CDK5 (CDK5) ELISA试剂盒产品概述

Full name:
Cyclin-Dependent Kinase 5 ELISA试剂盒 (CDK5)
在www.antibodies-online.cn可供50 Cyclin-Dependent Kinase 5 (CDK5) ELISA试剂盒的13不同的供货商。 再加上,我们可以发CDK5 抗体 (241)CDK5 蛋白 (19)和数多这个蛋白质的别的产品。 总共323 CDK5产品已列进来了。
别名:
AW048668, cdk5, CG8203, Crk6, DmCdk5, Dmel\\CG8203, PSSALRE, zgc:101604

适于 CDK5 相互作用对的更多 ELISA 试剂盒

Human Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. CRM1 (显示 XPO1 ELISA试剂盒) and CDK5 co-expression was an independent prognostic factors for gastric cancer (GC). Combined CRM1 (显示 XPO1 ELISA试剂盒) and CDK5 expression could provide a prognostic model for overall survival of GC.

  2. Studies indicate evidence for cyclin dependent kinase 5 (CDK5) in contributing to the onset and progression of tumorigenesis.

  3. this study revealed the functional and mechanistic links between CDK5 and the oncogenic ERK5 (显示 MAPK7 ELISA试剂盒)-AP-1 (显示 FOSB ELISA试剂盒) signaling pathway in the pathogenesis of colorectal cancer.

  4. the silencing of Cyclin-dependent kinase 5 preventing memory dysfunction

  5. Increased CDK5 expression is associated with breast cancer.

  6. It is shown that p5 binds the kinase at the same CDK5/p25 (显示 LCN2 ELISA试剂盒) and CDK5/p35 (显示 ANXA1 ELISA试剂盒) interfaces, and is thus a non-selective competitor of both activators, in agreement with available experimental data in vitro.

  7. the activated CDK5 kinase is involved in the EZH2 (显示 EZH2 ELISA试剂盒) phosphorylation that is required for FBW7 (显示 FBXW7 ELISA试剂盒)-mediated degradation.

  8. we supposed that EphA4 (显示 EPHA4 ELISA试剂盒) interacted with CDK5 and promoted its expression which in turn enhanced p-AKT (显示 AKT1 ELISA试剂盒) expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.

  9. the minor allele of CDK5R1 (显示 CDK5R1 ELISA试剂盒) 3'-UTR (显示 UTS2R ELISA试剂盒) rs735555 polymorphism was associated with increased risk for NS-ID. In conclusion, our data suggest that mutations and polymorphisms in CDK5 and CDK5R1 (显示 CDK5R1 ELISA试剂盒) genes may contribute to the onset of the NS-ID phenotype

  10. CDK5 was dynamically modified with O-GlcNAc (显示 OGT ELISA试剂盒) in response to neuronal activity and that glycosylation represses CDK5-dependent apoptosis by impairing its association with p53 (显示 TP53 ELISA试剂盒) pathway.

Mouse (Murine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. Silencing of CDK5 increased BDNF (显示 BDNF ELISA试剂盒) expression, temporarily increased phosphorylation of CaMKII (显示 CAMK2G ELISA试剂盒), ERK (显示 EPHB2 ELISA试剂盒), and CREB (显示 CREB1 ELISA试剂盒); and facilitated calcium signaling in neurites. Together, these data suggest that CDK5 downregulation induces synaptic plasticity in mature neurons involving Ca(2 (显示 CA2 ELISA试剂盒)+) signaling and BDNF (显示 BDNF ELISA试剂盒)/CREB (显示 CREB1 ELISA试剂盒) activation.

  2. we report a key role for Cdk5 activity in the development of allogeneic T-cell responses after allogeneic hematopoietic cell transplantation

  3. Cdk5 regulates axon outgrowth through the GRAB-mediated Rab8-Rab11 cascade.

  4. these results show that Cdk5-mediated phospho-regulation of Foxo3 (显示 FOXO3 ELISA试剂盒) can activate several genes that promote neuronal death and aberrant Abeta (显示 APP ELISA试剂盒) processing, thereby contributing to the progression of neurodegenerative pathologies.

  5. In this study, we discovered that selective upregulation of p39 (显示 ATP6V0D1 ELISA试剂盒) is the underlying mechanism that accommodates the increased functional requirement of Cdk5 activation during neuronal differentiation. In addition, we demonstrated that p39 (显示 ATP6V0D1 ELISA试剂盒) selectively directs Cdk5 to phosphorylate protein substrates essential for axonal development, dendritic spine formation, and synaptogenesis. Moreover, our studies suggest opposing roles o

  6. It suggests that ectopic increase of Cdk5 kinase activity through conversion of p35 to p25 is involved in the process of neuronal death induced by hypoxia.

  7. The behavioral and molecular data indicated that TRPV1 (显示 TRPV1 ELISA试剂盒) is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/threonine406(rat).

  8. that Cdk5-dependent activation of neuronal inflammasomes was involved in the progression of Parkinson's disease

  9. we demonstrate that Cdk5 phosphorylates collapsin response mediator protein 2 (CRMP2 (显示 DPYSL2 ELISA试剂盒)) in the dendritic spines of cultured hippocampal neurons and in vivo in the mouse brain. When we eliminated CRMP2 (显示 DPYSL2 ELISA试剂盒) phosphorylation in CRMP2 (显示 DPYSL2 ELISA试剂盒)(KI/KI (显示 AXIN1 ELISA试剂盒)) mice, the densities of dendritic spines significantly decreased in hippocampal CA1 (显示 CA1 ELISA试剂盒) pyramidal neurons in the mouse brain.

  10. Results indicate that dendritic spine formation and neuronal maintenance are dependent on Cdk5 activity

Cow (Bovine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. data indicate that PP1alpha (显示 PPP1CA ELISA试剂盒) is a downstream target of the NGF (显示 NGFB ELISA试剂盒)/Egr-1 (显示 EGR1 ELISA试剂盒)/Cdk5 pathway during NGF (显示 NGFB ELISA试剂盒)-induced differentiation of PC12 cells and suggest that PP1 (显示 PPYR1 ELISA试剂盒) phosphorylation promotes neuronal differentiation

Pig (Porcine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. CDK5-mediated hyperphosphorylation of SIRT1 (显示 SIRT1 ELISA试剂盒) facilitates the development of endothelial senescence and atherosclerosis.

  2. CDK5 mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 (显示 CDK5R1 ELISA试剂盒) was observed in both cerebral cortex and cerebellum at two months of age

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These data show that Cdk5 regulates the onset and extent of remodeling of the Drosophila mushroom body.

  2. The CDK5 phosphorylates MEKK1 (显示 MAP3K1 ELISA试剂盒), and together, they activate the JNK (显示 MAPK8 ELISA试剂盒) pathway for apoptosis.

  3. The data of this study demonstrated that Cdk5/p35 (显示 RPLP0 ELISA试剂盒) kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila.

  4. Therefore, we propose that Abl and p35/p25 (显示 CDK5R1 ELISA试剂盒) cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration.

  5. Cdk5/p35 (显示 RPLP0 ELISA试剂盒) did not have major effects on tau toxicity or phosphorylation.

  6. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration.

Zebrafish Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These results suggest that the phosphorylation of Dpysl2 (显示 DPYSL2 ELISA试剂盒) and Dpysl3 (显示 DPYSL3 ELISA试剂盒) by Cdk5 and DYRK2 (显示 DYRK2 ELISA试剂盒) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.

  2. cdk5 mRNA was injected into the one- to two-cell embryos, in which neuron apoptosis was inhibited compared with the uninjected control embryos.

  3. we have cloned and characterized the zebrafish cdk5 ortholog. Zebrafish cdk5 is 96% identical to its human counterpart and expressed as early as the blastula stage.

  4. cdk5 plays a critical role in spinal and cranial motor neuron development.

CDK5 抗原简介

Antigen Summary

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin-dependent kinase 5 (CDK5) Elisa Kit
  • cyclin-dependent kinase 5 (Cdk5) Elisa Kit
  • Cyclin-dependent kinase 5 (Cdk5) Elisa Kit
  • cyclin-dependent kinase 5 (cdk5) Elisa Kit
  • cyclin-dependent kinase 5 (LOC100352775) Elisa Kit
  • cyclin-dependent protein kinase 5 (cdk5) Elisa Kit
  • AW048668 Elisa Kit
  • cdk5 Elisa Kit
  • CG8203 Elisa Kit
  • Crk6 Elisa Kit
  • DmCdk5 Elisa Kit
  • Dmel\\CG8203 Elisa Kit
  • PSSALRE Elisa Kit
  • zgc:101604 Elisa Kit

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , PDPK , proline-directed protein kinase 33 kDa subunit , CG8203-PA , Cdk5-PA , neuronal cyclin-dependent kinase 5

GENE ID SPECIES
1020 Homo sapiens
12568 Mus musculus
140908 Rattus norvegicus
281066 Bos taurus
100190948 Gallus gallus
475537 Canis lupus familiaris
733700 Sus scrofa
36727 Drosophila melanogaster
399296 Xenopus laevis
100732840 Cavia porcellus
100190973 Ovis aries
100352775 Oryctolagus cuniculus
65234 Danio rerio
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