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Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (显示 MST1 ELISA试剂盒)/2)/YAP (显示 YAP1 ELISA试剂盒) signaling, and that inhibition of miR (显示 MLXIP ELISA试剂盒)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (显示 SOX2 ELISA试剂盒) and SALL4 (显示 SALL4 ELISA试剂盒).
These findings reveal a novel layer of regulation for MST2 in mitosis and its role in tumorigenesis.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1 (显示 MST1 ELISA试剂盒)/2 protein kinases) - Yes associated protein 1 (YAP (显示 YAP1 ELISA试剂盒)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
H-ras (显示 HRAS ELISA试剂盒), via an Erk (显示 EPHB2 ELISA试剂盒)-dependent mechanism, downregulates Mst1 (显示 MST1 ELISA试剂盒)/Mst2 activity by inducing the formation of inactive Mst1 (显示 MST1 ELISA试剂盒)/Mst2 heterodimers.
Results show that STK3 is targeted by Casp6 (显示 CASP6 ELISA试剂盒) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (显示 CASP3 ELISA试剂盒)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.
using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (显示 SAV1 ELISA试剂盒) refolded under acidic pH.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
These results suggest that AIF (显示 AIFM1 ELISA试剂盒) downregulation is a common event in kidney tumor development. AIF (显示 AIFM1 ELISA试剂盒) loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation
Hippo and Yap (显示 YAP1 ELISA试剂盒) regulate cardiomyocyte death and regeneration.
It is involved in apoptosis and serine/threonine kinase 3 (STK3 (显示 PKN1 ELISA试剂盒)) is a recently identified caspase-6 (显示 CASP6 ELISA试剂盒) substrate.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (显示 MST1 ELISA试剂盒) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (显示 YAP1 ELISA试剂盒) target genes and hepatocyte proliferation.
Studies indicate that Hippo (Hpo (显示 GFER ELISA试剂盒); MST1 (显示 MST1 ELISA试剂盒)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway
the TLR-Mst1 (显示 MST1 ELISA试剂盒)-Mst2-Rac (显示 AKT1 ELISA试剂盒) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (显示 STK4 ELISA试剂盒) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (显示 MAP1LC3A ELISA试剂盒) by the STK3 (显示 PKN1 ELISA试剂盒) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (显示 MST1 ELISA试剂盒), as a critical regulator of caspase (显示 CASP3 ELISA试剂盒)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
Mst1 (显示 MST1 ELISA试剂盒)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (显示 MST1 ELISA试剂盒)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)