Eukaryotic Translation Initiation Factor 4E (EIF4E) ELISA试剂盒

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. 再加上,我们可以发EIF4E 抗体 (258)EIF4E 蛋白 (18)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
EIF4E 1977 P06730
EIF4E 13684 P63073
EIF4E 117045 P63074

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适于 EIF4E 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. The structures of eIF4E-eIF4G (显示 EIF4G1 ELISA试剂盒) complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒) impairs the competition with eIF4G (显示 EIF4G1 ELISA试剂盒) for eIF4E binding.

  3. Both eIF4E-1 and eIF4E-3 (显示 EIF4E3 ELISA试剂盒) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  4. eIF4E-binding protein (显示 EIF4EBP1 ELISA试剂盒) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  5. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  6. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  7. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  8. data are consistent with the idea that Parkin (显示 PARK2 ELISA试剂盒) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  9. results show that LK6 binds to ERK (显示 MAPK1 ELISA试剂盒) and is activated by ERK (显示 MAPK1 ELISA试剂盒) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  10. our results suggest that the level of eIF4E protein is regulated by Diap1 (显示 DIAPH1 ELISA试剂盒), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (显示 CDK1 ELISA试剂盒) and calcineurin regulate Maskin (显示 TACC3 ELISA试剂盒) association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Here, the authors identify the domains responsible for the eIF4E/human rhinovirus 2 2A(pro) interaction using molecular modelling and describe mutations that impair this interaction and delay in vitro cleavage of eIF4G (显示 EIF4G1 ELISA试剂盒) isoforms.

  2. Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation.

  3. There were significantly higher expressions of p-eIF4E and p-4EBP-1 (显示 EIF4EBP1 ELISA试剂盒) proteins in the cases with lymph node metastasis than in those without lymph node metastasis.

  4. Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway.

  5. Human endogenous eIF4E1 and eIF4E2 behave under stresses similarly as their GFP-tagged counterparts.

  6. High EIF4E expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas.

  7. The structures of eIF4E-eIF4G (显示 EIF4G1 ELISA试剂盒) complexes reveal an extended interface to regulate translation initiation.

  8. 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒) has tumor suppressor activity by inhibiting eIF4E and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒), which are detected in various cancers

  9. The studies suggest that MNK (显示 ATP7A ELISA试剂盒)-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1 (显示 CYFIP1 ELISA试剂盒). (Review)

  10. Alternative eIF4F (显示 EIF4A2 ELISA试剂盒) complexes taking part in protein biosynthesis have been described. (Review)

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

  2. data suggest a physiological role for MNK1a-Ser (显示 SIGLEC1 ELISA试剂盒)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

  3. Results of our study suggest that the eIF4E/Fmr1 (显示 FMR1 ELISA试剂盒) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  4. Our findings identify the eIF4E- beta-catenin (显示 CTNNB1 ELISA试剂盒) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  5. Unphosphorylated HSP27 (显示 HSPB1 ELISA试剂盒) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  6. Rotenone induction of hydrogen peroxide inhibits mTOR (显示 FRAP1 ELISA试剂盒)-mediated S6K1 (显示 RPS6KB1 ELISA试剂盒) and 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒)/eIF4E pathways, resulting in caspase (显示 CASP3 ELISA试剂盒)-dependent and -independent apoptosis in neuronal cells.

  7. Findings indicate eIF4E is maintained at levels in excess for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.

  8. a light- and circadian clock-regulated MAPK (显示 MAPK1 ELISA试剂盒)/MNK (显示 ATP7A ELISA试剂盒) pathway led to phosphorylation of the cap-binding protein eIF4E

  9. mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and cells isolated from these mice exhibit impaired invasion.

  10. Data suggest that MAP kinase (显示 MAPK1 ELISA试剂盒)-interacting kinases (Mnk1 (显示 MKNK1 ELISA试剂盒), Mnk2 (显示 MKNK2 ELISA试剂盒)) regulate cell migration/wound healing, expression of vimentin (显示 VIM ELISA试剂盒), stability of vimentin (显示 VIM ELISA试剂盒) protein, and binding of eIF4E and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (显示 CYFIP1 ELISA试剂盒)).

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (显示 EIF4A2 ELISA试剂盒) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (显示 EIF4A2 ELISA试剂盒) and degradation of 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒) and/or truncation of 4E-BP2 (显示 EIF4EBP2 ELISA试剂盒) that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒) abundance and phosphorylation as well as different eIF4E/4E-BP1 (显示 EIF4EBP1 ELISA试剂盒) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E 抗原简介

Antigen Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E) 抗体
  • eucaryotic initiation factor6 (eif6) 抗体
  • eukaryotic translation initiation factor 4E (eif4e) 抗体
  • eIF-4E protein (eif4e) 抗体
  • eukaryotic translation initiation factor 4E (EIF4E) 抗体
  • eukaryotic translation initiation factor 4E (Eif4e) 抗体
  • eukaryotic translation initiation factor 4ea (eif4ea) 抗体
  • translation initiation factor eIF4E (LOC100533326) 抗体
  • 2 抗体
  • 0260/09 抗体
  • 0587/11 抗体
  • 0589/11 抗体
  • 0919/12 抗体
  • 1004/13 抗体
  • 7238 抗体
  • AUTS19 抗体
  • cbp 抗体
  • CG4035 抗体
  • CT13384 抗体
  • CT39424 抗体
  • CT39426 抗体
  • D-eIF4E 抗体
  • deIF-4E 抗体
  • deIF4E 抗体
  • Dmel\\CG4035 抗体
  • EG668879 抗体
  • EIF-4E 抗体
  • eIF-4E1 抗体
  • eIF-4E2 抗体
  • eIF-4EII 抗体
  • eif4e 抗体
  • eIF 4E 抗体
  • eif4e-1 抗体
  • eIF4E-1/2 抗体
  • eIF4E-2 抗体
  • Eif4e-ps 抗体
  • EIF4E1 抗体
  • eIF4EI 抗体
  • EIF4EL1 抗体
  • EIF4F 抗体
  • If4e 抗体
  • l(3)07238 抗体
  • l(3)67Af 抗体
  • l(3)S025007 抗体
  • l(3)S026009 抗体
  • l(3)S058711 抗体
  • l(3)S091912 抗体
  • zgc:86680 抗体

Protein level used designations for EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

GENE ID SPECIES
45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
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