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the aggregation of rpS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase.
Data suggest ribosomal protein S6 (rpS6) as tumor marker for renal cell carcinoma.
Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer
p-rpS6 is a robust post-treatment indicator of HER2 (显示 ERBB2 ELISA试剂盒) pathway-targeted therapy resistance
Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K (显示 RPS6KB1 ELISA试剂盒) and RPS6 activation.
Tanshinone IIA inhibits HIF-1alpha (显示 HIF1A ELISA试剂盒) and VEGF (显示 VEGFA ELISA试剂盒) expression in breast cancer cells via mTOR (显示 FRAP1 ELISA试剂盒)/p70S6K (显示 RPS6KB1 ELISA试剂盒)/RPS6/4E-BP1 (显示 EIF4EBP1 ELISA试剂盒) signaling pathway.
The expression levels of phospho-mTOR and phospho-S6RP may be potential predictive biomarkers for efficacy of everolimus in patients with metastatic renal cell carcinoma.
we report that phosphorylation of ribosomal protein S6 is greatly increased in BRCA1 deficient cells resistant to PARP (显示 COL11A2 ELISA试剂盒) inhibition
High Ribosomal Protein S6 is associated with renal cell carcinoma metastases.
a novel mechanism for modulating the RPS6 function by PP1 (显示 PPA1 ELISA试剂盒) and ATM (显示 ATM ELISA试剂盒) which regulates cell growth and survival in response to DNA-damage stim
in adult cardiac myocytes 4-hydroxy-trans-2-nonenal stimulates protein synthesis by activation of mTORC1-p70S6K (显示 RPS6KB1 ELISA试剂盒)-RPS6 signaling
rpS6 phosphorylation facilitates the increase in cyclin D1 (显示 CCND1 ELISA试剂盒) and decrease in cyclin E1 (显示 CCNE1 ELISA试剂盒) that underlie the hypertrophic nature of uninephrectomy-induced kidney growth.
The mTORC1 effectors, RPS6 and eIF4E, play distinct roles and are both necessary for AKT/Ras hepatocarcinogenesis.
Activation of mTORC2 (显示 CRTC2 ELISA试剂盒) plays a pivotal role in cardioprotection, and Rps6 is a convergence point of cardioprotective signaling, providing positive feedback regulation of mTORC2 (显示 CRTC2 ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒) signaling.
Data indicate that the mTOR (显示 FRAP1 ELISA试剂盒) activity evaluated by the phosphorylation status of ribosomal protein S6, and phospho-S6 (pS6) levels was found declined shortly after rapamycin treatment in both cortex and hippocampus.
Downregulation of HELZ (显示 HELZ ELISA试剂盒) reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6.
regulatory protein (显示 TGFB1 ELISA试剂盒) S6 phosphorylation is controlled by Akt (显示 AKT1 ELISA试剂盒), downstream to PI-3K and upstream to mTOR (显示 FRAP1 ELISA试剂盒) in an IL2 (显示 IL2 ELISA试剂盒)-mediated signal transduction pathway
Rps6 phosphorylation is a determinant of cell size and glucose homeostasis.
the phosphorylation of Tyr (显示 TYR ELISA试剂盒)(1077) on LepRb (显示 LEPR ELISA试剂盒) during receptor activation, substantiate the hypothalamic regulation of STAT5 (显示 STAT5A ELISA试剂盒) and S6 by leptin (显示 LEP ELISA试剂盒), and define the alternate LepRb (显示 LEPR ELISA试剂盒) signaling pathways
rpS6, especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis
molecular network including eIF1AX (显示 EIF1AY ELISA试剂盒), RPS7 (显示 RPS7 ELISA试剂盒), and 14-3-3gamma (显示 YWHAG ELISA试剂盒) regulates protein translation and cell proliferation in BMECs.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR (显示 FRAP1 ELISA试剂盒)-RPS6K-RPS6-EIF4EBP1 (显示 EIF4EBP1 ELISA试剂盒) signal transduction pathway.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
40S ribosomal protein S6
, phosphoprotein NP33
, ribosomal Protein, Small subunit (28.1 kD) (rps-6)
, ribosomal protein S6 a
, hemocytes enlarged
, lethal(1)aberrant immune response
, lethal-(1)-haemocytes enlarged
, minute (1) 7BC
, ribosomal protein S6