TIMP Metallopeptidase Inhibitor 1 蛋白 (TIMP1)

TIMP1 belongs to the TIMP gene family. 再加上,我们可以发TIMP1 抗体 (306)TIMP1 试剂盒 (139)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
TIMP1 7076 P01033
TIMP1 116510 P30120
TIMP1 21857 P12032

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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
人细胞 His tag 10 μg Log in to see 14至15个工作日
¥2,036.83
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HOST_HEK-293 小鼠 非结合性 10 μg Log in to see 28至34个工作日
¥1,687.00
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人细胞 小鼠 非结合性 10 μg Log in to see 14至15个工作日
¥2,680.04
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人细胞 大鼠 非结合性 10 μg Log in to see 14至15个工作日
¥2,680.04
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
¥136,777.64
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HOST_HEK-293 Cells His tag 10 μg Log in to see 24至29个工作日
¥3,133.62
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
¥136,777.64
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HOST_HEK-293 非结合性   10 μg Log in to see 28至34个工作日
¥1,687.00
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HOST_Human 非结合性 10 μg Log in to see 24至29个工作日
¥3,351.20
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大肠杆菌(E. Coli) MBP tag 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg Log in to see 24至31个工作日
¥3,430.44
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TIMP1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , , , , , ,
, , ,
Rat (Rattus) ,

Mouse (Murine) , , , ,
,

引用最多的TIMP1 蛋白

  1. Human TIMP1 Protein expressed in Human Cells - ABIN2003615 : Osthues, Knäuper, Oberhoff, Reinke, Tschesche: Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. in FEBS letters 1992 (PubMed)
    Show all 4 references for 2003615

  2. Human TIMP1 Protein expressed in HEK-293 - ABIN2666716 : Kim, Kim, Kang, Ko: Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression. in BMB reports 2012 (PubMed)
    Show all 4 references for 2666716

  3. Rat (Rattus) TIMP1 Protein expressed in Human Cells - ABIN2009111 : Aljada, Ramnath, Donohue, Harvey, Brooks, Wiseman, Khoury, Loewen, Slocum, Anderson, Bepler, Tan: Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004 (PubMed)
    Show all 4 references for 2009111

  4. Mouse (Murine) TIMP1 Protein expressed in Human Cells - ABIN2007691 : Hornebeck: Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. in Pathologie-biologie 2003 (PubMed)
    Show all 4 references for 2007691

  5. Mouse (Murine) TIMP1 Protein expressed in HEK-293 - ABIN2666718 : Brew, Nagase: The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. in Biochimica et biophysica acta 2010 (PubMed)
    Show all 4 references for 2666718

更多TIMP Metallopeptidase Inhibitor 1 (TIMP1)互动伙伴

Human TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. This study indicates that in our population, the COL4A3 (显示 COL4a3 蛋白) rs55703767 polymorphism decreased the risk of KC. However, the TIMP-1 rs6609533 polymorphism was associated with an increased risk of KC.

  2. Low MMP-8 (显示 MMP8 蛋白)/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome

  3. Data show that the mean values for TIMP1, TIMP2 (显示 TIMP2 蛋白) and MMP2 (显示 MMP2 蛋白) were lower in survivors, MMP9 (显示 MMP9 蛋白) was higher in survivors.

  4. We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7 (显示 MMP7 蛋白), MMP-10 (显示 MMP10 蛋白) and TIMP-1 correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the diseaseMMP-10, MMP-7 (显示 MMP7 蛋白), TIMP-1, TIMP-2 (显示 TIMP2 蛋白) were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively.

  5. plasma concentrations of MMP-7 (显示 MMP7 蛋白), MMP-8 (显示 MMP8 蛋白), -9 and TIMP-1 within 96 h from the onset of acute pancreatitis symptoms are elevated in acute pancreatitis patients compared with healthy controls

  6. High TIMP1 expression is associated with hepatic fibrosis.

  7. TIMP-1 was highly expressed in TNBC patients and was associated with a poor prognosis.

  8. Results suggest a crucial role of MMP9 (显示 MMP9 蛋白) at the early stage of carcinogenesis in the large intestine. The increase in MMP9 (显示 MMP9 蛋白) and TIMP1 mRNA concentration and the decrease in MMP28 (显示 MMP28 蛋白) in the large intestinal tissue may be a confirmation of cancer.

  9. Expression of TIMP1 is i (显示 CD63 蛋白)ncreased in chronic pancreatitis, pancreatic intra-epithelial neoplasia, and pancreatic ductal adenocarcinoma tissues from patients. TIMP1 signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.

  10. Our study provides information on the dynamic changes of MMP-9 (显示 MMP9 蛋白)-TIMP-1 system and S100B (显示 S100B 蛋白) in the perioperative period. Preoperative reduction of TIMP-1 might be predictive for shunt requirement but future studies are required for verification.

Cow (Bovine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. Decreased MMP-9 (显示 MMP9 蛋白) and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.

