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NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. 再加上，我们可以发NCF2 抗体 (50) 和 NCF2 蛋白 (12)和数多这个蛋白质的别的产品。
analysis of NCF2, BCKDHB (显示 BCKDHB ELISA试剂盒) and BCKDHA (显示 BCKDHA ELISA试剂盒) in pig
We analyzed the clinical and laboratory findings of CGD (显示 CYBB ELISA试剂盒) with mutations in the NCF2 gene from amongst our cohort of CGD (显示 CYBB ELISA试剂盒) patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.
All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.
Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (显示 NCF4 ELISA试剂盒) and p67phox at the phagosomal membrane.
TLR4 (显示 TLR4 ELISA试剂盒)- and TLR2 (显示 TLR2 ELISA试剂盒)-induced IRAK (显示 IRAK1 ELISA试剂盒)-ERK (显示 EPHB2 ELISA试剂盒) pathway cross-talks with p67phox-Nox-2 (显示 CYBB ELISA试剂盒) for reactive oxygen species generation, thus regulating IL-1beta (显示 IL1B ELISA试剂盒) transcription and processing in monocytic cells.
Skeletal muscle protein expression of the NADPH oxidase (显示 NOX1 ELISA试剂盒) subunits p22(phox (显示 CYBA ELISA试剂盒)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (显示 CYBA ELISA试剂盒)) and p67(phox) expression was attenuated by exercise training in obese subjects.
A novel homozygous mutation in NCF2.
results reveal an essential role for the Cys (显示 DNAJC5 ELISA试剂盒)-Gly-Cys (显示 DNAJC5 ELISA试剂盒) triad in Nox2 (显示 CYBB ELISA试剂盒) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (显示 DNAJC5 ELISA试剂盒)-Gly-Cys (显示 DNAJC5 ELISA试剂盒). The 2 regions interact with distinct partner sites in p67(phox).
This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (显示 NCF4 ELISA试剂盒)/VAV1 (显示 VAV1 ELISA试剂盒)/RAC1 NADPH oxidase (显示 NOX1 ELISA试剂盒) complex.
Data indicate that arachidonic acid induces the direct interaction of Rac (显示 AKT1 ELISA试剂盒)-GTP (显示 AK3 ELISA试剂盒)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (显示 NOX1 ELISA试剂盒) Nox2 (显示 CYBB ELISA试剂盒).
Four novel mutations in the NCF1 (显示 NCF1 ELISA试剂盒), NCF2, and CYBB (显示 CYBB ELISA试剂盒) genees have been identified in chronic granulomatous disease patients in Morocco.
Just as patients with chronic granulomatous disease who lack NADPH oxidase (显示 NOX1 ELISA试剂盒) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.
p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (显示 PLA2G2A ELISA试剂盒) activity, an interaction that could function to terminate the PLA2 (显示 PLA2G2A ELISA试剂盒)-mediated NOX2 (显示 CYBB ELISA试剂盒) activation signal.
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (显示 FDXR ELISA试剂盒) oxidasesubunit (67kDa (显示 RPSA ELISA试剂盒)) and the resultant metabolic oxidative stress.
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (显示 CYBB ELISA试剂盒)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (显示 SLC2A4 ELISA试剂盒)-/-) mice.
This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.
This study demonstrates the involvement of ROS (显示 ROS1 ELISA试剂盒) from NADPH oxidase (显示 NOX1 ELISA试剂盒) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (显示 PKCd ELISA试剂盒)- and ERK (显示 EPHB2 ELISA试剂盒)-dependent pathways.
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
, neutrophil cytosolic factor 2
, neutrophil cytosol factor 2
, predicted neutrophil cytosolic factor 2
, NADPH oxidase cytosolic protein p67phox
, NADPH oxidase cytosolic protein
, 67 kDa neutrophil oxidase factor
, NADPH oxidase activator 2
, chronic granulomatous disease, autosomal 2
, neutrophil NADPH oxidase factor 2
, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
, NADPH oxidase subunit (67 kD)
, NADPH oxidase subunit (67kDa)