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抗Human TLR4 抗体:
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Human Monoclonal TLR4 Primary Antibody for ChIP, CyTOF - ABIN252522
Kessel, Toubi, Pavlotzky, Mogilner, Coran, Lurie, Karry, Sukhotnik et al.: Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by ... in Clinical and experimental immunology 2008
Show all 63 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360113
Rallabhandi, Bell, Boukhvalova, Medvedev, Lorenz, Arditi, Hemming, Blanco, Segal, Vogel: Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 45 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS - ABIN252065
Konno, Wakabayashi, Akashi-Takamura, Ishii, Kobayashi, Takahashi, Kusumoto, Saitoh, Yoshizawa, Miyake: A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. in Biochemical and biophysical research communications 2005
Show all 24 Pubmed References
Human Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360167
Degraaf, Zasłona, Bourdonnay, Peters-Golden: Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation. in American journal of respiratory cell and molecular biology 2014
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS - ABIN4360117
Mempel, Voelcker, Köllisch, Plank, Rad, Gerhard, Schnopp, Fraunberger, Walli, Ring, Abeck, Ollert et al.: Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet ... in The Journal of investigative dermatology 2003
Show all 23 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360119
Basak, Pathak, Bhattacharyya, Mandal, Pathak, Kundu et al.: NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori ... in The Journal of biological chemistry 2005
Show all 22 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS, ICC - ABIN4360164
Cognasse, Hamzeh, Chavarin, Acquart, Genin, Garraud: Evidence of Toll-like receptor molecules on human platelets. in Immunology and cell biology 2005
Show all 21 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, ELISA - ABIN4360158
Scheel, Papavlassopoulos, Blunck, Gebert, Hartung, Zähringer, Seydel, Schromm: Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. in Infection and immunity 2006
Show all 18 Pubmed References
Human Monoclonal TLR4 Primary Antibody for FACS - ABIN4360193
Zanoni, Navone, Lunardi, Tridente, Bason, Sivori, Beri, Dolcino, Valletta, Corrocher, Puccetti: In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. in PLoS medicine 2006
Show all 16 Pubmed References
Human Monoclonal TLR4 Primary Antibody for FACS - ABIN4360159
Allam, Peng, Appel, Wenghoefer, Niederhagen, Bieber, Bergé, Novak: Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. in The Journal of allergy and clinical immunology 2008
Show all 15 Pubmed References
Prolonged hypertension influences peripheral monocyte TLR4 expression and IL-17A (显示 IL17A 抗体) serum levels
TLR4-stimulated oral keratinocytes inhibited the proliferation of oral lichen planus CD4 (显示 CD4 抗体)(+) T cells and CD8 (显示 CD8A 抗体)(+) T cells, and simultaneously prompted their apoptosis.
Reduced expression of caveolin-1 (显示 CAV1 抗体) in monocytes could aggravate the TLR4-mediated inflammatory cascade
the role of TLR4 in angiogenesis could be of value in various settings related to tissue repair and tissue engineering. Moreover, since LPS (显示 IRF6 抗体) and TLR4 agonists improve angiogenesis and osteogenesis, TLR4 agonists (endogenous or synthetic) could be used for angiogenesis intervention in vivo.
PTX treatment of THP-1 macrophages for 1 h induced marked intranuclear translocation of NF-kappaB p65. Low-dose PTX inhibited the M2 phenotype and induced the M1 phenotype via TLR4 signaling, suggesting that low-dose PTX can alter the macrophage phenotype, whereas clinical doses can kill cancer cells. These results suggest that the anticancer effects of PTX are due both to its cytotoxic and immunomodulatory activities
recombinant NS1, expressed and purified from eukaryotic cells, induces cytokine production via TLR4 but not TLR2/6.
Upregulation of TLR-4 on CD14 (显示 NDUFA2 抗体)(++)CD16 (显示 CD16 抗体)(+)monocytes might be associated with coronary plaque vulnerability in patients with stable angina pectoris.
The minor alleles of TLR2-rs3775290, TLR4-rs7873784, and TLR9 (显示 TLR9 抗体)-rs352140, and interaction between rs352140 and HPV infection were all associated with increased cervical cancer risk.
assess the role of TLR2 and TLR4 gene expression as an early marker for the risk of doxorubicin-induced cardiomyopathy in
MD-2 (显示 LY96 抗体) siRNA or plasmid further confirmed the efficacy of Iturin A by suppressing MD-2 (显示 LY96 抗体)/TLR4 signaling pathway. The in silico docking study showed that the Iturin A interacted well with the MD-2 (显示 LY96 抗体) in MD-2 (显示 LY96 抗体)/TLR4 receptor complex. Conclusively, inhibition of MD-2 (显示 LY96 抗体)/TLR4 complex with Iturin A offered strategic advancement in cancer therapy.
Vitamin K2 can inhibit intimal calcification of aortic artery induced by high-fat diet in ApoE(-/-) mice via suppression of TLR2/4 expression.
Endotoxaemia enhanced early venous thrombosis occurs in a TLR-4 and ICAM-1 (显示 ICAM1 抗体) dependent fashion, and is potentiated by neutropenia.
TLR4-independent lipopolysaccharide uptake is promoted by kukoamine B in hepatocytes
This study provides new molecular insight into the ability of miR (显示 MLXIP 抗体)-29a to inhibit TLR2 and TLR4 signaling, which thus slows the progression of cholestatic liver deterioration.
Hyperin inhibited lipopolysaccharide-induced inflammatory response in acute kidney injury by inhibiting TLR4 and NLRP3 (显示 NLRP3 抗体) signaling pathways.
tissue damage induced NADPH oxidase (显示 NOX1 抗体) activation and increased the release of reactive oxygen species via cold-inducible RNA-binding protein (CIRP (显示 CIRBP 抗体))-TLR4-MyD88 (显示 MYD88 抗体) signaling.
the anti-inflammatory effect of Saikosaponin a is associated with activating LXRalpha (显示 NR1H3 抗体) dependent cholesterol efflux pathway which result in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 to lipid rafts, thereby attenuating LPS mediated inflammatory response
analysis of TLR2 rs5743708, TLR2 rs4696480, TLR4 rs4986790, TLR9 (显示 TLR9 抗体) rs5743836 and TLR9 (显示 TLR9 抗体) rs352140 SNPs in children with pneumococcal and meningococcal meningitis and their family members; study did not show an association between the analyzed SNPs in TLR2, TLR4, and TLR9 (显示 TLR9 抗体) and susceptibility to develop bacterial meningitis
TLR4 deletion does not protect from cast immobilization-induced muscle atrophy.
a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
STA3 (显示 ARHGEF3 抗体) facilitates TLR4-dependent IL-6 (显示 IL6 抗体) and IL-8 (显示 IL8 抗体) production via IL-6 (显示 IL6 抗体) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (显示 IL8 抗体) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 (显示 CD14 抗体) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (显示 NFKB1 抗体) (p65 (显示 SYT1 抗体)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (显示 NFKB1 抗体) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (显示 ICAM1 抗体).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (显示 ACSM3 抗体) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (显示 ACSM3 抗体).
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (显示 MAMLD1 抗体) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (显示 IRF6 抗体) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (显示 CD180 抗体)/MD1 (显示 LY86 抗体) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (显示 CLPTM1 抗体), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (显示 HPSE 抗体) axis induced by LPS (显示 IRF6 抗体) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (显示 LY96 抗体) and CD14 (显示 CD14 抗体) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (显示 LY96 抗体) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein