Mycn (MYCN) ELISA试剂盒

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. 再加上,我们可以发MYCN 抗体 (98)MYCN 蛋白 (7)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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适于 MYCN 相互作用对的更多 ELISA 试剂盒

Human Mycn (MYCN) interaction partners

  1. Common genetic variation predisposes to different neuroblastoma (显示 ARHGEF16 ELISA试剂盒) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]

  2. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (显示 RB1 ELISA试剂盒) gene.

  3. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (显示 ARHGEF16 ELISA试剂盒), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (显示 ARHGEF16 ELISA试剂盒).

  4. Many prognostic signatures for neuroblastoma (显示 ARHGEF16 ELISA试剂盒) are confounded by MYCN amplification.

  5. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  6. miR (显示 MLXIP ELISA试剂盒)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (显示 CADM1 ELISA试剂盒), and an inverse correlation between miR (显示 MLXIP ELISA试剂盒)-21 and CADM1 (显示 CADM1 ELISA试剂盒) expression in vivo. MiR (显示 MLXIP ELISA试剂盒)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  7. LMO1 (显示 LMO1 ELISA试剂盒) is an important oncogene (显示 RAB1A ELISA试剂盒) that promotes neuroblastoma (显示 ARHGEF16 ELISA试剂盒) initiation, progression, and widespread metastatic dissemination.

  8. our results identify DOT1L (显示 DOT1L ELISA试剂盒) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (显示 ARHGEF16 ELISA试剂盒) oncogenesis. Furthermore, they characterize DOT1L (显示 DOT1L ELISA试剂盒) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (显示 ARHGEF16 ELISA试剂盒).

  9. CCCTC-binding factor (CTCF (显示 CTCF ELISA试剂盒)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (显示 ARHGEF16 ELISA试剂盒) (NB) cells.

  10. PAX3 (显示 PAX3 ELISA试剂盒)-FOXO1 (显示 FOXO1 ELISA试剂盒) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

Mouse (Murine) Mycn (MYCN) interaction partners

  1. beta-catenin (显示 CTNNB1 ELISA试剂盒) cooperates with the transcription factor Myc (显示 MYC ELISA试剂盒) to activate the progenitor renewal program.

  2. we report the isolation and propagation of neuroblastoma (显示 ARHGEF16 ELISA试剂盒) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (显示 ARHGEF16 ELISA试剂盒) with MYCN amplification

  3. miR (显示 MLXIP ELISA试剂盒)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  4. the role of N-myc in mouse lens development, was examined.

  5. Using comparative genomic hybridization, authors found that NCC (显示 SLC12A3 ELISA试剂盒)-derived NBL (显示 NUMBL ELISA试剂盒) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (显示 NUMBL ELISA试剂盒) including 17q gain, 2p gain and loss of 1p36.

  6. a Mycn target gene encoding the miR (显示 MLXIP ELISA试剂盒) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  7. The findings reveal a PLK1 (显示 PLK1 ELISA试剂盒)-Fbw7 (显示 FBXW7 ELISA试剂盒)-Myc (显示 MYC ELISA试剂盒) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 ELISA试剂盒) inhibitors, alone or with Bcl2 (显示 BCL2 ELISA试剂盒) antagonists, as potential effective therapeutics for MYC (显示 MYC ELISA试剂盒)-overexpressing cancers.

  8. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (显示 MMRN1 ELISA试剂盒)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  9. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  10. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (显示 ARHGEF16 ELISA试剂盒), and is a promising approach for further clinical development.

Zebrafish Mycn (MYCN) interaction partners

  1. In MYCN transgenic fish, Gab2 (显示 GAB2 ELISA试剂盒) overexpression activated the Shp2 (显示 PTPN11 ELISA试剂盒)-Ras (显示 RAB1A ELISA试剂盒)-Erk (显示 MAPK1 ELISA试剂盒) pathway, enhanced neuroblastoma (显示 ARHGEF16 ELISA试剂盒) induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (显示 NF1 ELISA试剂盒) loss leads to aberrant activation of RAS (显示 RAB1A ELISA试剂盒) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (显示 ARHGEF16 ELISA试剂盒) in nf1 (显示 NF1 ELISA试剂盒)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (显示 NF1 ELISA试剂盒) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN 抗原简介

Antigen Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with Mycn (MYCN) ELISA试剂盒

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) 抗体
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) 抗体
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) 抗体
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) 抗体
  • olfactory receptor 8S1 (LOC515887) 抗体
  • MYCN proto-oncogene, bHLH transcription factor (mycn) 抗体
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) 抗体
  • bHLHe37 抗体
  • c-nmyc 抗体
  • fb57a02 抗体
  • MODED 抗体
  • mycn 抗体
  • mycn-a 抗体
  • mycn-b 抗体
  • mycna 抗体
  • MYCNOT 抗体
  • N-myc 抗体
  • Nmuc1 抗体
  • Nmyc 抗体
  • Nmyc-1 抗体
  • nmyc1 抗体
  • ODED 抗体
  • wu:fb57a02 抗体
  • XN-myc 抗体
  • xN-myc1 抗体
  • XNmyc 抗体
  • zgc:85706 抗体

Protein level used designations for Mycn (MYCN) ELISA试剂盒

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPECIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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