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抗Human AES 抗体:
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Human Polyclonal AES Primary Antibody for ICC, ELISA - ABIN1001757
Martin, Vuori: Regulation of Bcl-2 proteins during anoikis and amorphosis. in Biochimica et biophysica acta 2004
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Human Polyclonal AES Primary Antibody for ICC, ELISA - ABIN1001758
Miyasaka, Choudhury, Hou, Li: Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. in European journal of biochemistry / FEBS 1993
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Human Polyclonal AES Primary Antibody for IHC (fro), WB - ABIN2477291
Link, Henneberg, Hövener: [Control of respirator pressure and drainage of the anesthetic gases with Kuhn's device in pediatric anesthesia (author's transl)]. in Der Anaesthesist 1976
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Results suggest that amino enhancer of split protein (AES) plays an important role in controlling tumor growth and metastasis of prostate cancer (PCa (显示 FLVCR1 抗体)) by regulating both androgen receptor (AR (显示 AR 抗体)) and Notch (显示 NOTCH1 抗体) signaling pathway.
results indicate that Aes may belong to a novel family of metastasis su (显示 YY2 抗体)ppressors with a CpG-island promoter enhancer, and it is regulated transcriptionally
heat shock cognate 70 (HSC70 (显示 HSPA8 抗体)) is an essential component of Aes foci in colorectal cancer cells.
AES is a transcriptional repressor for HNF-1-alpha (显示 HNF1A 抗体) in pancreatic beta-cell.
AES binds to PROP1 (显示 PROP1 抗体) and represses its expression; PROP1 (显示 PROP1 抗体) mutation is a likely cause of combined pituitary hormone (显示 CGA 抗体) deficiency.
GRG5/AES interacts with TCF4 (显示 TCF4 抗体) and represses Wnt (显示 WNT2 抗体)-mediated transcription both in human cells and zebrafish embryos.
alteration of the malignant behavior of cancer cells by AES is related to RND3 (显示 RND3 抗体) regulation.
In the presence of NUP98 (显示 NUP98 抗体)-HOXA9 (显示 HOXA9 抗体), AES caused an increase in long-term proliferation of primary human CD34 (显示 CD34 抗体)+ cells with a marked increase in the numbers of primitive cells.
Elevated levels of AES mRNA (显示 RUNX1 抗体)and (显示 RUNX1T1 抗体)protein were confirmed in AML1/ETO-expressing leukemia cells, as well as in other acute myeloid leukemia specimens.
LRP6 (显示 LRP6 抗体)-ICD (显示 GNPTAB 抗体) interacts with AES exclusively in the nucleus and represses AES mediated TCF (显示 HNF4A 抗体)/LEF-1 (显示 LEF1 抗体) reporter transcription.
in a transplantation mouse model of liver metastases, expression of Yy2 (显示 YY2 抗体) (and therefore of Aes) is downregulated
The finding that Foxh1 (显示 FOXH1 抗体)-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions.
Self-renewal induced by AML1 (显示 RUNX1 抗体)/ETO (显示 RUNX1T1 抗体) in primary murine progenitors was inhibited when Aes was decreased or absent.
The Aes gene functions as an endogenous metastasis suppressor. Aes inhibits Notch (显示 NOTCH1 抗体) signaling by converting active Rbpj (显示 RBPJ 抗体) transcription complexes into repression complexes on insoluble nuclear matrix.
Data suggest that Grg5 modulates the activities of transcription factors in vivo to affect Ihh (显示 IHH 抗体) expression and the function of long bone growth plates.
Tcf4 (显示 TCF4 抗体) and Aes influence pituitary growth and development, and place Tcf4 (显示 TCF4 抗体) and Tle3 in the genetic hierarchy with Prop1 (显示 PROP1 抗体)
Grg5 acts as a positive regulator of Runx2 (显示 RUNX2 抗体) activity and is necessary for full expression and signalling of Indian hedgehog (Ihh (显示 IHH 抗体)).
Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity.
direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothalamic neurons
GRG5/AES interacts with TCF4 (显示 TCF7L2 抗体) and represses Wnt (显示 WNT2 抗体)-mediated transcription both in human cells and zebrafish embryos.
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
gp130-associated protein GAM
, related to Drosophila groucho
, amino enhancer of split
, amino enhancer split
, amino-terminal enhancer of split
, transducin-like enhancer of split 4 homolog of Drosophila E(spl)