TIMP Metallopeptidase Inhibitor 1 蛋白 (TIMP1)

TIMP1 belongs to the TIMP gene family. 再加上,我们可以发TIMP1 抗体 (309)TIMP1 试剂盒 (143)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
TIMP1 7076 P01033
TIMP1 116510 P30120
TIMP1 21857 P12032
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Showing 10 out of 58 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells 小鼠 非结合性 10 μg Log in to see 10至12个工作日
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
人细胞 His tag 10 μg Log in to see 20至21个工作日
HEK-293 Cells 非结合性   10 μg Log in to see 10至12个工作日
人细胞 小鼠 非结合性 10 μg Log in to see 20至21个工作日
人细胞 大鼠 非结合性 10 μg Log in to see 20至21个工作日
HEK-293 Cells His tag 10 μg Log in to see 2至3个工作日
大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
大肠杆菌(E. Coli) MBP tag 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg Log in to see 6至9个工作日

TIMP1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , , , ,
, , ,
Rat (Rattus) ,

Mouse (Murine) , , ,

更多TIMP Metallopeptidase Inhibitor 1 (TIMP1)互动伙伴

Human TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. these results show here that EGFR signaling induces TIMP-1 expression in colorectal cancer cells, and that TIMP-1 promotes a more aggressive behavior, specifically in KRAS mutated cells

  2. Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes.

  3. The plasma levels of interleukin (IL)-1beta (显示 IL1B 蛋白), tumor necrosis factor (TNF)-alpha (显示 TNF 蛋白), tissue inhibitor of metalloproteinases (TIMP)-1 are increased in myelofibrosis (MF) patients.

  4. The present study suggests that scoring of TIMP-1 immunoreactivity is a better choice than measuring of TIMP-1 plasma levels.

  5. Results show that TIMP1 expression is significantly upregulated in human colon cancer. Its suppression decreases proliferation, and metastasis but increases apoptosis by inducing TIMP1 specific regulated FAK (显示 PTK2 蛋白)-PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) and MAPK (显示 MAPK1 蛋白) pathway. These results suggest that TIMP1 may play an important role in promoting tumorigenesis and metastasis of human colon cancer.

  6. cancer associated fibroblasts (CAFs) promoted hepatocellular cancer (HCC) growth via IL-6/STAT3/AKT pathway and TIMP-1 over-expression driven by IL-6/STAT3 pathway in HCC cells brought in more CAFs through activating liver fibroblasts.

  7. Tissue inhibitor of matrix metalloproteinases 1 (TIMP1) inhibition resensitized tumors to gemcitabine and radiotherapy.

  8. Suggest that IL-6 (显示 IL6 蛋白) could promote the invasiveness of breast cancer cells by inducing secretion of TIMP-1 and -2, causing a disturbance in TIMP/MMP balance.

  9. This study indicates that in our population, the COL4A3 (显示 COL4a3 蛋白) rs55703767 polymorphism decreased the risk of KC. However, the TIMP-1 rs6609533 polymorphism was associated with an increased risk of KC.

  10. Low MMP-8 (显示 MMP8 蛋白)/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome

Cow (Bovine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. Decreased MMP-9 (显示 MMP9 蛋白) and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.

  2. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF (显示 EGF 蛋白) on MMP-9 (显示 MMP9 蛋白) and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.

  3. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha (显示 TNF 蛋白), and hepatocyte growth factor (显示 HGF 蛋白) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 (显示 TIMP2 蛋白) mRNA was not affected by any treatments.

  4. the different temporal expression patterns of TIMP-1 and TIMP-2 (显示 TIMP2 蛋白) suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 (显示 TIMP2 蛋白) may play significant roles during luteal development and maintenance

  5. analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor

Pig (Porcine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. Results provide evidence for the utility of MMP9 (显示 MMP9 蛋白) and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.

  2. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (显示 MMP9 蛋白), TIMP1, and NGAL (显示 LCN2 蛋白) (also MMP2 (显示 MMP2 蛋白) in 220 kDa complex) without proteolytic activity.