  2. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF (显示 EGF 蛋白) on MMP-9 (显示 MMP9 蛋白) and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.

  3. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha (显示 TNF 蛋白), and hepatocyte growth factor (显示 HGF 蛋白) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 (显示 TIMP2 蛋白) mRNA was not affected by any treatments.

  4. the different temporal expression patterns of TIMP-1 and TIMP-2 (显示 TIMP2 蛋白) suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 (显示 TIMP2 蛋白) may play significant roles during luteal development and maintenance

  5. analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor

Pig (Porcine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (显示 MMP9 蛋白), TIMP1, and NGAL (显示 LCN2 蛋白) (also MMP2 (显示 MMP2 蛋白) in 220 kDa complex) without proteolytic activity.

  2. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (显示 VEGFA 蛋白), pro-MMP-9 (显示 MMP9 蛋白), MMP-2 (显示 MMP2 蛋白), VEGFR-1 (显示 FLT1 蛋白), VEGFR-2 (显示 KDR 蛋白), and TIMP-1, which may contribute to the development of venous stenosis.

  3. Results indicate that leukemia inhibitory factor (LIF (显示 LIF 蛋白)) and Oncostatin M (显示 OSM 蛋白) increase the expression of MMP-1 (显示 MMP1 蛋白), MMP-3 (显示 MMP3 蛋白), and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF (显示 LIF 蛋白) antagonist MH35-BD.

Rabbit TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2 (显示 MMP2 蛋白), MMP-9 (显示 MMP9 蛋白) and TIMP-1 in rabbits with acute paraquat poisoning.

Mouse (Murine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) interaction partners

  1. proteomic analysis of the mesenchymal stem cells secretome identified the TIMP-1 as a potential effector molecule responsible for the anti-angiogenic properties of MSC (显示 MSC 蛋白)

  2. TIMP1 signaling via CD63 (显示 CD63 蛋白) leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.

  3. This study highlights a previously undescribed integral role for TIMP1 in both vascular network maturation and adaptations to ischemia or alterations in flow.

  4. TIMP-1 was identified as a selectively upregulated component secreted from immature astrocytes from human pluripotent stem cells.

  5. demonstrate that TIMP-2 (显示 TIMP2 蛋白) plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis

  6. Our findings reveal that elevated levels of TIMP-1 impact on neutrophil homeostasis via signaling through CD63 (显示 CD63 蛋白).

  7. TIMP-1 is a ligand of LRP-1 (显示 LRP1 蛋白) and we highlight a new example of its MMP-independent, cytokine-like functions.

  8. RAB37 (显示 RAB37 蛋白) regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 (显示 MMP9 蛋白) migration axis in vitro and in vivo and to suppress tumor metastasis.

  9. PDGF-D (显示 PDGFD 蛋白) intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2 (显示 MMP2 蛋白)/MMP (显示 MMP2 蛋白)-9 (显示 MMP9 蛋白) system, and PDGF-D (显示 PDGFD 蛋白) signaling is mediated through both PDGF (显示 PDGFA 蛋白)-alpha and -beta receptors.

  10. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (显示 MAPK14 蛋白) signaling pathway.

蛋白简介TIMP1

蛋白简介

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Gene names and symbols associated with TIMP1

  • TIMP metallopeptidase inhibitor 1 (TIMP1)
  • TIMP metallopeptidase inhibitor 1 (Timp1)
  • tissue inhibitor of metalloproteinase 1 (LOC100009047)
  • tissue inhibitor of metalloproteinase 1 (Timp1)
  • Clgi 蛋白
  • DKFZp468A0912 蛋白
  • EPA 蛋白
  • EPO 蛋白
  • HCI 蛋白
  • Timp 蛋白
  • TIMP-1 蛋白
  • TIMP1 蛋白

Protein level used designations for TIMP1

tissue inhibitor of matrix metalloproteinase-1 , TIMP metallopeptidase inhibitor 1 , Metalloproteinase inhibitor 1 , TIMP-1 , collagenase inhibitor , erythroid potentiating activity , erythroid-potentiating activity , fibroblast collagenase inhibitor , metalloproteinase inhibitor 1 , tissue inhibitor of metalloproteinases 1 , EG-1 , embryogenin-1 , tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) , tissue inhibitor of metallopeptidase 1 , tissue inhibitor of metalloproteinase 1 , metalloproteinase tissue inhibitor , metalloproteinase tissue inhibitor 1 , EPA , TPA-S1 , TPA-induced protein , collagenase inhibitor 16C8 fibroblast , tissue inhibitor of metalloproteinase-1

GENE ID SPECIES
574348 Macaca mulatta
100172253 Pongo abelii
7076 Homo sapiens
282092 Bos taurus
116510 Rattus norvegicus
101686851 Mustela putorius furo
443331 Ovis aries
396862 Sus scrofa
403816 Canis lupus familiaris
100009047 Oryctolagus cuniculus
21857 Mus musculus
100034220 Equus caballus
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