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The protein encoded by ITPA hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. 再加上，我们可以发Inosine Triphosphatase 蛋白 (24) 和 Inosine Triphosphatase 试剂盒 (12)和数多这个蛋白质的别的产品。
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Human Monoclonal ITPA Primary Antibody for ELISA - ABIN517268
Vroemen, Munnix, Bakker, Bierau, Huts, Leers: A novel multiparameter flow cytometric assay for inosine triphosphatase expression analysis in leukocytes. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012
Inosine triphosphatase (IPTA) rs1127354 variants but not rs7270101 were found in Chinese patients infected with chronic hepatitis C. IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the virological response to pegylated interferon (显示 IFNA 抗体) plus ribavirin combination therapy in Chinese chronic hepatitis C virus-infected patients.
This study concluded that HIV-infection seems to be interfering with the nucleotide metabolism in leukocytes, including CD4 (显示 CD4 抗体) lymphocytes, by decreasing ITPase expression, independently of ITPA genotype.
A high prevalence of the ITPA polymorphisms associated with ribavirin-induced hemolytic anemia was found in Mexican Native Amerindians.
ITPA gene is associated with protection of anemia in patients with chronic hepatitis during antiviral therapy.
We concluded that ITPase activity plays an important function and that ATP concentration changes due to therapy are related to the Hb decreasing mechanism in the early period of therapy with HCV treatment
The aim of the study was to investigate frequencies of TPMT (显示 TPMT 抗体) and ITPA polymorphisms in Lithuanian inflammatory bowel disease patients and analyze their association with azathioprine-related adverse events.
ITPA polymorphism was associated with RBV-induced anemia and thrombocytopenia in Egyptian patients with hepatitis C virus genotype 4 infection.
Hyperbilirubinemia develops at early time points after simeprevir administration in most cases and is dependent on the ITPA genotype.
Genetic variants in inosine triphosphatase (ITPA) gene have been linked to the haemolytic anaemia induced by peg (显示 PAEP 抗体)-interferon (显示 IFNA 抗体) and ribavirin treatment.
The association of IL28B (显示 IL28B 抗体) and APOH (显示 APOH 抗体) single nucleotide polymorphisms (SNPs) with sustained virological response and of ITPA SNPs with anemia related phenotypes.
In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns.
The role of ITPase in mice is to exclude ITP from the ATP pool, and the main target substrate of this enzyme is rITP
This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.
inosine triphosphate pyrophosphatase
, inosine triphosphatase
, inosine triphosphatase-A
, inosine triphosphate pyrophosphohydrolase
, non-canonical purine NTP pyrophosphatase
, non-standard purine NTP pyrophosphatase
, nucleoside-triphosphate diphosphatase
, putative oncogene protein HLC14-06-P
, nucleoside-triphosphate pyrophosphatase
, nucleoside triphosphate pyrophosphatase
, inosine triphosphatase A
, Non-canonical purine NTP pyrophosphatase
, Non-standard purine NTP pyrophosphatase
, Nucleoside-triphosphate diphosphatase
, Nucleoside-triphosphate pyrophosphatase
, Inosine triphosphatase
, hypothetical protein
, cancer-related nucleoside-triphosphatase
, human cancer-related NTPase
, nucleoside triphosphate phosphohydrolase
, nucleoside-triphosphatase C1orf57