Poly A Specific Ribonuclease (PARN) ELISA试剂盒

The protein encoded by PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. 再加上,我们可以发PARN 抗体 (66)PARN 蛋白 (15)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
PARN 5073 O95453
大鼠 PARN PARN 360464  
PARN 74108 Q8VDG3

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0.27 ng/mL 0.78-50 ng/mL 96 Tests Log in to see 7至10个工作日
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Human Poly A Specific Ribonuclease (PARN) interaction partners

  1. PARN is a new component of the ribosome biogenesis machinery in human cells.

  2. provide evidence that PARN can also deadenylate the U6 and RMRP (显示 NME1 ELISA试剂盒) RNAs without affecting their levels

  3. poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S pre-rRNA maturation in human cells

  4. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (显示 PABPN1 ELISA试剂盒) and the poly(A)-specific RNase PARN.

  5. PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10.

  6. Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination.

  7. results highlight the clinical significance of PARN and NOC on the survival in SCC (显示 CYP11A1 ELISA试剂盒) diagnosed patients.

  8. Mutations in the PARN gene cause dyskeratosis congenital.

  9. The results indicate that the cellular level of miR (显示 MLXIP ELISA试剂盒)-122 is determined by the balance between the opposing effects of GLD-2 (显示 PAPD4 ELISA试剂盒) and PARN/CUGBP1 (显示 CELF1 ELISA试剂盒) on the metabolism of its 3'-terminus.

  10. 3 families with dyskeratosis congenita had key domain mutations in PARN shortening telomeres, reducing deadenylation, and downregulating TERC, DKC1 (显示 DKC1 ELISA试剂盒), RTEL1 (显示 RTEL1 ELISA试剂盒), and TERF1 (显示 TERF1 ELISA试剂盒).

Mouse (Murine) Poly A Specific Ribonuclease (PARN) interaction partners

  1. these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement.

  2. poly(A) polymerase (显示 PAPOLA ELISA试剂盒) Gld2 (显示 PAPD4 ELISA试剂盒), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (显示 NGDN ELISA试剂盒)) are components of a dendritic CPEB (显示 CPEB1 ELISA试剂盒)-associated polyadenylation apparatus

  3. Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode.

  4. A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site.

PARN 抗原简介

Antigen Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PARN

  • poly(A)-specific ribonuclease (parn) 抗体
  • poly(A)-specific ribonuclease (PARN) 抗体
  • poly(A)-specific ribonuclease (Parn) 抗体
  • poly(A)-specific ribonuclease (deadenylation nuclease) (parn) 抗体
  • poly(A)-specific ribonuclease (deadenylation nuclease) (Parn) 抗体
  • 1200003I18Rik 抗体
  • DAN 抗体
  • parn-A 抗体
  • RGD1565449 抗体
  • xparn 抗体
  • zgc:56067 抗体

Protein level used designations for PARN

deadenylating nuclease , deadenylation nuclease , poly(A)-specific ribonuclease (deadenylation nuclease) , poly(A)-specific ribonuclease PARN , polyadenylate-specific ribonuclease

GENE ID SPECIES
394409 Xenopus laevis
5073 Homo sapiens
479839 Canis lupus familiaris
524155 Bos taurus
360464 Rattus norvegicus
100172259 Pongo abelii
791461 Danio rerio
74108 Mus musculus
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