MDS1 and EVI1 Complex Locus (MECOM) ELISA试剂盒

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. 再加上,我们可以发MDS1 and EVI1 Complex Locus 抗体 (118)MDS1 and EVI1 Complex Locus 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
大鼠 MECOM MECOM 294924  

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适于 MDS1 and EVI1 Complex Locus 相互作用对的更多 ELISA 试剂盒

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (显示 NOTCH1 ELISA试剂盒) signaling

  2. Prdm3 and prdm16 (显示 PRDM16 ELISA试剂盒) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. discussion of the role of RUNX1 (显示 RUNX1 ELISA试剂盒) in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1 (显示 RUNX1 ELISA试剂盒)+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 (显示 RUNX1 ELISA试剂盒) expression

  3. deficiency alters the expression of a crucial subset of TAL1 (显示 TAL1 ELISA试剂盒)- and NOTCH1 (显示 NOTCH1 ELISA试剂盒)-regulated genes, including the MYB (显示 MYB ELISA试剂盒) and MYC (显示 MYC ELISA试剂盒) oncogenes, respectively.

  4. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (显示 ETS1 ELISA试剂盒)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  5. Our findings strengthen previous data concerning RUNX1 (显示 RUNX1 ELISA试剂盒) mutations in acute myeloid leukemia (显示 BCL11A ELISA试剂盒) and support the notion that RUNX1 (显示 RUNX1 ELISA试剂盒) mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (显示 BCL11A ELISA试剂盒).

  6. Heterozygous germ line mutations in the RUNX1 (显示 RUNX1 ELISA试剂盒) gene are responsible genetic events for FPD/AML (显示 RUNX1 ELISA试剂盒).

  7. Data suggest that RUNX1 (显示 RUNX1 ELISA试剂盒) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (显示 RUNX1 ELISA试剂盒), either mutations in RUNX1 (显示 RUNX1 ELISA试剂盒) gene or variations in expression of RUNX1 (显示 RUNX1 ELISA试剂盒), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  8. The E3 ubiquitin ligase STUB1 (显示 STUB1 ELISA试剂盒) is a negative regulator of both RUNX1 (显示 RUNX1 ELISA试剂盒) and RUNX1 (显示 RUNX1 ELISA试剂盒)-RUNX1T1 (显示 RUNX1T1 ELISA试剂盒). Activation of STUB1 (显示 STUB1 ELISA试剂盒) could be a promising therapeutic strategy for RUNX1 (显示 RUNX1 ELISA试剂盒)-RUNX1T1 (显示 RUNX1T1 ELISA试剂盒) leukemia.

  9. The clinical significance of ETV6 (显示 ETV6 ELISA试剂盒)-RUNX1 (显示 RUNX1 ELISA试剂盒).

  10. Deliver the necessary promotional drive for the progression of ETV6 (显示 ETV6 ELISA试剂盒)-RUNX1 (显示 RUNX1 ELISA试剂盒)+ pre-leukaemic cells.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (显示 GATA2 ELISA试剂盒) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (显示 CEBPA ELISA试剂盒) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (显示 CSF2 ELISA试剂盒), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (显示 CSF2 ELISA试剂盒) levels.

  5. Survivin (显示 BIRC5 ELISA试剂盒) partially regulates HSC (显示 FUT1 ELISA试剂盒) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (显示 THPO ELISA试剂盒)/MPL (显示 MPL ELISA试剂盒) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (显示 PRDM16 ELISA试剂盒) and Prdm3 control postnatal BAT (显示 BAAT ELISA试剂盒) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (显示 MLL ELISA试剂盒)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (显示 CEBPB ELISA试剂盒), liver inhibitory protein (LIP), induced acute myeloid leukemia (显示 BCL11A ELISA试剂盒) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) 抗原简介

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) 抗体
  • MDS1 and EVI1 complex locus (MECOM) 抗体
  • MDS1 and EVI1 complex locus (LOC100343228) 抗体
  • MDS1 and EVI1 complex locus (Mecom) 抗体
  • runt-related transcription factor 1 (RUNX1) 抗体
  • AML1 抗体
  • AML1-EVI-1 抗体
  • AMLCR1 抗体
  • CBFA2 抗体
  • D630039M04Rik 抗体
  • EVI-1 抗体
  • Evi1 抗体
  • im:7140716 抗体
  • Jbo 抗体
  • Mds 抗体
  • Mds1 抗体
  • Mds1-Evi1 抗体
  • PEBP2aB 抗体
  • Prdm3 抗体
  • Znfpr1b1 抗体

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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