alpha Ketoglutarate Dehydrogenase 蛋白 (alphaKGDHC)

alphaKGDHC encodes one subunit of the 2-oxoglutarate dehydrogenase complex. 再加上,我们可以发alpha Ketoglutarate Dehydrogenase 抗体 (54)alpha Ketoglutarate Dehydrogenase 试剂盒 (31)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
alphaKGDHC 4967 Q02218
alphaKGDHC 18293 Q60597
大鼠 alphaKGDHC alphaKGDHC 360975 Q5XI78

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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 88至92个工作日
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 88至92个工作日
¥278,287.59
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HOST_HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 28至34个工作日
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大肠杆菌(E. Coli) His tag Validation with Western Blot 50 μg Log in to see 28至34个工作日
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酵母菌 Mesocricetus auratus His tag   1 mg Log in to see 24至35个工作日
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大肠杆菌(E. Coli) T7 tag,His tag   100 μg Log in to see 9至12个工作日
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alphaKGDHC 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

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Human alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS (显示 LIAS 蛋白)), which when mutated stabilize HIF1alpha (显示 HIF1A 蛋白) in a non-hydroxylated form.

  2. Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types

  3. Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium.

  4. 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah

  5. Reduction in the E2k (显示 DLST 蛋白) subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Mouse (Murine) alpha Ketoglutarate Dehydrogenase (alphaKGDHC) interaction partners

  1. The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.

  2. Alpha-ketoglutarate dehydrogenase is a primary site of ROS (显示 ROS1 蛋白) production in normally functioning mitochondria.

  3. In the postnatal mouse brain,high mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons.

蛋白简介alpha Ketoglutarate Dehydrogenase (alphaKGDHC)

蛋白简介

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with alphaKGDHC

  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH)
  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (Ogdh)
  • 2210403E04Rik 蛋白
  • 2210412K19Rik 蛋白
  • AA409584 蛋白
  • AKGDH 蛋白
  • d1401 蛋白
  • E1k 蛋白
  • mKIAA4192 蛋白
  • OGDC 蛋白

Protein level used designations for alphaKGDHC

2-oxoglutarate dehydrogenase, mitochondrial , 2-oxoglutarate dehydrogenase complex component E1 , OGDC-E1 , oxoglutarate decarboxylase , oxoglutarate dehydrogenase (succinyl-transferring) , 2-oxoglutarate dehydrogenase E1 component, mitochondrial , alpha-ketoglutarate dehydrogenase , oxoglutarate dehydrogenase (lipoamide)

GENE ID SPECIES
426429 Gallus gallus
4967 Homo sapiens
475499 Canis lupus familiaris
534599 Bos taurus
18293 Mus musculus
360975 Rattus norvegicus
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