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Human S100A9 Protein expressed in Wheat germ - ABIN1319076
Venkataraman, Cole, Svoboda, Pohl, Cole: Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. in Journal of immunology (Baltimore, Md. : 1950) 2005
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Human S100A9 Protein expressed in HEK-293 Cells - ABIN2731328
Yeap, Wong, Shimasaki, Teo, Quek, Yong, Diong, Bertoletti, Linn, Wong: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. in Scientific reports 2016
Authors found that downregulation of S100A9 significantly reduced the expression of NF-kappaB (显示 NFKB1 蛋白), phosphorylation of NF-kappaB (显示 NFKB1 蛋白) and Bcl-2 (显示 BCL2 蛋白), as well as the expression of MMP7 (显示 MMP7 蛋白) and MMP2 (显示 MMP2 蛋白). Restoration of NF-kappaB (显示 NFKB1 蛋白) expression sufficiently reversed the inhibitory effects on cell proliferation and invasion induced by S100A9 downregulation in vitro and in vivo.
Urinary NGAL (显示 LCN2 蛋白) is a good predictor of mortality in established pediatric acute kidney injury (AKI) of heterogeneous etiology and outperforms calprotectin (显示 S100A8 蛋白) and KIM-1 (显示 HAVCR1 蛋白). Urinary calprotectin (显示 S100A8 蛋白) and KIM-1 (显示 HAVCR1 蛋白) predict renal replacement therapy requirement in pediatric AKI.
Identify proteins that interact with calgranulin B to suppress the proliferation of colon cancer cells.
This study demonstrated that S100A9 was detected in the serums of Alzheimer disease patients
Expression levels of S100A9 and Tenascin-C (显示 TNC 蛋白) were correlated with TNM (显示 ODZ1 蛋白) stages and metastasis in colorectal cancer.
In Guatemalan preschoolers, the median fecal calprotectin (显示 S100A8 蛋白) value was 58 mg/kg, with a mean of 98 +/- 136 mg/kg and a range from 10 to 950 mg/kg; 61% of values were above the manufacturer's cut-off for elevated concentration and 51% exceeded an age-adjusted criterion. The central tendency (mean or median) and distribution were generally shifted to the right in relation to comparable reports from children across the world.
Low S100A9 expression is associated with head and neck neoplasms.
Report role of fecal calprotectin (显示 S100A8 蛋白) assay in the diagnosis and management of inflammatory bowel disease.
S100A8 (显示 S100A8 蛋白) and S100A9 aggravate Coxsackievirus B3-induced myocarditis and might serve as therapeutic targets in inflammatory cardiomyopathies.
Calprotectin (显示 S100A8 蛋白) had the highest association with ultrasound synovitis and predicted treatment response. It may thus be considered as a marker for evaluating inflammation and responsiveness in patients with rheumatoid arthritis on biologic disease-modifying anti-rheumatic drug treatment.
Data suggest that up-regulation of S100A8 (显示 S100A8 蛋白) and S100A9 is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
Study verified porcine calprotectin (S100A8 (显示 S100A8 蛋白)/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
this study shows that S100A9 inhibits B lymphopoiesis by acting on myeloid cells and promoting the release of inflammatory molecules, including IL-1beta (显示 IL1B 蛋白)
Like S100A8 (显示 S100A8 蛋白), S100A9 and S100A8 (显示 S100A8 蛋白)/A9 reduced neutrophil influx in acute lung injury provoked by lipopolysaccharide (LPS (显示 TLR4 蛋白)) challenge.
findings reveal unexpected gene expression differences between WT and KO mice at a young age (in the absence of physiological stress), and address the hypothesis that Mrp8 (显示 S100A8 蛋白) and Mrp14 accumulation promotes age-related inflammation
An excessive expansion of monocytic-myeloid-derived suppressor cells in S100A9-/- neonates compared to wild-type neonates. This strong baseline expansion was associated with hyperinflammatory responses during endotoxemia and fatal septic courses
Data support a role of S100A9 to initiate and amplify the neutrophilic inflammation in asthma, possibly via inducing IL-1beta (显示 IL1B 蛋白), IL-17 (显示 IL17A 蛋白) and IFN-gamma (显示 IFNG 蛋白).
The findings show that reduced PTP1B (显示 PTPN1 蛋白) responses contribute to disease symptoms in part by enhancing S100A9 expression during viral-associated chronic obstructive pulmonary disease exacerbations.
Neutrophil-derived S100A8 (显示 S100A8 蛋白)/A9 promotes thrombocytosis in diabetic mice
S100A9 knockdown almost completely abrogated the effects of IRF7 (显示 IRF7 蛋白) deletion on granulocytic myeloid-derived suppressor cells development and tumor metastasis.
Perinatal alarmins S100A8 (显示 S100A8 蛋白) and S100A9 specifically altered MyD88 (显示 MYD88 蛋白)-dependent proinflammatory gene programs. S100 programming prevented hyperinflammatory responses without impairing pathogen defense. TRIF (显示 RNF138 蛋白)-adaptor-dependent regulatory genes remained unaffected by perinatal S100 programming and responded strongly to lipopolysaccharide, but were barely expressed.
vitro studies on the mechanisms/pathways involved in leukemic cell differentiation revealed that binding of S100A9 to Toll-like receptor 4 (TLR4 (显示 TLR4 蛋白)) promotes activation of p38 mitogen-activated protein kinase (显示 MAPK14 蛋白), extracellular signal-regulated kinases 1 and 2, and Jun N-terminal kinase (显示 MAPK8 蛋白) signaling pathways, leading to myelomonocytic and monocytic AML (显示 RUNX1 蛋白) cell differentiation.
Calprotectin (显示 S100A8 蛋白) expression in laminar epidermis occurs after extravasation of leukocytes indicating that leukocyte emigration may be an initiating factor in laminar epithelial stress and inflammation in black walnut extract-induced laminitis.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.
, S100 calcium-binding protein A9 (calgranulin B)
, calgranulin B
, calprotectin L1H subunit
, leukocyte L1 complex heavy chain
, migration inhibitory factor-related protein 14
, protein S100-A9
, S100 calcium binding protein A9 (calgranulin B)
, intracellular calcium-binding protein (MRP14)
, myeloid-related protein 14
, protein MRP-126
, S100 calcium binding protein A9
, S100 calcium-binding protein A9
, neutrophil cytosolic 23 kDa protein
, RNA-binding region containing protein 2-like