cell growth inhibitory factor , cytokine synthesis inhibitory factor , interleukin-10 , CSIF , IL-10 , uncharacterized protein LOC100715618 , Cytokine synthesis inhibitory factor , Interleukin-10

3586 Homo sapiens
16153 Mus musculus
25325 Rattus norvegicus
281246 Bos taurus
100034187 Equus caballus
443342 Ovis aries
403628 Canis lupus familiaris
428264 Gallus gallus
100860746 Capra hircus
100715618 Cavia porcellus
100008701 Oryctolagus cuniculus
397106 Sus scrofa
493683 Felis catus
694931 Macaca mulatta
100386149 Callithrix jacchus
469657 Pan troglodytes
101271889 Orcinus orca
IL-10 蛋白 (IL10) 精选生产商