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Human S100A8 Protein expressed in Wheat germ - ABIN1319072
Maiseyeu, Badgeley, Kampfrath, Mihai, Deiuliis, Liu, Sun, Parthasarathy, Simon, Croce, Rajagopalan: In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles. in Arteriosclerosis, thrombosis, and vascular biology 2012
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Human S100A8 Protein expressed in Escherichia coli (E. coli) - ABIN2181719
Gruda, Ruggeberg, OSullivan, Guliashvili, Scheirer, Golobish, Capponi, Chan: Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beads. in PLoS ONE 2017
Mouse (Murine) S100A8 Protein expressed in Escherichia coli (E. coli) - ABIN5569738
Schneider, Schenone, Ferreira, Kramann, Joyce, Hartigan, Beier, Brümmendorf, Germing, Platzbecker, Büsche, Knüchel, Chen, Waters, Chen, Chu, Novina, Lindsley, Carr, Ebert: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. in Nature medicine 2016
Study found that that the co-stimulation with both advanced glycation end-products and Porphyromonas gingivalis LPS (显示 IRF6 蛋白) increased S100A8 and S100A9 (显示 S100A9 蛋白) mRNA expression in gingival epithelial cells. These results demonstrated that the upregulation of calprotectin in gingival epithelial cells may primarily function intracellularly in this tissue and may contribute to the pathological process of periodontitis.
Our results showed that S100A8/A9, absent or present at very low level in skin biopsies from healthy subjects, is dramatically upregulated in each epidermal layer from psoriatic patients.
The results suggest that the calcium-binding proteins S100A8 and S100A9 (显示 S100A9 蛋白) in myeloid cells have an immune regulatory effect.
Median MRP8/14 levels were higher in patients with Takayasu arteritis.
S100A8 gene knockdown reduced cell proliferation in the HEC (显示 NDC80 蛋白)-1A cells compared with control cells, induced cell apoptosis, inhibited the phosphorylation of protein kinase B (Akt (显示 AKT1 蛋白)), and induced the expression of pro-apoptotic genes.
Wide intra- and interindividual differences in calprotectin concentrations in the meconium may reflect intestinal inflammation associated with the fetal adaptation to life outside the uterus.
Salivary calprotectin levels were significantly higher in RAS [Recurrent aphthous stomatitis] group (23.72 +/- 4.28 mg/L) compared to the HC [Healthy Controls] (21.59 +/- 4.27 mg/L) (P = 0.013). No significant relationship was found between calprotectin levels and age or gender in both groups (P >0.05).
the levels of S100A8 and S100A9 (显示 S100A9 蛋白) in the sera, and calprotectin levels in the sera and urines of bladder cancer patients, were determined.
MRP-8/14 concentration increases in coronary artery blood in association with thrombus formation in acute coronary syndrome.
ANGPTL6 (显示 ANGPTL6 蛋白), S100A8 and S100A9 (显示 S100A9 蛋白) are overexpressed in skin of psoriasis patients versus zero expression in controls.
study of nonsynonymous DNA variation in the functional domain of the S100A7 (显示 S100A7 蛋白), -A8, -A9 genes in taurine cattle and yak
Data suggest that up-regulation of S100A8 and S100A9 (显示 S100A9 蛋白) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
Study verified porcine calprotectin (S100A8/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
Specific NLRC4 (显示 NLRC4 蛋白) activation in Mrp8 (+) cells (primarily neutrophil lineage) is sufficient to cause severe inflammatory disease.
We present the reconstitution, purification, and characterization of mCP (显示 CR1L 蛋白) as well as the cysteine-null variant mCP (显示 CR1L 蛋白)-Ser (显示 SIGLEC1 蛋白). Apo (显示 C9orf3 蛋白) mCP (显示 CR1L 蛋白) is a mS100A8/mS100A9 heterodimer, and Ca(II (显示 CA2 蛋白)) binding causes two heterodimers to self-associate and form a heterotetramer
S100A8 was required for laser-induced new collagen synthesis in skin cells.
Chronic Pseudomonas aeruginosa biofilm infection reduces murine S100A8/ S100A9 (显示 S100A9 蛋白) expression and delays species-specific burn wound closure.
data suggest that S100A8/A9 acts directly on BV-2 microglial cells via binding to TLR4 (显示 TLR4 蛋白) and RAGE (显示 AGER 蛋白) on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (显示 EPHB2 蛋白) and JNK (显示 MAPK8 蛋白)-mediated NF-kappaB (显示 NFKB1 蛋白) activity in BV-2 microglial cells.
The results obtained in the present study demonstrate for the first time that S100A8 as well as MyD88 (显示 MYD88 蛋白) and NF-B are activated by T3 and that these molecules are directly involved in the thyroid hormone (显示 PTH 蛋白)-induced cardiac hypertrophic response. These data suggest that one of the mechanisms underlying T3-dependent cardiac hypertrophy/failure may involve the activation of an inflammatory pathway.
Like S100A8, S100A9 (显示 S100A9 蛋白) and S100A8/A9 reduced neutrophil influx in acute lung injury provoked by lipopolysaccharide (LPS (显示 TLR4 蛋白)) challenge.
theses findings reveal unexpected gene expression differences between WT and KO mice at a young age (in the absence of physiological stress), and address the hypothesis that Mrp8 and Mrp14 (显示 S100A9 蛋白) accumulation promotes age-related inflammation
S100A8 and S100A9 (显示 S100A9 蛋白) aggravate Coxsackievirus B3-induced myocarditis and might serve as therapeutic targets in inflammatory cardiomyopathies.
Neutrophil-derived S100A8/A9 promotes thrombocytosis in diabetic mice
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
, S100 calcium-binding protein A8 (calgranulin A)
, calgranulin A
, calprotectin L1L subunit
, cystic fibrosis antigen
, leukocyte L1 complex light chain
, migration inhibitory factor-related protein 8
, protein S100-A8
, urinary stone protein band A
, S100 calcium binding protein A8 (calgranulin A)
, S100 calcium binding protein A8
, S100 calcium-binding protein A8
, neutrophil cytosolic 7 kDa protein
, chemotactic S100 protein
, chemotactic cytokine CP-10
, pro-inflammatory S100 cytokine
, macrophage migration inhibitory factor-related protein-8