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The protein encoded by LTK is a member of the ros/insulin receptor family of tyrosine kinases.
In hippocampus, Ltk and Alk (anaplastic lymphoma kinase (显示 ALK ELISA试剂盒)) are expressed throughout dentate gyrus, CA1 (显示 CA1 ELISA试剂盒), and CA3 (显示 CA3 ELISA试剂盒). Data suggest genetic interactions between Ltk and Alk (显示 ALK ELISA试剂盒) in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory).
polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
LAR (显示 PTPRF ELISA试剂盒) regulates Fyn (显示 FYN ELISA试剂盒)/JAK2 (显示 JAK2 ELISA试剂盒)/STAT3 (显示 STAT3 ELISA试剂盒) and Fyn (显示 FYN ELISA试剂盒)/p38 MAPK (显示 MAPK14 ELISA试剂盒) pathways involved in ROS (显示 ROS1 ELISA试剂盒)-induced apoptosis
Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants.
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons.
leukocyte receptor tyrosine kinase
, leukocyte tyrosine kinase receptor