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抗Mouse (Murine) Transferrin Receptor 2 抗体:
抗Human Transferrin Receptor 2 抗体:
抗Rat (Rattus) Transferrin Receptor 2 抗体:
Tfr2 is a key regulator of brain iron homeostasis and propose a role for Tfr2 alpha in the regulation of anxiety circuits.
erythroid Tfr2 is essential for an appropriate erythropoietic response in iron-deficient anemia
These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin (显示 SLC40A1 抗体) and thus macrophage iron homeostasis
Tfr2 is a novel target gene for HNF4alpha (显示 HNF4A 抗体), and hepatic HNF4alpha (显示 HNF4A 抗体) plays a critical role in iron homeostasis.
There is an essential role for TFR2 in erythropoiesis that may provide new targets for the treatment of anaemia.
We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo (显示 EPO 抗体) sensitivity.
We propose that TFR2 is a limiting factor for erythropoiesis, particularly in conditions of iron restriction.
These results support in vivo studies which suggest that Hfe (显示 HFE 抗体) and Tfr2 can independently regulate hepcidin (显示 HAMP 抗体).
we used microarray and real-time reverse transcription polymerase chain reaction to assess brain transcriptome profiles of transferrin receptor 2 mutant mice a model of a rare type of hereditary hemochromatosis (显示 HFE 抗体)
Double mutant mice lacking functional Hfe (显示 HFE 抗体) or Tfr2 and Tmprss6 (显示 TMPRSS6 抗体) exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 (显示 TMPRSS6 抗体) demonstrating that Hfe (显示 HFE 抗体) and Tfr2 are not substrates for Tmprss6 (显示 TMPRSS6 抗体).
In agreement with previous studies with truncated forms of these receptors, holo-Tf binds to the TfR1 (显示 TFRC 抗体) homologue significantly stronger than to TfR2.
Authors retrospectively investigated whether TFR2 isoforms and EPOR (显示 EPOR 抗体) are differentially expressed in MDS (显示 PAFAH1B1 抗体) patients and whether the expression is associated with patients' clinical outcomes.
unreported iron metabolism-related genes in non-classic hereditary hemochromatosis (显示 HFE 抗体) patients that were predicted to be potentially pathogenic were three novel mutations in TFR2 [two missense (p.Leu750Pro and p.Ala777Val) and one intronic splicing mutation (c.967-1G>C)], one missense mutation in HFE (显示 HFE 抗体) (p.Tyr230Cys), and one mutation in the 5'-UTR (显示 UTS2R 抗体) of HAMP (显示 HAMP 抗体) gene (c.-25G>A)
TFR2 expression altered within 4h of HAMP (显示 HAMP 抗体) treatment, while HFE (显示 HFE 抗体) expression altered later at 24h and 48h, suggesting that TFR2 may function prior to HFE (显示 HFE 抗体) in HAMP (显示 HAMP 抗体) regulation.
Of the non-HFE (显示 HFE 抗体) forms of iron overload, TFR2-, HFE2 (显示 HFE2 抗体)-, and HAMP (显示 HAMP 抗体)-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 (显示 SLC40A1 抗体) variants that have been previously associated with autosomal-dominant ferroportin (显示 SLC40A1 抗体) disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
Transferrin (显示 Tf 抗体) facilitates the formation of DNA double-strand breaks (DNA-DSBs) via transferrin receptor TfR1 but not TfR2.
In line with a status of iron deficiency, gene expression studies suggested decreased expression of transferrin (显示 Tf 抗体) and transferrin receptor 2 in non-alcoholic steatohepatitis livers
Our results indicate that membrane transferrin receptor-2, a sensor of circulating iron, is released from the cell membrane in iron deficiency.
results suggest that down-regulation of CD81 (显示 CD81 抗体) by GRAIL (显示 RNF128 抗体) targets TfR2 for degradation
Polymorphisms of the TRF2 (显示 TERF2 抗体) gene may be associated with age-related macular degeneration occurrence, either directly or by modulation of risk factors.
One novel SNPs was identified in TFR2 which tended to be associated (P < 0.013) with skeletal muscle iron content.
TfR2 is coexpressed with transferrin-a (显示 Tf 抗体) in the liver of the zebrafish embryo. Knockdown of TfR2 fails to produce anemia or a morphologic defect.
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
transferrin receptor 2
, transferrin receptor protein 2-like
, transferrin receptor protein 2