Mycn (MYCN) ELISA试剂盒

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. 再加上,我们可以发MYCN 抗体 (96)MYCN 蛋白 (10)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
MYCN 4613 P04198
MYCN 298894 Q63379
MYCN 18109 P03966

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3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Log in to see 9至12个工作日
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大鼠 0.312-20 ng/mL   96 Tests Log in to see 24至29个工作日
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适于 MYCN 相互作用对的更多 ELISA 试剂盒

Human Mycn (MYCN) interaction partners

  1. our results identify DOT1L (显示 DOT1L ELISA试剂盒) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (显示 ARHGEF16 ELISA试剂盒) oncogenesis. Furthermore, they characterize DOT1L (显示 DOT1L ELISA试剂盒) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (显示 ARHGEF16 ELISA试剂盒).

  2. CCCTC-binding factor (CTCF (显示 CTCF ELISA试剂盒)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (显示 ARHGEF16 ELISA试剂盒) (NB) cells.

  3. PAX3 (显示 PAX3 ELISA试剂盒)-FOXO1 (显示 FOXO1 ELISA试剂盒) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

  4. The findings reveal a PLK1 (显示 PLK1 ELISA试剂盒)-Fbw7 (显示 FBXW7 ELISA试剂盒)-Myc (显示 MYC ELISA试剂盒) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 ELISA试剂盒) inhibitors, alone or with Bcl2 (显示 BCL2 ELISA试剂盒) antagonists, as potential effective therapeutics for MYC (显示 MYC ELISA试剂盒)-overexpressing cancers.

  5. Results show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  6. Rac (显示 AKT1 ELISA试剂盒) activity may be an important determinant of metastatic capability in subsets of neuroblastoma (显示 ARHGEF16 ELISA试剂盒) cells lacking MYCN amplification.

  7. MYCN Gene Amplification is associated with Neuroblastoma (显示 ARHGEF16 ELISA试剂盒).

  8. MYCN overexpression combined with activated anaplastic lymphoma kinase (ALK (显示 ALK ELISA试剂盒)) is sufficient to induce neuroblastoma (显示 ARHGEF16 ELISA试剂盒) (NB) in mouse sympathoadrenal cells

  9. MYCN amplification can be heterogeneous between tumor sites, during tumor progression or following treatment, challenging the notion that MYCN copy number does not change for a particular neuroblastoma (显示 ARHGEF16 ELISA试剂盒).

  10. High MycN expression is associated with low radiosensitivity in neuroblastoma (显示 ARHGEF16 ELISA试剂盒).

Mouse (Murine) Mycn (MYCN) interaction partners

  1. a Mycn target gene encoding the miR (显示 MLXIP ELISA试剂盒) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  2. The findings reveal a PLK1 (显示 PLK1 ELISA试剂盒)-Fbw7 (显示 FBXW7 ELISA试剂盒)-Myc (显示 MYC ELISA试剂盒) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 ELISA试剂盒) inhibitors, alone or with Bcl2 (显示 BCL2 ELISA试剂盒) antagonists, as potential effective therapeutics for MYC (显示 MYC ELISA试剂盒)-overexpressing cancers.

  3. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (显示 MMRN1 ELISA试剂盒)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  4. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  5. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (显示 ARHGEF16 ELISA试剂盒), and is a promising approach for further clinical development.

  6. demonstrate a critical link between Myc (显示 MYC ELISA试剂盒)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal

  7. Loss of N-myc significantly impairs the Sonic hedgehog (显示 SHH ELISA试剂盒) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (显示 CCND2 ELISA试剂盒).

  8. Study shows that ground-state embryonic stem cells express low Myc (显示 MYC ELISA试剂盒) levels. Deletion of both c-myc (显示 MYC ELISA试剂盒) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (显示 MYC ELISA试剂盒)-depleted stem cells enter a state of dormancy.

  9. MYCN overexpression is not sufficient for these cells to form tumors in nude mice

  10. ITGA4 (显示 ITGA4 ELISA试剂盒) expression enhances metastasis in MYCN low neuroblastoma (显示 ARHGEF16 ELISA试剂盒).

MYCN 抗原简介

Antigen Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with Mycn (MYCN) ELISA试剂盒

  • olfactory receptor, family 8, subfamily S, member 1-like (LOC515887) 抗体
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) 抗体
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (Mycn) 抗体
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (MYCN) 抗体
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) 抗体
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (Mycn) 抗体
  • bHLHe37 抗体
  • c-nmyc 抗体
  • MODED 抗体
  • MYCNOT 抗体
  • N-myc 抗体
  • Nmuc1 抗体
  • Nmyc 抗体
  • Nmyc-1 抗体
  • Nmyc1 抗体
  • ODED 抗体

Protein level used designations for Mycn (MYCN) ELISA试剂盒

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc protein , neuroblastoma myc-related oncogene 1

GENE ID SPECIES
515887 Bos taurus
4613 Homo sapiens
298894 Rattus norvegicus
421948 Gallus gallus
482978 Canis lupus familiaris
18109 Mus musculus
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