Heat Shock Protein 70 蛋白 (HSP70)

heat shock protein\; may have an important role following forebrain ischemia and may allow astrocytes to protect neurons [RGD, Feb 2006].. 再加上,我们可以发HSP70 抗体 (746)HSP70 试剂盒 (74)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HSP70 3308 P34932
小鼠 HSP70 HSP70 15511 P17879
大鼠 HSP70 HSP70 266759 O88600

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HSP70 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
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引用最多的HSP70 蛋白

  1. Human HSP70 Protein expressed in Escherichia coli (E. coli) - ABIN1686670 : Zou, Guo, Guettouche, Smith, Voellmy: Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. in Cell 1998 (PubMed)
    Show all 12 references for 1686670

  2. Human HSP70 Protein expressed in Baculovirus - ABIN1686688 : Rothman: Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells. in Cell 1990 (PubMed)
    Show all 8 references for 1686688

  3. Human HSP70 Protein expressed in Baculovirus - ABIN1686694 : Boorstein, Ziegelhoffer, Craig: Molecular evolution of the HSP70 multigene family. in Journal of molecular evolution 1994 (PubMed)
    Show all 6 references for 1686694

  4. Human HSP70 Protein expressed in Escherichia coli (E. coli) - ABIN666857 : Gething, Sambrook: Protein folding in the cell. in Nature 1992 (PubMed)
    Show all 2 references for 666857

  5. Human HSP70 Protein expressed in Escherichia coli (E. coli) - ABIN593443 : Mosenson, Zloza, Nieland, Garrett-Mayer, Eby, Huelsmann, Kumar, Denman, Lacek, Kohlhapp, Alamiri, Hughes, Bines, Kaufman, Overbeck, Mehrotra, Hernandez, Nishimura, Guevara-Patino, Le Poole: Mutant HSP70 reverses autoimmune depigmentation in vitiligo. in Science translational medicine 2013 (PubMed)

更多Heat Shock Protein 70 (HSP70)互动伙伴

Arabidopsis thaliana Heat Shock Protein 70 (HSP70) interaction partners

  1. ability of multiple unrelated Hsp70-binding elements to support protein import verified that the majority of TPs utilize an N-terminal Hsp70-binding domain during translocation and expand the mechanistic view of the import process

  2. temperature regulated expression of AtHSP70-4 may be mediated by cell cycle transcription factors and participate in plant acclimations to non-stress temperature changes

  3. This work describes a detailed quantitative interaction study between the novel plastidial chaperone receptor OEP61 and isoforms of the chaperone types Hsp70 and Hsp90 (显示 HSP90 蛋白) using the optical method of total internal reflection ellipsometry.

  4. Hsp70-14 and Hsp70-15 silenced plants display an altered stomatal response and a constitutive heat stress phenotype.

  5. Chloroplasts have two chaperone systems facilitating protein translocation into the stroma: the cpHsc70 system and the Hsp93/Tic40 system.

  6. A working hypothesis is that Hsp70 has a defense-promoting activity(s) that HopI1 or high temperature can subvert.

  7. Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome (显示 Psmd4 蛋白) system.

  8. The MAPK (显示 MAPK1 蛋白)-EGR-1 (显示 EGR1 蛋白)-HSP70 pathway regulates the cigarette smoke-induced inflammatory process.

Human Heat Shock Protein 70 (HSP70) interaction partners

  1. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin (显示 PARK2 蛋白) Function. Heat shock protein members may act as compensatory factors for parkin (显示 PARK2 蛋白) loss of function and that the exploitation of these factors may be of potential therapeutic value.

  2. targeting the Hsp70 induction in Hsp90 (显示 HSP90 蛋白) inhibitor-treated cancer cells and tumor vasculature cells may beneficially enhance the radiosensitizing effect

  3. The interaction of Fas receptor (显示 FAS 蛋白) with FasL (显示 FASL 蛋白) leads to an activation of the Tag7 (显示 PGLYRP1 蛋白)-Hsp70 complex in the lymphocyte membrane fraction, and here FasL (显示 FASL 蛋白) acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA (显示 MICA 蛋白) stress ligand with the NKG2D (显示 KLRK1 蛋白) receptor is necessary for the release of this cytotoxic complex

  4. Triptolide downregulates Sp1 (显示 PSG1 蛋白) and HSP70 mRNA in gastric cancer cell lines.

  5. HSP70-TRIM32 (显示 TRIM32 蛋白) complex is biochemically distinct from the previously characterized 14-3-3 (显示 YWHAQ 蛋白)-TRIM32 (显示 TRIM32 蛋白) phospho-complex.

  6. There is overwhelming evidence that molecular chaperones such as Hsp27 (显示 HSPB1 蛋白), Hsp70 and Hsp90 (显示 HSP90 蛋白) are expressed at elevated levels in a wide range of cancers by stabilizing the mutated neoplasm proteins. (Review)

  7. HSP70 is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle.

  8. we demonstrated that upregulation of heat shock protein 70 (HSP70) was involved in both the promoted migration and the inhibited apoptosis of HepG2 cells in response to TNFalpha (显示 TNF 蛋白). Collectively, these findings indicate that TNFalpha (显示 TNF 蛋白) alters protein expression such as HSP70, which triggering specific molecular processes and signaling cascades that promote migration and inhibit apoptosis of HepG2 cells.

  9. The authors show here that both Escherichia coli ClpB and Saccharomyces cerevisiae Hsp104 cooperation with their cognate Hsp70 is crucial for efficient protein disaggregation and, in contrast to earlier claims, cannot be circumvented by activating M-domain mutations.

  10. SIRT1 (显示 SIRT1 蛋白) inhibits the releases of HMGB1 (显示 HMGB1 蛋白) and HSP70 from human umbilical vein endothelial cells caused by IL-6 (显示 IL6 蛋白) and the serum from preeclampsia patient and protects the cells from death.

Mouse (Murine) Heat Shock Protein 70 (HSP70) interaction partners

  1. Data show that Klotho (显示 KL 蛋白) protein is present in the heart, and reduced levels of myocardial Klotho (显示 KL 蛋白) in aging mice is accompanied by lower levels heat shock protein 70 (HSP70) in the myocardium.

  2. analysis of the intracellular pathways implicated in Hsp70 regulated signal transduction showed the involvement of both PI3K/AKT (显示 AKT1 蛋白) and NF-kappaB (显示 NFKB1 蛋白).

  3. HSPA1A (显示 HSPA1A 蛋白)/B induction is a novel approach to delay thrombus formation with minimal bleeding risk in knockout mice

  4. Hsp70 expression was observed trophoblast cells and decidual cells and was relatively constant throughout the pregnancy.

  5. The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7 (显示 PGLYRP1 蛋白)-Hsp70 and the Tag 7 (显示 PGLYRP1 蛋白) component of this complex with TNFR1 (显示 TNFRSF1A 蛋白) receptor in solution and in tumor cells are presented.

  6. the protective effect of HSP70 may be associated with inhibition of NF-kappaB and stimulation of NOS/NO signaling pathways

  7. activation of the HSP70-TLR4 (显示 TLR4 蛋白) axis, stimulated at least in part by albumin (显示 ALB 蛋白), in the tubular cell is a newly identified mechanism associated with induction of tubulointerstitial inflammation.

  8. Studied the protein expression of BCL2 (显示 BCL2 蛋白), FGF-R1, and HSP70 after short-time magnetic thermoablative tumor treatment using immunohistochemistry in a human BT474 breast cancer mouse xenograft model.

  9. Knockdown lines were created for specific DSBs in regions of the chromosome that are coding for HSPA1B. Clonogenic cell survival was significantly lower in irradiated Hsp70 KD cells with low mHsp70 expression, than in ctrl cells.

  10. Hsp70.1 (显示 HSPA1A PLURAL_@33193@)-deficient mice were more resistant to developing experimental autoimmune encephalomyelitis (EAE) compared with their wild-type littermates, suggesting Hsp70.1 (显示 HSPA1A PLURAL_@33193@) plays a role in promoting myelin oligodendrocyte glycoprotein (显示 MOG PLURAL_@33193@) specific T cell response.

Pig (Porcine) Heat Shock Protein 70 (HSP70) interaction partners

  1. There was a significant decrease in the systemic HSP70 levels of trauma groups (moderate and severe hemorrhage) when compared to the sham trauma group, which was significantly decreased compared to baseline values in severe hemorrhage over the entire time course.

  2. Host HSP70 and Classical swine fever virus NS5A protein complex formation is confirmed by coimmunoprecipitation and GST-pulldown studies.

  3. This study evaluated the expression of 70kDa (显示 RPS6KB1 蛋白) heat shock proteins and the concentration of thiobarbituric acid reactive substances and nitric oxide ions as markers of oxidative stress in swine.

  4. This study revealed that HSP70 is an essential host factor required for the replication of porcine reproductive and respiratory syndrome virus.

  5. A specific interaction between Hsp70 and porcine circovirus type 2 Cap (capsid protein) was confirmed by colocalization by confocal microscopy and co-immunoprecipitation.

  6. This work investigated the expression of heat shock protein 70 by Western blot in swine liver. Animals in an intensive/indoor confinement system showed significantly higher HSP70 values compared with those in an extensive/outdoor system.

  7. The results indicate that Heat shock protein 70 (Hsp70) mediates distinct stress-related functions in different tissues during transportation. Heat shock factor-1 (HSF-1) levels were reduced at 1 and 4 h only in the hearts of transported pigs.

  8. These results indicated that the expression of Hsp70 in the intestinal piglets was upregulated by IUGR, and different intestinal sites had different responses to stress.

  9. Induction of tolerance to heat shock correlated with the induced expression of heat shock protein 70. HSP70 and compatible osmolytes have distinct roles in cellular adaptation to these stresses.

  10. HSP-70 is an endogenous protectant of which its actions may be unmasked and/or potentiated with exogenous administration before brain injury

Tomato (Solanum lycopersicum) Heat Shock Protein 70 (HSP70) interaction partners

  1. Experimental evidence show: apoptozole forms aggregates under aqueous conditions that could interact with HSP70 proteins in a non-specific manner.

  2. Disrupts the Hsp70-Bag3 (显示 BAG3 蛋白) interaction.

  3. Increased Hsp70 expression levels are associated with squamous cell carcinoma of the head and neck.

  4. Hsp70 and Hsp90 (显示 HSP90 蛋白) chaperones coregulate heat shock gene expression within a network of mutual, but factor-specific, interactions with heat stress transcription factors.

  5. salicylic acid-mediated potentiation of Hsp70 is due to modulation of heat shock factors by salicylic acid.

蛋白简介HSP70

蛋白简介

heat shock protein\; may have an important role following forebrain ischemia and may allow astrocytes to protect neurons

Gene names and symbols associated with Heat Shock Protein 70 蛋白 (HSP70)

  • heat shock 70 kD protein cognate (LOC692373)
  • heat shock protein 70-2 (CPHSC70-2EAT SHOCK PROTEIN 70-2)
  • Heat shock protein 70 (AT1G79920)
  • heat shock protein 70 (HSP70)
  • Heat shock protein 70 (PCC7424_2419)
  • Heat shock protein 70 (Isop_1041)
  • heat shock protein 70 (CGB_C3390W)
  • Heat shock protein 70 (Bacsa_1698)
  • heat shock protein 70 (dnaK-B)
  • heat shock protein 70 (LOC100305036)
  • CG5834 gene product from transcript CG5834-RA (Hsp70Bbb)
  • heat shock 70kDa protein 1A (HSPA1A)
  • heat shock 70kDa protein 2 (HSPA2)
  • heat shock 70kDa protein 4 (HSPA4)
  • heat shock cognate protein 70a (hsc70a)
  • heat shock protein 1B (Hspa1b)
  • heat shock protein 4 (Hspa4)
  • heat shock protein 70-4 (HSP70)
  • heat shock protein1 (hsp1)
  • Protein HSP-70 (hsp-70)
  • APG-2 蛋白
  • ARABIDOPSIS HEAT SHOCK PROTEIN 70 蛋白
  • ATHSP70 蛋白
  • CG5834 蛋白
  • CG31354 蛋白
  • chloroplast heat shock protein 70-2 蛋白
  • cpHsc70-2 蛋白
  • DmelCG5834 蛋白
  • F19K16.12 蛋白
  • F19K16_12 蛋白
  • heat shock protein 70 蛋白
  • HEAT SHOCK PROTEIN 70-7 蛋白
  • HS24/P52 蛋白
  • hsc70 蛋白
  • HSC70-7 蛋白
  • hsc71 蛋白
  • hsp68 蛋白
  • Hsp70 蛋白
  • Hsp70-1 蛋白
  • hsp70-5 蛋白
  • Hsp70.1 蛋白
  • hsp70B 蛋白
  • HSP70B' 蛋白
  • Hsp70Bb 蛋白
  • hsp70Bb-prime 蛋白
  • hsp70RY 蛋白
  • Hsp110 蛋白
  • HSPA1 蛋白
  • HSPA6 蛋白
  • HSPH2 蛋白
  • irp94 蛋白
  • K9P8.5 蛋白
  • K9P8_5 蛋白
  • LOC100305036 蛋白
  • RY 蛋白

Protein level used designations for Heat Shock Protein 70 蛋白 (HSP70)

heat shock 70 kD protein cognate , heat shock protein 70 , hypothetical protein , Heat shock protein 70 , CF Hsp70 , Heat shock cognate 71 kDa protein , Hsp70Bbb , CG5834-PA , Hsp70Bbb-PA , heat shock 70 kDa protein 1A/1B , dnaK-type molecular chaperone , heat shock 70 kDa protein , heat shock 70 kDa protein 4 , heat shock 70-related protein APG-2 , heat shock 70kD protein 4 , heat shock protein, 110 kDa , hsp70 RY , HSP70 , heat shock 70kDa protein 8 , heat shock cognate 70 kDa protein , 68 kDa heat shock protein , heat shock 70 kDa protein 1 , heat shock 70 kDa protein 1B , heat shock 70kDa protein 1B , heat shock protein 70.1 , heat shock protein, 70 kDa 1 , ischemia responsive 94 kDa protein , Heat shock 70 kDa protein 6 , heat shock 70 kDa protein B' , CL45_1 , CL45_1(648) , CL45_1_ov , Heat shock 70 kDa protein , heat shock protein 70 kDa , hsp 70-1 , npi119-hsp1

GENE ID SPECIES
692373 Bombyx mori
835054 Arabidopsis thaliana
844332 Arabidopsis thaliana
3636073 Candida albicans SC5314
3636229 Candida albicans SC5314
7095334 Grapevine leafroll-associated virus 10
7110730 Cyanothece sp. PCC 7424
10155152 Isosphaera pallida ATCC 43644
10187290 Cryptococcus gattii WM276
10259602 Bacteroides salanitronis DSM 18170
10889164 Simkania negevensis Z
100305036 Ictalurus punctatus
50022 Drosophila melanogaster
100913152 Ovis aries
423504 Gallus gallus
3308 Homo sapiens
100135841 Oncorhynchus mykiss
15511 Mus musculus
266759 Rattus norvegicus
403612 Canis lupus familiaris
396906 Sus scrofa
100134914 Solanum lycopersicum
820438 Arabidopsis thaliana
542423 Zea mays
172757 Caenorhabditis elegans
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