BRCA1 (BRCA1) ELISA试剂盒产品概述

Full name:
Breast Cancer 1 ELISA试剂盒 (BRCA1)
在www.antibodies-online.cn可供33 Breast Cancer 1 (BRCA1) ELISA试剂盒的13不同的供货商。 再加上,我们可以发BRCA1 抗体 (583)BRCA1 蛋白 (10)和数多这个蛋白质的别的产品。 总共641 BRCA1产品已列进来了。
BRCA1, brcai, brcc1, BROVCA1, iris, LOC100224649, PNCA4, PPP1R53, pscp, rnf53

适于 BRCA1 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. both murine Brca1185stop tumors and human BRCA1185delAG breast cancer cells express a new gene domain-less (RING-less) BRCA1 protein that mediated resistance to homologous recombination deficient-targeted therapies

  2. Genomic instability can be rescued by deletion of Trp53bp1 (显示 TP53BP1 ELISA试剂盒), encoding the DNA damage response factor 53BP1 (显示 TP53BP1 ELISA试剂盒); mice expressing RING-less BRCA1 do not show an increased susceptibility to tumors in the absence of 53BP1 (显示 TP53BP1 ELISA试剂盒); Genomic instability in cells expressing RING-less BRCA1 correlates with loss of BARD1 (显示 BARD1 ELISA试剂盒) and a defect in restart of replication forks after hydroxyurea treatment

  3. the aberrant proliferative capacity of Brca1(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling.

  4. We report here elevated recombination rates at telomeres in cells from human BRCA1 mutation carriers and in mouse embryonic stem cells lacking both copies of functional Brca1.

  5. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 and a decline of stem cell function, which was rescued by p16 loss.

  6. Brca1-Wwox (显示 WWOX ELISA试剂盒) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (显示 WWOX ELISA试剂盒)-sufficient cells

  7. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  8. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  9. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (显示 COBRA1 ELISA试剂盒)-dependent transcription program during mammary gland development.

  10. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

Human Breast Cancer 1 (BRCA1) interaction partners

  1. both murine Brca1185stop tumors and human BRCA1185delAG breast cancer cells express a new gene domain-less (RING-less) BRCA1 protein that mediated resistance to homologous recombination deficient-targeted therapies

  2. RING-deficient BRCA1 proteins are hypomorphic and capable of contributing to PARPi and platinum resistance when expressed at high levels

  3. Founder mutations in BRCA1 contribute to an increased risk of ovarian cancer in the western Danish population.

  4. BRCA1 germline mutation is associated with triple-negative breast cancer.

  5. BRCA1 c.5434C>G and c.213-5T>A pathogenic mutations from Norwegian breast or ovarian cancer cohort do not have trans-activation ability.

  6. results from our detailed mRNA analysis suggest that BRCA-associated cancer risk is likely not markedly increased for individuals who carry a truncating variant in BRCA1 exons 9 or 10, or any other BRCA1 allele that permits 20-30% of tumor suppressor function.

  7. Findings establish L35P as the first pathogenic missense mutation in PALB2 and directly demonstrate the requirement of the PALB2-BRCA1 interaction for breast cancer suppression.

  8. These results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2.

  9. This study implicates novel risk loci as well as highlights the clinical utility for retesting BRCA1/2 negative ovarian cancer patients by genomic sequencing and analysis of genes in relevant pathways.

  10. Women with BRCA1/2 mutations show at diagnosis higher peritoneal tumor load and increased frequency of bulky lymph nodes compared to patients without germline BRCA mutations. Primary debulking surgery seems to ensure a longer progression-free survival in women with BRCA wild type genotype compared to neoadjuvant chemotherapy.

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 抗原简介

Antigen Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1, early onset (BRCA1) Elisa Kit
  • breast cancer 1, early onset (brca1) Elisa Kit
  • breast cancer 1, early onset (LOC100224649) Elisa Kit
  • breast cancer 1, early onset (LOC100347269) Elisa Kit
  • breast cancer 1 (Brca1) Elisa Kit
  • breast cancer 1, early onset (Brca1) Elisa Kit
  • BRCA1 Elisa Kit
  • brcai Elisa Kit
  • brcc1 Elisa Kit
  • BROVCA1 Elisa Kit
  • iris Elisa Kit
  • LOC100224649 Elisa Kit
  • PNCA4 Elisa Kit
  • PPP1R53 Elisa Kit
  • pscp Elisa Kit
  • rnf53 Elisa Kit

Protein level used designations for Breast Cancer 1 (BRCA1) ELISA试剂盒

BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , breast cancer type 1 susceptibility protein homolog , breast cancer 1, early onset , BRCA1 homolog , breast and ovarian cancer susceptibility protein , breast cancer associated 1

672 Homo sapiens
353120 Bos taurus
373983 Gallus gallus
403437 Canis lupus familiaris
449497 Pan troglodytes
554178 Monodelphis domestica
712634 Macaca mulatta
733513 Xenopus (Silurana) tropicalis
755086 Strongylocentrotus purpuratus
100049662 Sus scrofa
100051990 Equus caballus
100224649 Taeniopygia guttata
100347269 Oryctolagus cuniculus
12189 Mus musculus
497672 Rattus norvegicus
493761 Felis catus
399391 Xenopus laevis
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