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The protein encoded by PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. 再加上，我们可以发PHF8 抗体 (33) 和 PHF8 蛋白 (4)和数多这个蛋白质的别的产品。
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knockdown of pmaip1 (显示 PMAIP1 ELISA试剂盒) mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice.
The gene knockdown of PHF8 in (显示 MBD2 ELISA试剂盒) mouse embryonic carcinoma P1 (显示 RARA ELISA试剂盒)9 cells impairs RA-induced neuronal differentiatio (显示 DLG3 ELISA试剂盒)n.
an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate
Knockdown or knockout of PHF8 by RNAi or CRISPR-Cas9 system reduced the activation of HIF1alpha (显示 HIF1A ELISA试剂盒).
USP7 (显示 USP7 ELISA试剂盒) promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 (显示 CCNA2 ELISA试剂盒). and the interaction between USP7 (显示 USP7 ELISA试剂盒) and PHF8 is augmented during DNA damage.
PHF8 reduces the H3K9me2 level at the E2F4 (显示 E2F4 ELISA试剂盒) transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 (显示 E2F4 ELISA试剂盒) gene regulation
PHF2 (显示 PHF1 ELISA试剂盒) is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1 (显示 SUV39H1 ELISA试剂盒).
PHF8 promotes lung cancer cell growth and survival by regulating miR (显示 MLXIP ELISA试剂盒)-21.
knockdown of PHF8 led to a reduction in the number of migratory and invasive cells. Furthermore, downregulation of PHF8 attenuated the tumorigenicity of ESCC cells in vivo.
PHF8 is regulated by APC (显示 APC ELISA试剂盒)(cdc20 (显示 CDC20 ELISA试剂盒)) and plays an important role in the G2/M transition.
study identified the histone demethylase (显示 MBD2 ELISA试剂盒) PHF8 as a coactivator that is specifically recruited by RAR-alpha (显示 RARA ELISA试剂盒) fusions to activate expression of their downstream targets upon all-trans retinoic acid treatment in acute promyelocytic leukemia (显示 PML ELISA试剂盒)
Results show that PHF8 controls the expression of genes involved in cell adhesion and cytoskeleton organization such as RhoA (显示 RHOA ELISA试剂盒), Rac1 and GSK3beta (显示 GSK3b ELISA试剂盒).
a role of PHF8 in cell migration and invasion
PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.
histone lysine demethylase PHF8
, jumonji C domain-containing histone demethylase 1F