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抗Human DVL1 抗体:
抗Mouse (Murine) DVL1 抗体:
抗Rat (Rattus) DVL1 抗体:
Human Polyclonal DVL1 Primary Antibody for IF (p), IHC (p) - ABIN670671
Hua, Xu, He, Jiang, Ye, Pan: Wnt4/?-catenin signaling pathway modulates balloon-injured carotid artery restenosis via disheveled-1. in International journal of clinical and experimental pathology 2015
Human Polyclonal DVL1 Primary Antibody for IF, IHC (p) - ABIN656260
Varelas, Miller, Sopko, Song, Gregorieff, Fellouse, Sakuma, Pawson, Hunziker, McNeill, Wrana, Attisano: The Hippo pathway regulates Wnt/beta-catenin signaling. in Developmental cell 2010
Show all 2 Pubmed References
Pig (Porcine) Polyclonal DVL1 Primary Antibody for ELISA, WB - ABIN1782135
Spate, Brown, Redel, Whitworth, Murphy, Prather: Dickkopf-related protein 1 inhibits the WNT signaling pathway and improves pig oocyte maturation. in PLoS ONE 2014
Human Polyclonal DVL1 Primary Antibody for IHC (p), WB - ABIN4268104
Jung, Lee, Kim, Dhong, Cho, Roh: Role of Wnt signaling pathway in progression of sinonasal inverted papilloma to squamous cell carcinoma. in American journal of rhinology & allergy 2015
Human Polyclonal DVL1 Primary Antibody for ELISA, WB - ABIN560673
Turashvili, Bouchal, Baumforth, Wei, Dziechciarkova, Ehrmann, Klein, Fridman, Skarda, Srovnal, Hajduch, Murray, Kolar: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. in BMC cancer 2007
Lack of DVL (显示 DVL2 抗体) prevents NEK2 (显示 NEK2 抗体)-controlled dissolution of loose centrosomal linker and subsequent centrosomal separation. Increased DVL (显示 DVL2 抗体) levels, in contrast, sequester centrosomal NEK2 (显示 NEK2 抗体) and mimic monopolar spindle defects induced by a dominant negative version of this kinase.
These results identify USP4 (显示 USP4 抗体) as a novel regulator of Dvl (显示 DVL2 抗体) in Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signal and show its involvement in Wnt3a (显示 WNT3A 抗体)-induced osteoblast differentiation
Authors conclude that the planar cell polarity (PCP (显示 PRCP 抗体)) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 (显示 RNF41 抗体) acts as a negative regulator of PCP (显示 PRCP 抗体) signaling by inhibiting Dvl (显示 DVL2 抗体) through a novel polyubiquitination mechanism.
The DEP (显示 ZDHHC21 抗体) domain of Dishevelled (显示 DVL2 抗体) undergoes a conformational switch, from monomeric to swapped dimer, to trigger DIX domain-dependent polymerization and signaling to beta-catenin (显示 CTNNB1 抗体).
two mutually exclusive functions of the DEP (显示 ZDHHC21 抗体) domain in Wnt (显示 WNT2 抗体) signal transduction - binding to Frizzled to recruit Dishevelled (显示 DVL2 抗体) to the receptor complex, is reported.
we show that Wnt5a (显示 WNT5A 抗体) rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (显示 POLR1C 抗体) (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.
Data show that dishevelled (显示 DVL2 抗体) proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (显示 SFRP2 抗体) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
Data show that receptor for activated C kinase 1 (RACK1 (显示 GNB2L1 抗体)) interacts with Dishevelled (Dvl (显示 DVL2 抗体)) proteins and promotes their lysosomal degradation, and this effect is enhanced by autophagy induction.
TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl.
Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain (显示 INADL 抗体) is stabilized upon CXXC finger 5 protein (CXXC5 (显示 CXXC5 抗体)) binding.
Here we show that the peptide-binding pocket of the Dvl PDZ domain (显示 INADL 抗体) can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation.
The interaction of Dvl1 with Syt-1 (显示 SYT1 抗体), which is regulated by Wnts, modulates neurotransmitter release.
findings indicate that Dvl-1 may be an underlying participant of oxidative stress induced (显示 SQSTM1 抗体) by selenium deficiency
These results support a novel cell-autonomous postsynaptic role for Dact1 (显示 DACT1 抗体), in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1 (显示 DISC1 抗体), in the formation of synapses on cortical interneuron dendrites.
we show that Dvl-1 expression is restricted to OSNs in the dorsal recess of the nasal cavity, and labels a unique subpopulation of glomeruli. Dvl-2 (显示 DVL2 抗体) and Dvl-3 (显示 DVL3 抗体) have a widespread distribution in both the olfactory epithelium and olfactory bulb .
Fuzzy appears to control subcellular localization of the core PCP (显示 BMP1 抗体) protein Dishevelled (显示 DVL2 抗体), recruiting it to Rab8 (显示 RAB8A 抗体)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (显示 BMP1 抗体) signaling
A Wnt5a (显示 WNT5A 抗体)--> Dvl PCP (显示 BMP1 抗体) signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal (显示 CAD 抗体) splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.
Findings indicate that Daple (显示 CCDC88C 抗体) interacts with Dishevelled (显示 DVL2 抗体) to direct the Dishevelled (显示 DVL2 抗体)/protein kinase (显示 CDK7 抗体) lambda protein complex to activate Rac (显示 AKT1 抗体), which in turn mediates the non-canonical Wnt (显示 WNT2 抗体) signalling pathway required for cell migration.
The antagonistic functions of Vangl2 (显示 VANGL2 抗体) and Dvl1 allow sharpening of planar cell polarity signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones.
Different Dvl (显示 DVL2 抗体) proteins (Dvl1, Dvl2 (显示 DVL2 抗体), Dvl3 (显示 DVL3 抗体)) and the composition of dishevelled (显示 DVL2 抗体)-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (显示 WNT2 抗体) signaling in Xenopus gastrulation.
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
DSH homolog 1
, dishevelled 1 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 1
, segment polarity protein dishevelled homolog DVL-1
, dishevelled 1
, dishevelled, dsh homolog 2, like