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Although napsin A is infrequently expressed in endometrial carcinomas, positive results of napsin A immunostaining in endometrial neoplasms might support the diagnosis of clear cell carcinoma when the pathologic differential diagnosis includes other histologic subtypes
Immunohistochemical detection of thyroid transcription factor 1 (显示 NKX2-1 蛋白), Napsin A, and P40 (显示 IL9 蛋白) fragment of TP63 (显示 TP63 蛋白) can be used in the subclassification of non-small cell lung carcinomas.
it may be useful to combine NAPA (显示 NAPA 蛋白) and TTF-1 (显示 NKX2-1 蛋白) for increased sensitivity in lung cancer diagnostics. There is no substantial difference between monoclonal and polyclonal p40 (显示 IL9 蛋白) and between different NAPA (显示 NAPA 蛋白) clones, whereas there is a difference between the TTF-1 (显示 NKX2-1 蛋白) clones 8G7G3/1 and SPT24
To the best of our knowledge, expression of monoclonal Napsin A in lymphomas has never been reported. ALK-DLBCL should be considered in the differential diagnosis when evaluating a Napsin A-positive tumor of poorly differentiated morphology and of unknown primary
It is important for pathologists to be aware that breast carcinomas with apocrine features can express napsin A.
High Napsin A expression is associated with adenocarcinoma in non-small cell lung carcinoma.
Napsin-A, and Desmocollin-3 (显示 DSC2 蛋白) were sensitive and specific markers for the diagnosis of AC and SCC (显示 CYP11A1 蛋白), respectively. Both markers allowed classification of 54/60 cases into either AC or SCC (显示 CYP11A1 蛋白).
napsin A is aberrantly expressed in a subset of lymphomas
CK7 (显示 KRT7 蛋白), TTF-1 (显示 NKX2-1 蛋白) and napsin A are predominantly expressed in primary lung adenocarcinoma patients, with CDX-2 (显示 CDX2 蛋白) being inconsistently expressed.
The immunocytochemical expressions of napsin A and p40 in imprint cytology seem to be of great utility for the accurate histological differentiation of lung cancers.
The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.
, asp 4
, aspartyl protease 4
, kidney-derived aspartic protease-like protein
, pronapsin A
, napsin 1
, napsin A aspartic peptidase L homeolog