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抗Rat (Rattus) 抗体:
Human Polyclonal PFDN2 Primary Antibody for WB - ABIN1881647
Cloutier, Al-Khoury, Lavallée-Adam, Faubert, Jiang, Poitras, Bouchard, Forget, Blanchette, Coulombe: High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. in Methods (San Diego, Calif.) 2009
Show all 3 Pubmed References
Knocking down prefoldin-2 (Pfdn2) expression in primary murine retinal ganglion cells(RGCs) significantly reduced Sncg (显示 SNCG 抗体) expression, confirming that Pfdn2 regulates Sncg (显示 SNCG 抗体) expression in murine RGCs.
knockdown of PFD2 and PFD5 (显示 PFDN5 抗体) disrupted prefoldin formation in HTT (显示 HTT 抗体)-expressing cells, resulting in accumulation of aggregates of a pathogenic form of HTT (显示 HTT 抗体) and in induction of cell death.
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
prefoldin subunit 2
, prefoldin 2