anti-Perforin 1 (PRF1) 抗体产品概述

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anti-Perforin 1 (Pore Forming Protein) 抗体 (PRF1)
在www.antibodies-online.cn可供198 Perforin 1 (Pore Forming Protein) (PRF1) 抗体的23不同的供货商。 再加上,我们可以发Perforin 1 试剂盒 (84)Perforin 1 蛋白 (12)和数多这个蛋白质的别的产品。 总共303 Perforin 1产品已列进来了。
别名:
Cyta, FLH2, HPLH2, LOC443187, P1, perforin, Pfn, PFN1, Pfp, Prf-1, prf1, RATCYTA

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  1. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2657991 : Lieberman: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. in Nature reviews. Immunology 2003 (PubMed)
    Show all 11 references for 2657991

  2. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2657572 : Trapani, Smyth: Functional significance of the perforin/granzyme cell death pathway. in Nature reviews. Immunology 2002 (PubMed)
    Show all 11 references for 2657572

  3. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2662106 : Hameed, Olsen, Cheng, Fox, Hruban, Podack: Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody. in The American journal of pathology 1992 (PubMed)
    Show all 10 references for 2662106

  4. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2658819 : Barrat, Le Deist, Benkerrou, Bousso, Feldmann, Fischer, de Saint Basile: Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
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  5. Mouse (Murine) Monoclonal Perforin 1 Primary Antibody for ICC, IF - ABIN4344818 : Crider-Pirkle, Billingsley, Faust, Hardy, Lee, Weitlauf: Cubilin, a binding partner for galectin-3 in the murine utero-placental complex. in The Journal of biological chemistry 2002 (PubMed)
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  6. Human Monoclonal Perforin 1 Primary Antibody for IHC (fro), FACS - ABIN610399 : Chang, Xing, Pan, Algeciras-Schimnich, Barnhart, Yaish-Ohad, Peter, Yang: c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. in The EMBO journal 2002 (PubMed)
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  7. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN1108624 : Payne, Kløverpris, Sacha, Brumme, Brumme, Buus, Sims, Hickling, Riddell, Chen, Luzzi, Edwards, Phillips, Prado, Goulder: Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells. in Journal of virology 2010 (PubMed)
    Show all 2 references for 1108624

  8. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN1108622 : Cellerai, Perreau, Rozot, Bellutti Enders, Pantaleo, Harari: Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression. in Journal of virology 2010 (PubMed)

  9. Cow (Bovine) Polyclonal Perforin 1 Primary Antibody for WB - ABIN2775294 : Okur, Balta, Akarsu, Oner, Patiroglu, Bay, Sayli, Unal, Gurgey: Clinical and molecular aspects of Turkish familial hemophagocytic lymphohistiocytosis patients with perforin mutations. in Leukemia research 2008 (PubMed)

更多抗Perforin 1的相互作用对抗体

Human Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

  1. A girl with neurological manifestations of familial hemophagocytic lymphohistiocytosis 2 had reduced perforin 1 expression and was found to be homozygous for a mutation in PRF1 at codon 637 in exon 3 (c.673C>T p.Arg225Trp). Her non-consanguineous parents were both heterozygous carriers of this mutation.

  2. Mutation in PRF1 gene is associated with hemophagocytic lymphohistiocytosis.

  3. Increased TIM3 (显示 HAVCR2 抗体)+CD8 (显示 CD8A 抗体)+T cells with lower perforin and granzyme B (显示 Gzmb 抗体) expression and higher CD95 (显示 FAS 抗体) expression in MDS (显示 PAFAH1B1 抗体) patients were observed.

  4. ITP (显示 ITPA 抗体) patients displayed an increased frequency of rare missense variations of the PRF1 gene

  5. The decreased expression of perforin in circulating CD3 (显示 CD3 抗体)+CD8 (显示 CD8A 抗体)+ positive T cells is an important biomarker of damaged antitumor immunity in advanced lung cancer.

