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Human Polyclonal NEO1 Primary Antibody for ICC, IF - ABIN4338577
Tanabe, Yamashita: Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis. in Cell reports 2014
Alternative splicing generates several isoforms of zneo1, most of which are developmentally regulated, showing distinct distribution in brain and other tissues
up and downregulation of neogenin signaling was associated with mitochondrial activity in embryos.
The results indicate that RGMB-neogenin-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the developing olfactory epithelium.
Thus, our findings identify an unrecognized function of neogenin in mouse neocortical astrocyte differentiation, and suggest a signaling pathway, BMP2-neogenin-YAP-Smad1, underlying astrogliogenesis in developing mouse neocortex.
Results indicate that an efficient induction of hepcidin expression by hemojuvelin (HJV) requires its interaction with neogenin.
Neogenin acts to synchronize neuroblast migration and terminal differentiation through the regulation of neuroblast cell cycle kinetics within the neurogenic microenvironment of the RMS.
these results highlight Neogenin1 as a novel downstream effector of the Sonic Hedgehog pathway in medulloblastoma
Strong expression of RGMa, RGMb and Neogenin protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus.
neogenin appears to suppress Myo X movement on the basal side, but increases its movement towards the apical and dorsal side of a cell, promoting dorsal filopodium formation and growth
guidance receptor neogenin holds crucial importance for the propagation of an acute inflammatory response and further define mechanisms shared between the nervous and the immune system.
identification of neogenin-binding site on the repulsive guidance molecule A
these findings indicate that neogenin regulates SHH signaling in the limb bud to achieve proper digit patterning.
Data show that neogenin influences neutrophil migration across endothelial HMEC-1 and alveolar A549 monolayers in vitro.
These findings show direct regulation of neogenin by the Rb/E2F3 pathway and demonstrate that regulation of neogenin expression is required for neural precursor migration.
This study supports the hypothesis that, as in the embryo, neogenin regulates fundamental signalling pathways important for neurogenesis in the adult mouse and human forebrain.
neogenin promotes chondrogenesis in vitro and in vivo, revealing an unexpected mechanism underlying neogenin regulation of BMP signaling
Neogenin regulates iron homeostasis via inhibiting secretion of HJV, an inhibitor of bone morphogenetic protein (BMP) signaling, to enhance BMP signaling and hepcidin expression.
Data suggest that neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase, and that netrin-2 activates FAK and ERK in cultured myoblasts in a neogenin-dependent manner.
netrin-3 and neogenin may promote myogenic differentiation by an autocrine mechanism as components of a higher order complex of several promyogenic cell surface proteins
A key receptor in the establishment of the morphological architecture in many developing organ systems.
RGMa-mediated neogenin signal transduction pathway involved in axonal guidance.
Overexpression of Neo1 significantly reduced the GC cell sensitivity to cisplatin and increased the cell viability, motility and adhesion ability, and while silencing of Neo1 showed contrary results.
Endogenous NTN4/NEO1 maintain neuroblastoma growth via both pro-survival and pro-migratory molecular signaling.
Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin.
these results suggested that GD3 recruits gamma-secretase to lipid/rafts, allowing efficient cleavage of neogenin.
The hemizygous 15q deletion unmasks the recessive functional polymorphism in NEO1 which plays a pivotal role in cortical interneuron development; study provides the first evidence linking NEO1 with autism spectrum disorders in humans
Neogenin influences both cadherin dynamics and junctional tension.
Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways
The present study demonstrates that neogenin may be a tumor suppressor in breast cancer. Neogenin may serve as a potential diagnostic marker and therapeutic target for breast cancer.
These results show how repulsive guidance molecule acts as the central hub that links BMP2 and NEO1 and physically connects these fundamental signaling pathways.
Neogenin expression is inversely associated with breast cancer grade.
high-expression of neogenin-1 promotes gastric cancer proliferation and motility
miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin.
two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner.
neogenin forms a ternary complex with both MT2 and HJV at the plasma membrane. The complex facilitates HJV cleavage by MT2, and release of the cleaved HJV from the cell occurs after a retrograde trafficking through the TGN/Golgi compartments.
pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells
the proposed role of neogenin as a tumor suppressor in gliomas
Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B.
Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer.
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants.
, neogenin 1
, neogenin homolog 1
, immunoglobulin superfamily DCC subclass member 2