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Human SFRP4 Protein expressed in Wheat germ - ABIN1319736
Jacob, Ukegjini, Nixdorf, Ford, Olivier, Caduff, Scurry, Guertler, Hornung, Mueller, Fink, Hacker, Heinzelmann-Schwarz: Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. in PLoS ONE 2012
Mouse (Murine) SFRP4 Protein expressed in Human Cells - ABIN2007238
Jones, Jomary: Secreted Frizzled-related proteins: searching for relationships and patterns. in BioEssays : news and reviews in molecular, cellular and developmental biology 2002
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Both DKK2 and sFRP4 polymorphisms are found to play a crucial role; especially for smokers towards modulating risk for lung cancer.
Results show that SFRP2 and SFRP4 typically associate with a poor prognosis of cancer patients concomitant with the expression of genes associated with epithelial-to-mesenchymal transition. SFRP2 and 4 are likely derived from the tumor stroma, and thus tend to increase in tumors as compared to normal tissues.
Data suggest that factors derived from conditioned medium of adipose-derived mesenchymal stem cells and sFRP4 significantly decrease cell viability and cell migration of breast tumor cells; this is accompanied by enhanced apoptosis via inhibition of canonical Wnt signal transduction.
increased SFRP4 and ficolin-3 levels are significantly associated with gestational diabetes mellitus development and might be important risk factors for this pregnancy complication.
High SFRP4 expression is associated with mesothelioma.
Epicardial adipose tissue and circulating SFRP4 expression levels were increased with patients with coronary artery disease.
Serum SFRP-4 levels were significantly higher in the type 2 diabetes group compared to the impaired glucose tolerance and normal glucose tolerance groups.
Studied role of Secreted Frizzled-Related Protein 4 (sFRP4) in angiostasis thru nitric oxide-cGMP cell signaling.
Progesterone regulated SFRP4 gene expression plays a role in uterine leiomyoma.
SFRP4 expression is significantly upregulated in human masticatory mucosa during wound healing
SFRP4 is significantly increased in patients with different types of diabetes.
Weak sFRP4 expression appeared to predict aggressive behavior, and was associated with recurrence/progression of GH-secreting pituitary adenomas.
A decreased risk of lung cancer was found for the genotype combination of DKK3 and sFRP4.
Down-regulation of SFRP4 is associated with recurrence in Endometrioid Adenocarcinoma.
proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R inhibitors
concentrations of serum SFRP4 in T2DM and impaired glucose tolerance subjects were increased and were correlated closely with glycose metabolic disorder, the first-phase of glucose-stimulated insulin secretion and chronic low-grade inflammation
sFRP4 expression is inversely related to the aggressiveness of pituitary adenomas, and acts as a tumor suppressor.
Wnt3a can modulate intracellular localisation and secretion of sFRP4.
We found that miR-203 was significantly downregulated in OSF tissues compared to that in normal buccal mucosa tissues, and that miR-203 negatively regulated secreted SFRP4 and positively regulated TM4SF1
Serum WISP2 correlated directly with fatty acid binding protein 4. Serum SFRP5 did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (p<5x10(-6) as compared to both PCOS groups).
Upregulation of Wnt antagonist SFRP4 and adipogenic gene expression following castration, contributes to increased intramuscular fat deposition in the longissimus dorsi muscle.
SFRP4 expression levels were gradually increased and proportionally associated with epididymal white adipose tissue adipocyte differentiation toward maturation at 14 days, while inguinal white adipose tissue adipocyte just showed an opposite tendency.
Results indicate that sFRP4 plays a critical role in bone development and remodeling by regulating osteoblasts and osteoclasts, and that its functional loss prevents age-related bone loss in the trabecular bone. These findings imply that it functions as a potential balancer of the Wnt signaling pathway by direct influencing bone formation and absorption during skeletal bone development and maintenance through remodeling.
the cross-talk between SFRP4, integrin alpha1beta1, and Notch1 suppresses the cardiac differentiation of P19CL6 cells.
Our study showed that Pyle's disease was caused by a deficiency of sFRP4 and that sFRP4-mediated cross-regulation between Wnt and BMP signaling was critical for achieving proper cortical-bone thickness and stability.
MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 and Sfrp5.
In diet-induced obesity, loss of SFRP4 alters body length and bone mineral density as well as energy expenditure and food intake. However, SFRP4 does not control glucose homeostasis and beta-cell mass in mice.
MG-derived oxidative stress (not CpG demethylation) epigenetically and rapidly derepress sFRP-4 gene expression.
findings suggest that an epigenetic event is critically involved in the pathogenesis of psoriasis, and the downregulation of SFRP4 by CpG island methylation is one possible mechanism contributing to the hyperplasia of epidermis in the disease
extra-follicular modulators Bmp2, Dkk1, and Sfrp4 increase in early anagen.
studies indicate that mutations neither in sFRP1 nor in sFRP4 are a common cause of craniotubular hyperostoses
Data suggest that Sfrp4 does not contribute to the long-term regulation of serum phosphate levels in mice.
sFRP4 negatively regulates bone formation without disrupting phosphorus homeostasis.
the first promoter analysis of mouse Frp genes providing the basis for understanding the functions and the regulation of Frp and its role in regulating Wnt signals
beta-catenin signaling is activated in tubular epithelial and interstitial cells after renal injury, and recombinant sFRP4 interferes with epithelial de-differentiation and fibroblast differentiation and function during progression of renal fibrosis
Sfrp4 negatively regulates bone formation and decreases BMD through the inhibition of Wnt signaling
These results provide the first measurement of binding affinity of sFRPs for a Wnt, which together with the measurement of antagonistic activity of sFRPs could help understand how sFRPs regulate Wnt signaling.
These results indicate that Sfrp4 decreases bone formation at least in part by attenuating canonical Wnt signaling in vivo.
SFRP4 may modulate Wnt functions in Tsk skin fibrosis.
In conclusion, we found that different repertoires of sFRPs exert differential effects on osteoblastic differentiation of mouse mesenchymal cells and cellular apoptosis of mouse osteoblasts in vitro.
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
secreted frizzled-related protein 4
, secreted frizzled-related protein 4-like
, frizzled protein, human endometrium
, secreted frizzled-related protein 4; secreted frizzled-related protein 4
, secreted frizzled-relatedprotein 4
, frizzled-related protein 4
, secreted frizzled-related sequence protein 4
, DDC-4 protein
, frizzled related protein
, frizzled-related protein