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Human SFRP4 Protein expressed in Wheat germ - ABIN1319736
Jacob, Ukegjini, Nixdorf, Ford, Olivier, Caduff, Scurry, Guertler, Hornung, Mueller, Fink, Hacker, Heinzelmann-Schwarz: Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. in PLoS ONE 2012
Mouse (Murine) SFRP4 Protein expressed in Human Cells - ABIN2007238
Jones, Jomary: Secreted Frizzled-related proteins: searching for relationships and patterns. in BioEssays : news and reviews in molecular, cellular and developmental biology 2002
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Results show that SFRP2 (显示 SFRP2 蛋白) and SFRP4 typically associate with a poor prognosis of cancer patients concomitant with the expression of genes associated with epithelial-to-mesenchymal transition. SFRP2 (显示 SFRP2 蛋白) and 4 are likely derived from the tumor stroma, and thus tend to increase in tumors as compared to normal tissues.
Data suggest that factors derived from conditioned medium of adipose-derived mesenchymal stem cells and sFRP4 significantly decrease cell viability and cell migration of breast tumor cells; this is accompanied by enhanced apoptosis via inhibition of canonical Wnt (显示 WNT2 蛋白) signal transduction.
increased SFRP4 and ficolin-3 (显示 FCN3 蛋白) levels are significantly associated with gestational diabetes mellitus development and might be important risk factors for this pregnancy complication.
High SFRP4 expression is associated with mesothelioma.
Epicardial adipose tissue and circulating SFRP4 expression levels were increased with patients with coronary artery disease.
Serum SFRP-4 levels were significantly higher in the type 2 diabetes group compared to the impaired glucose tolerance and normal glucose tolerance groups.
Studied role of Secreted Frizzled-Related Protein 4 (sFRP4) in angiostasis thru nitric oxide-cGMP cell signaling.
Progesterone regulated SFRP4 gene expression plays a role in uterine leiomyoma.
SFRP4 expression is significantly upregulated in human masticatory mucosa during wound healing
SFRP4 is significantly increased in patients with different types of diabetes.
Upregulation of Wnt (显示 WNT2 蛋白) antagonist SFRP4 and adipogenic gene expression following castration, contributes to increased intramuscular fat deposition in the longissimus dorsi muscle.
SFRP4 expression levels were gradually increased and proportionally associated with epididymal white adipose tissue adipocyte differentiation toward maturation at 14 days, while inguinal white adipose tissue adipocyte just showed an opposite tendency.
Results indicate that sFRP4 plays a critical role in bone development and remodeling by regulating osteoblasts and osteoclasts, and that its functional loss prevents age-related bone loss in the trabecular bone. These findings imply that it functions as a potential balancer of the Wnt (显示 WNT2 蛋白) signaling pathway by direct influencing bone formation and absorption during skeletal bone development and maintenance through remodeling.
the cross-talk between SFRP4, integrin alpha1beta1, and Notch1 (显示 NOTCH1 蛋白) suppresses the cardiac differentiation of P19CL6 cells.
Our study showed that Pyle's disease was caused by a deficiency of sFRP4 and that sFRP4-mediated cross-regulation between Wnt and BMP signaling was critical for achieving proper cortical-bone thickness and stability.
MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 and Sfrp5 (显示 SFRP5 蛋白).
In diet-induced obesity, loss of SFRP4 alters body length and bone mineral density as well as energy expenditure and food intake. However, SFRP4 does not control glucose homeostasis and beta-cell mass in mice.
MG-derived oxidative stress (not CpG demethylation) epigenetically and rapidly derepress sFRP-4 gene expression.
findings suggest that an epigenetic event is critically involved in the pathogenesis of psoriasis, and the downregulation of SFRP4 by CpG island methylation is one possible mechanism contributing to the hyperplasia of epidermis in the disease
extra-follicular modulators Bmp2 (显示 BMP2 蛋白), Dkk1 (显示 DKK1 蛋白), and Sfrp4 increase in early anagen.
studies indicate that mutations neither in sFRP1 (显示 SFRP1 蛋白) nor in sFRP4 are a common cause of craniotubular hyperostoses
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
secreted frizzled-related protein 4
, secreted frizzled-related protein 4-like
, frizzled protein, human endometrium
, secreted frizzled-related protein 4; secreted frizzled-related protein 4
, secreted frizzled-relatedprotein 4
, frizzled-related protein 4
, secreted frizzled-related sequence protein 4
, DDC-4 protein
, frizzled related protein
, frizzled-related protein