  3. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (显示 VEGFA 蛋白), pro-MMP-9 (显示 MMP9 蛋白), MMP-2 (显示 MMP2 蛋白), VEGFR-1 (显示 FLT1 蛋白), VEGFR-2 (显示 KDR 蛋白), and TIMP-1, which may contribute to the development of venous stenosis.

  4. Results indicate that leukemia inhibitory factor (LIF (显示 LIF 蛋白)) and Oncostatin M (显示 OSM 蛋白) increase the expression of MMP-1 (显示 MMP1 蛋白), MMP-3 (显示 MMP3 蛋白), and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF (显示 LIF 蛋白) antagonist MH35-BD.

Rabbit TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2 (显示 MMP2 蛋白), MMP-9 (显示 MMP9 蛋白) and TIMP-1 in rabbits with acute paraquat poisoning.

Mouse (Murine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. These results show that MMP-9 (显示 MMP9 蛋白)/TIMP-1 system disturbance and changes of histological structure in uteri tissue are involved in fluoride-induced reproductive dysfunctions.

  2. Tissue inhibitor of matrix metalloproteinases 1 (TIMP1) inhibition resensitized tumors to gemcitabine and radiotherapy.

  3. proteomic analysis of the mesenchymal stem cells secretome identified the TIMP-1 as a potential effector molecule responsible for the anti-angiogenic properties of MSC (显示 MSC 蛋白)

  4. TIMP1 signaling via CD63 (显示 CD63 蛋白) leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.

  5. This study highlights a previously undescribed integral role for TIMP1 in both vascular network maturation and adaptations to ischemia or alterations in flow.

  6. TIMP-1 was identified as a selectively upregulated component secreted from immature astrocytes from human pluripotent stem cells.

  7. demonstrate that TIMP-2 (显示 TIMP2 蛋白) plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis

  8. Our findings reveal that elevated levels of TIMP-1 impact on neutrophil homeostasis via signaling through CD63 (显示 CD63 蛋白).

  9. TIMP-1 is a ligand of LRP-1 (显示 LRP1 蛋白) and we highlight a new example of its MMP-independent, cytokine-like functions.

  10. RAB37 (显示 RAB37 蛋白) regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 (显示 MMP9 蛋白) migration axis in vitro and in vivo and to suppress tumor metastasis.



This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Gene names and symbols associated with TIMP1

  • TIMP metallopeptidase inhibitor 1 (TIMP1)
  • TIMP metallopeptidase inhibitor 1 (Timp1)
  • tissue inhibitor of metalloproteinase 1 (Timp1)
  • Clgi 蛋白
  • DKFZp468A0912 蛋白
  • EPA 蛋白
  • EPO 蛋白
  • HCI 蛋白
  • Timp 蛋白
  • TIMP-1 蛋白
  • TIMP1 蛋白

Protein level used designations for TIMP1

tissue inhibitor of matrix metalloproteinase-1 , TIMP metallopeptidase inhibitor 1 , Metalloproteinase inhibitor 1 , TIMP-1 , collagenase inhibitor , erythroid potentiating activity , erythroid-potentiating activity , fibroblast collagenase inhibitor , metalloproteinase inhibitor 1 , tissue inhibitor of metalloproteinases 1 , EG-1 , embryogenin-1 , tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) , tissue inhibitor of metallopeptidase 1 , tissue inhibitor of metalloproteinase 1 , metalloproteinase tissue inhibitor , metalloproteinase tissue inhibitor 1 , EPA , TPA-S1 , TPA-induced protein , collagenase inhibitor 16C8 fibroblast , tissue inhibitor of metalloproteinase-1

574348 Macaca mulatta
100172253 Pongo abelii
7076 Homo sapiens
282092 Bos taurus
116510 Rattus norvegicus
101686851 Mustela putorius furo
443331 Ovis aries
396862 Sus scrofa
403816 Canis lupus familiaris
100009047 Oryctolagus cuniculus
21857 Mus musculus
100034220 Equus caballus
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