Use your antibodies-online credentials, if available.
抗Rat (Rattus) DVL2 抗体:
抗Mouse (Murine) DVL2 抗体:
抗Human DVL2 抗体:
Cow (Bovine) Polyclonal DVL2 Primary Antibody for IHC, WB - ABIN2779458
Lee, Zhao, Moon, Yoon, Kim, An, Kwon, Hwang, Choi, Shim, Kim, Yang: Differential involvement of GABA system in mediating behavioral and neurochemical effect of acupuncture in ethanol-withdrawn rats. in Neuroscience letters 2008
Show all 2 Pubmed References
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (显示 ROR2 抗体), which influenced Ras Homology Family Member A (显示 CXCL14 抗体) (RhoA (显示 RHOA 抗体)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (显示 ROCK1 抗体)) activity downstream of Dishevelled-2 (Dvl2).
Epsins are required for Dishevelled stability and Wnt (显示 WNT2 抗体) signalling activation in colon cancer development.
Dpr1 (显示 DACT1 抗体) promotes the ubiquitination of Dvl2 by pVHL (显示 VHL 抗体) and mediates the protein aggregate-elicited autophagy initiation
Dvl2 binds to Rab35 (显示 RAB35 抗体) and activation is required for MCF-7 cell migration
Dvl-2 and Dvl-3 (显示 DVL3 抗体) have a widespread distribution in both the olfactory epithelium and olfactory bulb
Dullard may play a role in the fine-tuning of WNT (显示 WNT2 抗体) signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage.
loss of Dvl2 function in Vangl2(Lp (显示 VANGL2 抗体)/+) embryos did not exacerbate the Vangl2(Lp (显示 VANGL2 抗体)/+) neuronal migration phenotype
Identification of a novel Wnt5a (显示 WNT5A 抗体)-CK1varepsilon-Dvl2-Plk1 (显示 PLK1 抗体)-mediated primary cilia disassembly pathway.
These findings suggest that Wnt5a (显示 WNT5A 抗体)-Ror-Dishevelled signaling constitutes a core noncanonical Wnt (显示 WNT2 抗体) pathway that is conserved through evolution and is crucial during embryonic development.
Dvl2 has an inhibitory role in myogenesis and Stau1 (显示 STAU1 抗体) coordinates myogenesis through the regulation of Dvl2 mRNA.
Overexpression of dishevelled 2 is associated with metastasis in hepatocellular carcinoma.
FZD4 (显示 FZD4 抗体) Tyrosine 250(2.39) is crucial for DVL2 interaction and DVL2 translocation to the plasma membrane.
we found that Wnt3a (显示 WNT3A 抗体) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3 (显示 DVL3 抗体). Our findings suggest a model of positive regulation of PKCzeta (显示 PRKCZ 抗体)-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a (显示 WNT3A 抗体) treatment by stabilizing Dvl protein levels.
Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP (显示 ZDHHC21 抗体) domain in Wnt (显示 WNT2 抗体) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling.
Data show that RAP1B (显示 RAP1B 抗体) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (显示 RAP1B 抗体) interacted with DVL2 and activated Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1 (显示 DVL1 抗体), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
CapZIP (显示 RCSD1 抗体), which has been shown to regulate ciliogenesis, is an ERK7 (显示 MAPK15 抗体) substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 (显示 MAPK15 抗体) phosphorylation of CapZIP (显示 RCSD1 抗体) through binding to both ERK7 (显示 MAPK15 抗体) and CapZIP (显示 RCSD1 抗体).
Different Dvl proteins (Dvl1 (显示 DVL1 抗体), Dvl2, Dvl3 (显示 DVL3 抗体)) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (显示 WNT2 抗体) signaling in Xenopus gastrulation.
these findings suggest that regulation of Dvl protein levels by NEDD4L (显示 NEDD4L 抗体) is essential for convergent extension during early Xenopus embryogenesis.
findings reveal that, in response to Wnt (显示 WNT2 抗体) signalling, Dishevelled inhibits CSL (显示 SMPX 抗体) transcription factors to regulate Notch (显示 NOTCH1 抗体) signalling and cell-fate decisions in vivo
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin (显示 Actbeta 抗体).
The archenteron elongation is independent of Xdsh signaling, especially during the second half of gastrulation.
Subcellular localization is insufficient to account for the pathway specificity of Dishevelled in the canonical Wnt (显示 WNT2 抗体) versus PCP (显示 PRCP 抗体) signaling cascades.
both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells
Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 (显示 EFNB1 抗体) and mediates ephrinB1 (显示 EFNB1 抗体) signalling through downstream members of the PCP (显示 PRCP 抗体) pathway during eye field formation.
The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.
Dishevelled interacts with Lurap1 (显示 C1orf190 抗体) to regulate cellular polarisation during gastrulation.
demonstrate that during early zebrafish development Nkd1 (显示 NKD1 抗体) does not alter either endogenous or exogenous levels of Dvl2
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
DSH homolog 2
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2
, dishevelled 2
, dishevelled, dsh homolog 2 (Drosophila)
, dishevelled 2 (homologous to Drosophila dsh)
, dishevelled homolog
, dishevelled 2, dsh homolog