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Human Hemopexin Protein expressed in Human - ABIN5662823
Kozlik, Sanda, Goldman: Nano reversed phase versus nano hydrophilic interaction liquid chromatography on a chip in the analysis of hemopexin glycopeptides. in Journal of chromatography. A 2017
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Data suggest that apo (显示 C9orf3 蛋白)-hemopexin isolated from plasma exchibits low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins; heme binding by hemopexin declined as tyrosine nitration proceeded in vitro.
There were significantly higher serum concentrations of fetal hemoglobin (显示 HBB 蛋白) and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia.
HPX is upregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease.
Plasma hemopexin levels were decreased or markedly decreased in patients with burns or sepsis and in premature infants.
Data show that HPX, POTEE and ApoA1 (显示 APOA1 蛋白) are deregulated in breast tumors suggesting un important role in breast tumorigenesis.
The Bach1 (显示 BACH1 蛋白)-dependent repression of the HO-1 (显示 HMOX1 蛋白) expression is under the control of the Hemopexin-dependent uptake of extracellular he
Hemopexin is overexpressed in the RPE (显示 RPE 蛋白) of diabetic patients with DME and induces the breakdown of RPE (显示 RPE 蛋白) cells in vitro.
activated hemopexin might be considered as a factor mediating ang II (显示 AGT 蛋白) effects upon blood pressure by modulating AT1-R (显示 AGTR1 蛋白) availability
hemopexin will be neuroprotective after traumatic brain injury, with heme release in the CNS, and during the ensuing inflammation.
In sum, these data indicated that AKI-associated hepatic stress generates Hpx, which gains renal tubule access.
two glycoproteins, AHSG (显示 AHSG 蛋白) and HPX, represent a pivotal glycoprotein of the cytoprotective activity for WN1316, showing a concrete evidence for the novel glycan-independent function of serum glycoproteins in neuroprotective drug efficacy.
Hemopexin plays a novel protective role in alleviating heme-induced oxidative stress, improving inflammatory properties of high-density lipoprotein, macrophage phenotype and function, and inhibiting the development of atherosclerosis in apoE (显示 APOE 蛋白)(-/-) mice.
This study demonstrated that Deletion of the hemopexin aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage
In models for sepsis or burns, mean plasma hemopexin levels were increased above baseline.
The findings suggest that hemopexin can modulate the role of hemoglobin in sterile and infectious inflammation
results demonstrate that hemopexin decreases the accumulation and catabolism of exogenous hemin by neural cells. Its beneficial effect in stroke models is unlikely to be mediated by increased production of cytoprotective heme breakdown products
Hemopexin deficiency, which is often associated with sickle cell disease, may worsen outcome after intracerebral hemorrhage
haptoglobin (显示 HP 蛋白) and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis
the importance of hemopexin in heme detoxification, thus suggesting that drugs mimicking hemopexin activity might be useful to prevent endothelial damage in patients suffering from hemolytic disorders.
hemopexin, by controlling heme-iron availability in lymphocytes, modulates responsiveness to IFN-gamma (显示 IFNG 蛋白) and, hence, autoimmune responses
Our data suggest that Hx, which is an acute-phase protein (显示 ORM1 蛋白) that increases during inflammation, limits TLR4 (显示 TLR4 蛋白) and TLR2 agonist-induced macrophage cytokine production directly through a mechanism distinct from HO-1 (显示 HMOX1 蛋白).
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress.