Use your antibodies-online credentials, if available.
抗Human WNT5A 抗体:
抗Rat (Rattus) WNT5A 抗体:
抗Mouse (Murine) WNT5A 抗体:
Cow (Bovine) Polyclonal WNT5A Primary Antibody for IHC, IHC (p) - ABIN4366188
Rao, Liu, Zhou, Ma, Lu, Zhou: Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. in Tumori 2010
Show all 9 Pubmed References
Human Monoclonal WNT5A Primary Antibody for ICC, IHC - ABIN969460
Dai, Hall, Escara-Wilke, Mizokami, Keller, Keller: Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. in Cancer research 2008
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for IHC, ELISA - ABIN969461
Ford, Ekström, Andersson: Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 2 Pubmed References
Dog (Canine) Polyclonal WNT5A Primary Antibody for IF (p), IHC (p) - ABIN675758
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. in PLoS ONE 2014
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for IF, IHC - ABIN967259
Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. in The Journal of biological chemistry 2009
Show all 3 Pubmed References
Dog (Canine) Polyclonal WNT5A Primary Antibody for IHC (p), WB - ABIN675760
Saha, Aranda, Hayakawa, Bhanja, Atay, Brodin, Li, Asfaha, Liu, Tailor, Zhang, Godwin, Tome, Wang, Guha, Pollard: Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury. in Nature communications 2016
Human Monoclonal WNT5A Primary Antibody for IHC (p), ELISA - ABIN521385
Thiele, Göbel, Rachner, Fuessel, Froehner, Muders, Baretton, Bernhardt, Jakob, Glüer, Bornhäuser, Rauner, Hofbauer: WNT5A has anti-prostate cancer effects in vitro and reduces tumor growth in the skeleton in vivo. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015
Human Monoclonal WNT5A Primary Antibody for ELISA, ICC - ABIN2869402
Chang, Nam, Kook, Kim, Liu, Yao, Jung, Lemos, Seo, Park, Gim, Hong, Huh, Kim, Tan, Liu, Powis, Park, Liang, Kim: HNF4? is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. in Gut 2014
Show all 3 Pubmed References
Human Polyclonal WNT5A Primary Antibody for FACS, IHC (p) - ABIN651869
He, Saint-Jeannet, Wang, Nathans, Dawid, Varmus: A member of the Frizzled protein family mediating axis induction by Wnt-5A. in Science (New York, N.Y.) 1997
Show all 5 Pubmed References
Human Monoclonal WNT5A Primary Antibody for ELISA, IHC - ABIN4366183
Prgomet, Andersson, Lindberg: Optimization, validation, and identification of two reliable antibodies for immunodetection of WNT5A. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2017
Annotation of rs11918967 in WNT5A in tissues might be related to obesity.
Wnt5a expression is critical for proliferation of RL and VZ progenitors and Purkinje cell dendritogenesis during early embryonic development resulting in retarded development of cerebellum during postnatal stages.
Study shows that Wnt5a is upregulated in invasive glioblastoma tissues, and demonstrates that it may regulate the invasion of glioblastoma cells, at least in part via the Daam1 (显示 DAAM1 抗体)/RhoA (显示 RHOA 抗体) signaling pathway.
The findings suggest that Wnt5a expression may be involved in the inhibition of cell differentiation and the induction of an inflammatory response.
High WNT5A expression is associated with gliomas
Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer, which is involved in the activation of beta-catenin (显示 CTNNB1 抗体)-dependent canonical Wnt (显示 WNT2 抗体) signaling.
This study suggests that methylation of Wnt (显示 WNT2 抗体) pathway genes, in addition to known CpG island methylator phenotype markers, may help predict treatment outcome and survival in patients with CRC (显示 CALR 抗体)[colorectal cancer.
non-canonical Wnt5a signalling could play a role in early human trophoblast development by promoting cell proliferation and survival.
These findings suggest that WNT-5A modulates fundamental mechanisms that affect airway smooth muscle contraction and thus may be of relevance for airway hyperresponsiveness in asthma.
We performed immunohistochemistry for Ki67 (显示 MKI67 抗体), p16INK4a, and WNT5A in human HPs (显示 HPS1 抗体) ( hyperplastic polyps), sessile serrated adenomas/polyps (SSA (显示 TRIM21 抗体)/Ps), and traditional serrated adenomas (TSAs) .The distribution of Ki67 (显示 MKI67 抗体) and p16INK4a positive cells in TSAs was different from that in HPs (显示 HPS1 抗体) and SSA (显示 TRIM21 抗体)/Ps.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (显示 WNT3A 抗体), acted across many cell diameters to orient Prickle3 (显示 PRICKLE3 抗体)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (显示 ROR2 抗体), which require Wnt5a/Ror2 (显示 ROR2 抗体) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (显示 PCDH8 抗体) signaling via RhoA (显示 RHOA 抗体) and Wnt5a/Ror2 (显示 ROR2 抗体) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (显示 RSPO3 抗体) binds syndecan 4 and that together they activate Wnt5a/PCP (显示 PRCP 抗体) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (显示 SDC4 抗体) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (显示 PCDH8 抗体) by XWnt-5A requires the receptor tyrosine kinase Ror2 (显示 ROR2 抗体).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (显示 WNT2 抗体)/JNK (显示 MAPK8 抗体) signaling
WNT5A is a negative regulator of FSH (显示 BRD2 抗体)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Activating effect of WNT5A regulated bone formation in response to hindlimb unloading in mice, and pretreatment with WNT5A partly rescued the osteoporosis caused by mechanical unloading.
The results of this study indicated that Shh (显示 SHH 抗体), Sfrp1 (显示 SFRP1 抗体), and Wnt5a collaborate to direct the pathfinding of descending 5-HT (显示 DDC 抗体) axons in the brainstem.
calcineurin is a key regulator of Wnt5a-induced AQP2 (显示 AQP2 抗体) activation without affecting intracellular cAMP level and PKA activity.
The findings demonstrate that induction of Vangl protein phosphorylation plays an essential role in transducing Wnt5a signaling to establish Planar cell polarity (PCP (显示 BMP1 抗体)) in mammalian development, suggesting a phosphorylation-regulated (显示 PHAX 抗体) "Vangl activity gradient" model in addition to the well-documented "Fz activity gradient" model in Wnt (显示 WNT2 抗体)/PCP (显示 BMP1 抗体) signaling.
Post-mitotic filopodial "pathfinding" is guided by mesenchymal WNT5A. Without WNT5A, some cells fail to tether basally and undergo apoptosis, leading to a shortened midgut.
We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP (显示 BMP1 抗体)) in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf4 (显示 FGF4 抗体) and Fgf8 (显示 FGF8 抗体) signaling to orient PCP (显示 BMP1 抗体).
Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.
These data suggest that Wnt5a modulates the development of arthritis by promoting inflammation and osteoclast fusion, and provide the first mouse genetic evidence of a role for endogenous Wnt5a in autoimmune disease.
Here, we show that deletion of a single Wnt (显示 WNT2 抗体) family member, Wnt5a, is sufficient to elicit profound disruptions in synaptic plasticity, structural maintenance, and learning and memory in adult mice, identifying the importance of this particular noncanonical Wnt (显示 WNT2 抗体) in later-life functions.
Wnt5a promotes IL-6 (显示 IL6 抗体) and TIMP-1 (显示 TIMP1 抗体) release from mouse cardiac fibroblasts.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5