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抗Human GRLF1 抗体:
抗Mouse (Murine) GRLF1 抗体:
抗Rat (Rattus) GRLF1 抗体:
Human Polyclonal GRLF1 Primary Antibody for IHC (p), IHC - ABIN408537
Eberwein, Laird, Schulz, Reinhard, Steinberg, Tomakidi: Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors. in Biochimica et biophysica acta 2015
Human Polyclonal GRLF1 Primary Antibody for IHC (p) - ABIN5579387
Li, Li, Zhou, Wang, Wang, Zhao, Cui, Ren, Dong, Chen: Abnormal expression of p190RhoGAP in colorectal cancer patients with poor survival. in American journal of translational research 2016
report association of APOE (显示 APOE 抗体) and TOMM40 (显示 TOMM40 抗体) with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 (显示 SERPINA1 抗体) with progressive non-fluent aphasia.
interaction involves the first FF motif of p190A and the winged helix/PCI (显示 SERPINA5 抗体) domain of eIF3A (显示 EIF6 抗体), is enhanced by serum stimulation and reduced by phosphatase treatment
these data demonstrate that a complex of p190RhoGAP-A and anillin (显示 ANLN 抗体) modulates RhoA (显示 RHOA 抗体)-GTP (显示 AK3 抗体) levels in the cytokinetic furrow to ensure progression of cytokinesis.
These results place Blk (显示 BLK 抗体) upstream of the p190RhoGAP-RhoA (显示 RHOA 抗体) pathway in Galpha13 (显示 GNA13 抗体)-activated cells, overall representing an opposing signaling module during CXCL12 (显示 CXCL12 抗体)-triggered invasion.
ARHGAP35 rs1052667 polymorphism was an independent prognostic factor influencing the survival of osteosarcoma.
GRF-1 expression may modify osteosarcoma prognosis and may be a potential tumor therapeutic target.
A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP (显示 RASA1 抗体)), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS.
Overexpression of p190 (显示 CNTNAP1 抗体) mRNA associated with lung adenocarcinoma.
These data suggest that the interaction of human papillomavirus E7 with p190 dysregulates this GTPase activating protein and alters the actin cytoskeleton.
RhoA (显示 RHOA 抗体) is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.
p190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation.
The cellular RacGAP activity of p190RhoGAP requires an intact polybasic region adjacent to the GAP domain whereas the RhoGAP (显示 ARHGAP1 抗体) activity is inhibited by the same domain.
study demonstrates that the epidermal growth factor receptor (EGFR (显示 EGFR 抗体)) cooperates with beta3 integrin (显示 ITGB3 抗体) to regulate p190RhoGAP activity in mammary gland epithelial cells
p190RhoGAP links integrins and caveolin-1 (显示 CAV1 抗体)/caveolae to RhoA (显示 RHOA 抗体) in a mechanotransduction cascade that participates in endothelial adaptation to flow.
In a novel knockout mouse strain p190RhoGAP does not play a major, indispensable role in integrin signaling of neutrophils.
Cdh1 (显示 CDH1 抗体) formed a physical complex with p190 (显示 CNTNAP1 抗体) and stimulated the efficient ubiquitination of p190 (显示 CNTNAP1 抗体), both in in vitro and in vivo.
identified the serum-responsive transcriptional regulator TFII-I (显示 GTF2I 抗体) as a specific interactor with the p190 RhoGAP FF domains
p190 transiently associates with plexins, and its RhoGAP activity is increased in response to semaphorin stimulation. We conclude that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins.
FAK (显示 PTK2 抗体)-induced down-modulation of RhoA (显示 RHOA 抗体) activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability
Rac (显示 AKT1 抗体) activation links diverse signaling systems to adherens junction assembly by controlling transient p190RhoGAP interactions with p120 (显示 CTNND1 抗体) and localized inhibition of Rho.
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
glucocorticoid receptor DNA binding factor 1
, glucocorticoid receptor DNA-binding factor 1
, glucocorticoid receptor repression factor 1
, rho GAP p190A
, rho GTPase-activating protein 35
, P190 RhoGAP
, GAP-associated protein p190
, Rho GTPase activating protein 35 L homeolog
, rho GTPase activating protein 35 L homeolog