SMAD4 (SMAD4) ELISA试剂盒产品概述

Full name:
SMAD Family Member 4 ELISA试剂盒 (SMAD4)
在www.antibodies-online.cn可供41 SMAD Family Member 4 (SMAD4) ELISA试剂盒的14不同的供货商。 再加上,我们可以发SMAD4 抗体 (187)SMAD4 蛋白 (22)和数多这个蛋白质的别的产品。 总共271 SMAD4产品已列进来了。
别名:
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha

适于 SMAD4 相互作用对的更多 ELISA 试剂盒

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. Genetic status of DPC4 contributes to the recurrence patterns in pancreatic ductal adenocarcinoma following pancreatectomy, and patients with an initially expressed DPC4 gene receive a greater benefit from intensive local control for locoregional recurrence

  2. NK cells from a SMAD4-deficient person affected by polyposis were hyper-responsive to TGF-beta

  3. SMAD4 mutation was commonly detected in pancreatic juice samples from patients with Pancreatic Ductal Adenocarcinoma, mutant SMAD4 concentrations could distinguish PDAC from Intraductal Papillary Mucinous neoplasm.

  4. Phosphorylation of SMAD4 is associated with Breast Cancer Metastasis.

  5. Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG (显示 ENG ELISA试剂盒), two in BMPR1A (显示 BMPR1A ELISA试剂盒), one in PTEN, and one in SMAD4. Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.

  6. Expression levels of Smad4 and miR (显示 MLXIP ELISA试剂盒)-34a in colorectal cancer patients had a significant inverse correlation and overexpressing miR (显示 MLXIP ELISA试剂盒)-34a inhibited macroautophagy activation by directly targeting Smad4 through the TGF-beta (显示 TGFB1 ELISA试剂盒)/Smad4 pathway.

  7. MAD4 (显示 MXD4 ELISA试剂盒) has been found to regulate epithelial-mesenchymal transition, co-immunopurification, and glutathione S-transferase (显示 GSTa2 ELISA试剂盒) pull-down analysis demonstrated that USP17 interacted with SMAD4. Furthermore, USP17 stabilized SMAD4 through its deubiquitinase activity. In conclusion, this study shows that USP17 enhances osteosarcoma cell proliferation and invasion through stabilizing SMAD4.

  8. Upon SMAD4 deletion, we detected high expression levels of FYN (显示 FYN ELISA试剂盒) in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype

  9. our data suggest that miR (显示 MLXIP ELISA试剂盒)-1285-5p functions as a tumor promoter in the development of non-small-cell lung carcinoma by targeting Smad4 and CDH1 (显示 CDH1 ELISA试剂盒), indicating a novel therapeutic strategy for non-small-cell lung carcinoma patients.

  10. SENP1 (显示 SENP1 ELISA试剂盒) deSUMOylated SMAD4 to promote EMT (显示 ITK ELISA试剂盒) via up-regulating E-cadherin (显示 CDH1 ELISA试剂盒) in prostate cancer cells. Therefore, SENP1 (显示 SENP1 ELISA试剂盒) is a potential target for treatment of advanced prostate cancer.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. In SMAD4 deficiency, NK cells unexpectedly acquired an innate lymphoid cell type 1-like gene signature and were unable to control tumor metastasis or viral infection. Mechanistically, SMAD4 restrained non-canonical TGF-beta (显示 TGFB1 ELISA试剂盒) signaling mediated by the cytokine receptor (显示 LEPR ELISA试剂盒) TGFbetaR1 in NK cells.

  2. The effect of Smad4 was at least partially mediated by the downstream effectors Syk (显示 SYK ELISA试剂盒) and ROCK2 (显示 ROCK2 ELISA试剂盒) transcription in megakaryocytes

  3. deletion of Smad4 in OBs (显示 LEP ELISA试剂盒) differentially modulates HSC (显示 FUT1 ELISA试剂盒) fate in a stage-dependent manner

  4. Data suggest that ovarian Bmp4 (显示 BMP4 ELISA试剂盒) levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 (显示 BMP4 ELISA试剂盒) expression via activation of androgen receptors; Smad4 signaling rather than p38 MAPK (显示 MAPK14 ELISA试剂盒) pathway regulates androgen and estrogen formation.

  5. The authors demonstrated that ubiquitin-specific protease (USP) 4 (显示 USP4 ELISA试剂盒) strongly induces activin (显示 Actbeta ELISA试剂盒)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4.

  6. SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells.

  7. Smad4 is necessary for the activation of the mineralization-related genes, it is dispensable for BMP2 (显示 BMP2 ELISA试剂盒) to induce the protein anabolism signature, which instead critically depends on the transcription factor Atf4 (显示 ATF4 ELISA试剂盒).

  8. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (显示 VEGFC ELISA试剂盒) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  9. MZF1 has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.

  10. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Activated TGF-beta (显示 TGFB1 ELISA试剂盒) signaling rescued miR (显示 MYLIP ELISA试剂盒)-143-reduced FSHR (显示 FSHR ELISA试剂盒) and intracellular signaling molecules, and miR (显示 MYLIP ELISA试剂盒)-143-induced porcine granulosa cell apoptosis.

  2. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  3. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (显示 BRD2 ELISA试剂盒).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (显示 FST ELISA试剂盒) are SMAD4 dependent.

  2. ALK5 (显示 TGFBR1 ELISA试剂盒) and Smad4 have roles in TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (显示 TGFB1 ELISA试剂盒) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 抗原简介

Antigen Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4) Elisa Kit
  • Smad4 protein (smad4) Elisa Kit
  • mothers against decapentaplegic homolog 4 (LOC100342294) Elisa Kit
  • SMAD family member 4 (Smad4) Elisa Kit
  • SMAD family member 4, gene 1 (smad4.1) Elisa Kit
  • AW743858 Elisa Kit
  • D18Wsu70e Elisa Kit
  • dpc4 Elisa Kit
  • jip Elisa Kit
  • madh4 Elisa Kit
  • MYHRS Elisa Kit
  • smad4 Elisa Kit
  • Xsmad4 Elisa Kit
  • xsmad4a Elisa Kit
  • XSmad4alpha Elisa Kit

Protein level used designations for SMAD4

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

GENE ID SPECIES
701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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