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LGMN 蛋白

(Legumain (LGMN))
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].
LGMN Protein (AA 18-435) (His tag) LGMN Protein (AA 18-435) (His tag) LGMN Protein (AA 18-435) (His tag) (ABIN7275145)

LGMN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

LGMN Protein (AA 18-433) (His tag) LGMN Protein (AA 18-433) (His tag) LGMN Protein (AA 18-433) (His tag) (ABIN7275144)

LGMN 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

LGMN Protein (AA 18-325) (His-IF2DI Tag) LGMN Protein (AA 18-325) (His-IF2DI Tag) LGMN Protein (AA 18-325) (His-IF2DI Tag) (ABIN7123739)

LGMN 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

LGMN 蛋白 by Grade

Find LGMN 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

LGMN 蛋白 by Origin

Find LGMN 蛋白 for a variety of species such as anti-Human LGMN, anti-Mouse LGMN, anti-CHO cells LGMN. The species listed below are among those available. Click on a link to go to the corresponding products.

LGMN 蛋白 by Source

Here you will find LGMN 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

LGMN 蛋白 by 蛋白类型

Here you can find LGMN 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

LGMN 蛋白 by 应用范围

Find LGMN 蛋白 validated for a specific application such as ELISA, WB, SDS, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

LGMN 蛋白 by 生物活性

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Popular LGMN 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275145
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7275144
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123739
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309356
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7196760
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3082886
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3132294
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7520267
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396532
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413253
Quantity 100 μg
Datasheet Datasheet
Reactivity CHO cells
Source Insect Cells
Validations
Cat. No. ABIN7126042
Quantity 0.5 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2724612
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2724611
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
Cat. No. ABIN7479365
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Yeast
Validations
Cat. No. ABIN7478981
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our LGMN 蛋白

Zhao, Hua, Crowley, Ru, Ni, Shaw, Jiao, Ding, Qu, Hung, Huang, Liu, Ye, Ouyang, Cheng, Liu: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." in: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).

Liu, Xiong, Gong, Zhang, Bai, Luo, Li, Wei, Liu, Tan, Xiang: "Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment." in: Nature communications, Vol. 5, pp. 4280, (2014) (PubMed).

Hasegawa, Yamasaki, Fukui: "Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidney." in: Biochemical and biophysical research communications, Vol. 453, Issue 3, pp. 631-5, (2014) (PubMed).

Aliases for LGMN 蛋白

legumain (LGMN) 蛋白
legumain (Lgmn) 蛋白
legumain L homeolog (lgmn.L) 蛋白
legumain (lgmn) 蛋白
delta vacuolar processing enzyme (DELTA-VPE) 蛋白
legumain (MBOO_RS07785) 蛋白
Legumain (Odosp_3582) 蛋白
legumain (LOC569153) 蛋白
AEP 蛋白
AI746452 蛋白
AU022324 蛋白
cb173 蛋白
cb460 蛋白
DELTA VACUOLAR PROCESSING ENZYME 蛋白
delta vacuolar processing enzyme 蛋白
DELTAVPE 蛋白
lgmn 蛋白
LGMN1 蛋白
MGC64351 蛋白
MGC88980 蛋白
PRSC1 蛋白
Prsc1 蛋白
sb:cb173 蛋白
wu:fa98g05 蛋白
wu:fj92g08 蛋白
zgc:76953 蛋白
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