Lysyl Oxidase-Like 1 蛋白 (LOXL1)

LOXL1 encodes a member of the lysyl oxidase gene family. 再加上,我们可以发LOXL1 抗体 (75)LOXL1 试剂盒 (17)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
LOXL1 4016 Q08397
LOXL1 16949 P97873
LOXL1 315714  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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大肠杆菌(E. Coli) His tag   50 μg Log in to see 11 Days
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大肠杆菌(E. Coli) 小鼠 His tag,T7 tag 100 μg Log in to see 15至18个工作日
大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
大肠杆菌(E. Coli) 非结合性   5 applications Log in to see 1至2个工作日

LOXL1 蛋白 by Origin and Source

Origin 在表达 标记
Human ,

Mouse (Murine) , ,
Rat (Rattus)

更多Lysyl Oxidase-Like 1 (LOXL1)互动伙伴

Rhesus Monkey Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. high lysyl oxidase (显示 LOX 蛋白) activity is associated with ischemic hearts.

Human Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. These findings provide evidence for a functional role of alternative splicing coupled to NMD in the posttranscriptional regulation of LOXL1 gene expression and suggest this mechanism to represent a dynamic mode of adapting LOXL1 expression to PEX (显示 PHEX 蛋白)-associated environmental and nutritional cues.

  2. remenopausal and postmenopausal women with Pelvic Organ Prolapse (POP (显示 PREP 蛋白)) exhibit differential expression of LOXL1 suggesting different pathways in the pathogenesis of POP (显示 PREP 蛋白). The role of biopsy location on LOXL1 expression requires further investigation.

  3. In this study, we found no significant association between allele and genotype frequencies of APOE (显示 APOE 蛋白); the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.

  4. The LOXL1 SNPs, rs1048661 and rs3825942, are associated with PXF (显示 PEX19 蛋白) in the South Indian population correlating with lowered LOX (显示 LOX 蛋白) activity in the aqueous humor. The increased level of total TGF-beta (显示 TGFB1 蛋白) in the aqueous humor of PXF (显示 PEX19 蛋白) cases is possibly associated with LOX (显示 LOX 蛋白) regulation which needs further investigation.

  5. A rare protective allele at LOXL1,Tyr407Phe, was identified. It is found exclusively in the Japanese population. It confers 25-fold resistance to XFS (显示 FST 蛋白). It segregated with the common rs3825942[A] (p.Asp153) in all but 2 patients examined. In spheroids, this haplotype conferred a significant increase in the strength of cellular adhesion in comparison to 3 haplotypes with the wild-type allele.

  6. Findings of this current study indicate a different LOXL1 gene expression pattern compared with a recent study that was also performed in the Turkish population.

  7. LOXL1 transcriptional activity was dramatically reduced when a recombinant DNMT3A (显示 DNMT3A 蛋白) was concomitantly overexpressed.

  8. The present study, for the first time, shows that the pseudoexfoliation syndrome-associated variant residues in LOXL1 influence processing of the protein, most likely by BMP-1 (显示 BMP1 蛋白).

  9. In this study group of Turkish population, no LOXL1 mutations were found. No associations between the defined SNPs (A320A, R141L and F184F) and the severity of the disease were detected.

  10. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX (显示 LOX 蛋白) and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue

Cow (Bovine) Lysyl Oxidase-Like 1 (LOXL1) interaction partners

Mouse (Murine) Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females

  2. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.

  3. There is a possible fundamental role of LOXL-1 in cardiac hypertrophy.

  4. loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype

  5. Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted (显示 MUTED 蛋白) long-term potentiation compared to LOXL +/+ mice.

  6. pro-regions of lysyl oxidase (显示 LOX 蛋白) and lysyl oxidase-like 1 are required for deposition onto elastic fibers

  7. LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders

  8. LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues

  9. LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin (显示 ELN 蛋白) disorganization may lead to such functional abnormalities.

  10. Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility.



This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Gene names and symbols associated with Lysyl Oxidase-Like 1 蛋白 (LOXL1)

  • lysyl oxidase like 1 (LOXL1)
  • lysyl oxidase like 1 (loxl1)
  • lysyl oxidase-like 1 (Loxl1)
  • lysyl oxidase-like 1 (loxl1)
  • lysyl oxidase like 1 L homeolog (loxl1.L)
  • lol 蛋白
  • loxl 蛋白
  • loxl-1 蛋白
  • oxl-1 蛋白
  • si:ch211-238c15.1 蛋白

Protein level used designations for Lysyl Oxidase-Like 1 蛋白 (LOXL1)

lysyl oxidase-like 1 , lysyl oxidase homolog 1-like , lysyl oxidase homolog 1 , lysyl oxidase-like protein 1 , lysyl oxidase 2

426411 Gallus gallus
706464 Macaca mulatta
100051862 Equus caballus
100124878 Xenopus (Silurana) tropicalis
100388123 Callithrix jacchus
100606325 Nomascus leucogenys
4016 Homo sapiens
281903 Bos taurus
16949 Mus musculus
315714 Rattus norvegicus
560115 Danio rerio
496210 Xenopus laevis
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