Use your antibodies-online credentials, if available.
Select your species
Describe an autoinhibitory mechanism for ITCH ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Data show that the E3 ubiquitin ligase Itch forms a complex with tricellulin (显示 MARVELD2 ELISA试剂盒) and thereby enhances its ubiquitination.
ASPP2 (显示 TP53BP2 ELISA试剂盒) suppresses invasion, peritoneal dissemination and TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced EMT (显示 ITK ELISA试剂盒) by inhibiting Smad7 (显示 SMAD7 ELISA试剂盒) degradation mediated by ITCH in gastric cancer cells.
WBP2 (显示 WBP2 ELISA试剂盒)/ITCH signaling functions to link the intricate Wnt (显示 WNT2 ELISA试剂盒) and Hippo signaling networks in breast cancer.
The cellular ubiquitin ligase, Itch, is required for Kaposi's sarcoma herpesvirus RTA (显示 RBM9 ELISA试剂盒) induced degradation of vFLIP.
Results indicate that TAX1BP1 (显示 TAX1BP1 ELISA试剂盒) functions as an adaptor molecule for Itch to target MAVS (显示 MAVS ELISA试剂盒) during RNA virus infection and thus restrict virus-induced apoptosis.
These data demonstrate that Itch, ubiquitin, and Alix (显示 PDCD6IP ELISA试剂盒) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.
The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain of the host E3 ubiquitin ligase ITCH.
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
cir (显示 KCNJ5 ELISA试剂盒)-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression
this study identified a previously unknown role for Itch in regulating IL-17 (显示 IL17A ELISA试剂盒)-mediated colonic inflammation and carcinogenesis
Itch monoubiquitinates SMN (显示 STMN1 ELISA试剂盒) and monoubiquitination of SMN (显示 STMN1 ELISA试剂盒) plays an important role in regulating its cellular localization.
ITCH targets TXNIP (显示 TXNIP ELISA试剂盒) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (显示 TXN ELISA试剂盒) system.
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
Impaired ITCH results in heightened TNF (显示 TNF ELISA试剂盒) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (显示 TNF ELISA试剂盒) signaling is genetically deleted.
ITCH modulates SIRT6 (显示 SIRT6 ELISA试剂盒) and SREBP2 (显示 SREBF2 ELISA试剂盒) to influence lipid metabolism and atherosclerosis in ApoE (显示 APOE ELISA试剂盒) null mice
In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.
The E3 ubiquitin ligase Itch inhibits p38alpha (显示 MAPK14 ELISA试剂盒) signaling and skin inflammation through the ubiquitylation of Tab1 (显示 TAB1 ELISA试剂盒).
Ndfip1 (显示 NDFIP1 ELISA试剂盒) regulates itch ligase activity and airway inflammation via UbcH7 (显示 UBE2L3 ELISA试剂盒).
The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (显示 FOXP3 ELISA试剂盒) expression independently of Itch.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase Itchy homolog
, NFE2-associated polypeptide 1
, atrophin-1 interacting protein 4
, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
, itchy E3 ubiquitin protein ligase homolog
, E3 ubiquitin-protein ligase Itchy