  6. Letter/Case Report: recurrent episodes of macrophage activation syndrome in peripheral spondyloarthritis with monoallelic missense mutations in PRF1.

  7. PRF delivers granulysin (显示 GNLY 抗体) and granzymes into parasite infected cells to kill the parasite.

  8. Among SLAMF4 (显示 CD244 抗体)+ cells, the T cell fraction positive for perforin and granzyme B (显示 Gzmb 抗体) was higher in those obtained from healthy donors compared to SLE patients.

  9. monoallelic mutations of PRF1 decrease NK-cell cytotoxicity should be considered in individuals presenting with the manifestations of immune deficiency states that impinge on NK-cell cytotoxicity.

  10. Calcific aortic valve disease is characterized by increased expression of granzymes and perforin.

Mouse (Murine) Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

  1. Furthermore, perforin production specifically by CD8 (显示 CD8A 抗体) T cells was required to cause fatal edema during experimental cerebral malaria.

  2. Our study suggests that perforin plays a role in dopaminergic neuron loss in PD.

  3. IL-18 (显示 IL18 抗体)-elicited NK cell perforin responses seem to be critical for coordinating mucosal inflammation during early infection

  4. study shows that perforin is essential to facilitate beta cell destruction in mouse models of type 1 diabetes

  5. Released granzyme B (显示 Gzmb 抗体) induces DNA fragmentation in intraepithelial lymphocytes independently of Perforin

  6. serglycin (显示 SRGN 抗体) plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin and granzyme B (显示 Gzmb 抗体), whereas granzyme A (显示 GZMA 抗体) is unaffected

  7. This suggests that LPS alters UNK cell migration and activates cytotoxic granule release.

  8. it is proposed that Ca(2 (显示 CA2 抗体)+) binding at the weakest affinity site triggers changes in the perforin C2 domain that facilitate its interaction with lipid membranes

  9. a lack of perforin and absence of the specific activation of NK cells during acute MCMV infection lead to an unleashed CD8 (显示 CD8A 抗体)(+) T cell response that is detrimental for the host.

  10. CD8 (显示 CD8A 抗体) T cells are sufficient as a sole perforin-expressing cell type to cause BBB (显示 ALMS1 抗体) disruption in the PIFS (显示 PROC 抗体) model.

Cow (Bovine) Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

  1. It is a cytotoxic genes in the endometrium and hightly expressed in the peri (显示 PLIN1 抗体)-implantation endometrium.

Perforin 1 (PRF1) 抗原简介

Antigen Summary

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with Perforin 1 (PRF1)

  • perforin 1 (pore forming protein) (PRF1) 抗体
  • perforin (LOC443187) 抗体
  • perforin (prf1) 抗体
  • perforin 1 (pore forming protein) (Prf1) 抗体
  • perforin 1-like (LOC100342396) 抗体
  • Cyta 抗体
  • FLH2 抗体
  • HPLH2 抗体
  • LOC443187 抗体
  • P1 抗体
  • perforin 抗体
  • Pfn 抗体
  • PFN1 抗体
  • Pfp 抗体
  • Prf-1 抗体
  • prf1 抗体
  • RATCYTA 抗体

Protein level used designations for PRF1

perforin 1 (pore forming protein) , perforin-1-like , perforin , perforin-1 , cytolysin , lymphocyte pore forming protein , lymphocyte pore-forming protein , P1 , pore forming protein

GENE ID SPECIES
450512 Pan troglodytes
100404817 Callithrix jacchus
100473675 Ailuropoda melanoleuca
443187 Ovis aries
100113473 Felis catus
100136143 Oncorhynchus mykiss
5551 Homo sapiens
18646 Mus musculus
50669 Rattus norvegicus
369025 Bos taurus
489030 Canis lupus familiaris
396595 Sus scrofa
100730283 Cavia porcellus
100342396 Oryctolagus cuniculus
427784 Gallus gallus
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