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抗Human SLC25A37 抗体:
抗Mouse (Murine) SLC25A37 抗体:
抗Rat (Rattus) SLC25A37 抗体:
Studied iron metabolism in polycythemia vera and essential thrombocytosis using serum levels of hepcidin, GDF15, and mitoferrin-1.
The findings of this study implicate that the SCL25A37 is a major depressive disorder susceptibility gene whose expression may influence major depressive disorder risk.
RNA-sequencing and Reverse transcriptase PCR showed higher expression of a specific isoform of SLC25A37 in SF3B1-mutant patients, a crucial importer of Fe(2+) into the mitochondria
Compares and contrasts all the known human SLC25A* genes and includes functional information.
Data show that abnormal MFRN1 expression can contribute to erythropoietic protoporphyria phenotype in some patients, probably by causing a reduction in FECH activity.
hypoxia induces the expression of mitoferrin mRNAs through separate mechanisms in erythroid cells
impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation
Mitoferrin 1 can cause anemia and protoporphyria.
The transcription factor GATA-1 controls expression of Mitoferrin 1 in development of mammals
Fech forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.
Erythroblasts generated from murine embryonic stem cells null for Mfrn (also known as Slc25a37) show maturation arrest with severely impaired incorporation of 55Fe into haem [mitoferrin]
Mitoferrin 1 and mitoferrin 2 contribute to mitochondrial iron delivery in a variety of cells.
Data show that the binding domain of Mfrn1-Abcb10 interaction maps to the N terminus of Mfrn1.
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009
mitochondrial iron transporter 1
, mitochondrial solute carrier protein
, predicted protein of HQ2217
, solute carrier family 25, member 37
, mitoferrin 1
, mitochondrial carrier domain containing protein RGD1359361
, mitochondrial solute carrier-like protein
, erythroid-specific mitochondrial mitoferrin
, protein frascati
, solute carrier family 25 member 37