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抗Human TCF4 抗体:
抗Mouse (Murine) TCF4 抗体:
抗Rat (Rattus) TCF4 抗体:
Human Monoclonal TCF4 Primary Antibody for IF, ELISA - ABIN520754
Tanaka, Itoh, Nishiyama, Takezawa, Kurihara, Itoh, Kato: Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. in Blood 2010
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Human Monoclonal TCF4 Primary Antibody for IHC (p), IP - ABIN264393
Barker, Huls, Korinek, Clevers: Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium. in The American journal of pathology 1999
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Human Monoclonal TCF4 Primary Antibody for EMSA, IHC (p) - ABIN264394
Denys, Jadidizadeh, Amini Nik, Van Dam, Aerts, Alman, Cassiman, Tejpar: Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. in Oncogene 2004
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Human Monoclonal TCF4 Primary Antibody for IF, WB - ABIN393964
Eichhoff, Weeraratna, Zipser, Denat, Widmer, Xu, Kriegl, Kirchner, Larue, Dummer, Hoek: Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching. in Pigment cell & melanoma research 2011
Human Polyclonal TCF4 Primary Antibody for IHC, IHC (p) - ABIN4358095
Saegusa, Hashimura, Kuwata: Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas. in Laboratory investigation; a journal of technical methods and pathology 2012
Human Polyclonal TCF4 Primary Antibody for IF, IP - ABIN2476691
Valenta, Lukas, Doubravska, Fafilek, Korinek: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. in The EMBO journal 2006
FOXN3 (显示 FOXN3 抗体) bind to beta-catenin (显示 CTNNB1 抗体) and inhibited beta-catenin (显示 CTNNB1 抗体)/TCF (显示 HNF4A 抗体) signaling by blocking the interaction between beta-catenin (显示 CTNNB1 抗体) and TCF4. Loss of FOXN3 (显示 FOXN3 抗体) in colon cancer activates beta-catenin (显示 CTNNB1 抗体)/TCF (显示 HNF4A 抗体) signaling and promotes the growth and migration of cancer cells.
Expression of TCF4 in a neural progenitor cell line derived from the developing human cerebral cortex was reduced using RNA interference. Genes that were differentially expressed following TCF4 knockdown were highly enriched for involvement in the cell cycle. There was a nonsignificant trend for genetic association between the differentially expressed gene set and schizophrenia.
TCF4 knockdown promoted HepG-2 cell differentiation and inhibited tumor formation, and TCF4 could be the potential downstream target for clopidogrel therapy
A frameshift-causing partial TCF4 gene deletion was identified in an adult patient with mild ID and nonspecific facial dysmorphisms but without the typical features of Pitt-Hopkins syndrome. A nonsense variant within exon 8 was identified in a child presenting with a severe phenotype largely mimicking PTHS.
rs613872, rs17595731, and CTG repeat expansions in intronic region of TCF4 are associated with increased risk of sporadic late-onset FECD (显示 COL8a2 抗体) in the Indian cohort studied
High TCF4 expression is associated with colorectal cancer.
Examination of X-ray structures of the closely related TCF3 (显示 TCF3 抗体) and USF1 (显示 USF1 抗体) bound to DNA suggests TCF3 (显示 TCF3 抗体) can undergo a conformational shift to preferentially bind to 5hmC while the USF1 (显示 USF1 抗体) basic region is bulkier and rigid precluding a conformation shift to bind 5hmC. These results greatly expand the regulatory DNA sequence landscape bound by TCF4.
Array-comparative genomic hybridization confirmed a de novo paternal deletion of the 15q11.2q13 region and exome sequencing identified a second mutational event in both girls, which was a novel variant c.145+1G>A affecting a TCF4 canonical splicing site inherited from the mosaic mother
The CTG18.1 repeat expansion may reduce gene expression of TCF4 and ZEB1 (显示 ZEB1 抗体), suggesting that a mechanism triggering a loss of function may contribute to FECD (显示 COL8a2 抗体).
repeat expansion showed stronger association than the most significantly associated SNP, rs613872, in TCF4, with the disease in the Australian cohort
Our findings indicate that H2O2 inhibits NaV1.5 (显示 SCN5A 抗体) expression by activating the Wnt/b-catenin signaling and beta-catenin (显示 CTNNB1 抗体) interacts with TCF4 to transcriptionally suppress cardiac NaV1.5 (显示 SCN5A 抗体) expression.
Hdac2 (显示 HDAC2 抗体) isoform-selective knockdown was sufficient to rescue memory deficits in Tcf4(+/-) mice.
We report that TCF4 comprises two transcriptional isoforms, both of which are required for optimal plasmacytoid DC development in vitro
these data identified E2A (显示 TCF3 抗体) and E2-2 as central regulators of B cell immunity.
down-regulation of Id3 (显示 ID3 抗体) in B cells is essential for releasing E2A (显示 TCF3 抗体) and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation.
TCF-4 as a co-activator of p65 (显示 NFkBP65 抗体) in the potentiation of proinflammatory cytokine production in macrophages and aggravation of high-fat diet induced chronic inflammation and insulin (显示 INS 抗体) resistance in mice.
Data indicate that upregulation of E2-2 protein markedly attenuated the inhibitor of DNA-binding 1 (ID1 (显示 ID1 抗体))-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.
We conclude that E2-2 inhibited EPC (显示 TCF21 抗体) proliferation via suppressing their autophagy, and E2-2 regulated EPC (显示 TCF21 抗体) autophagy by mediating the expression of ATG7 (显示 ATG7 抗体).
demonstrated that Id1 (显示 ID1 抗体) and E2-2 are critical regulators of EPCs function in vitro. Id1 (显示 ID1 抗体) interacts with E2-2 and relieves the E2-2-mediated repression of FGFR1 (显示 FGFR1 抗体) and VEGFR2 (显示 KDR 抗体) expression to modulate EPCs functions
TCF4 is a regulator of neuronal intrinsic excitability in part by repression of Kcnq1 (显示 KCNQ1 抗体) and Scn10a (显示 SCN10A 抗体).
GRG5/AES (显示 AES 抗体) interacts with TCF4 (显示 TCF7L2 抗体) and represses Wnt (显示 WNT2 抗体)-mediated transcription both in human cells and zebrafish embryos.
Data indicte that Tcf-1 (显示 HNF1A 抗体) and Lef-1 (显示 LEF1 抗体) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (显示 TCF3 抗体) and -4.
Tcf4 (显示 TCF7L2 抗体) transcription factor cooperates in patterning the Xenopus brain.
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described.
SL3-3 enhancer factor 2
, class B basic helix-loop-helix protein 19
, immunoglobulin transcription factor 2
, Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2)
, class A helix-loop-helix transcription factor ME2
, immunoglobulin transcription factor-2
, R8f DNA-binding protein
, thyroglobulin promoter transcription factor TFE
, transcription factor 7-like 2 (T-cell specific, HMG-box)
, transcriptional factor 4
, helix-loop-helix transcription factor
, transcription factor 7-like 2
, transcription factor Tcf4
, LOW QUALITY PROTEIN: transcription factor 4