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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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20.974096 | ABIN266066 | ICC IF IP SimWes WB | Rabbit | Internal Region | Log in to see | Polyclonal | 26 | |||
19.545948 | ABIN2855929 | ICC IF WB | Rabbit | IgG | C-Term | Log in to see | Polyclonal | 0 | ||
17.302011 | ABIN1169062 | IP WB | Rabbit | AA 4-31, N-Term | Log in to see | Polyclonal | 3 | |||
16.743937 | ABIN1871543 | ICC IHC WB | Rabbit | IgG | AA 443-685 | Log in to see | Polyclonal | 0 | ||
16.743937 | ABIN1875095 | IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
16.743937 | ABIN2903154 | IF/ICC IHC IP WB | Rabbit | AA 443-685 | Log in to see | Polyclonal | 0 | |||
15.2439375 | ABIN3044491 | IHC (fro) IHC (p) WB | Rabbit | IgG | AA 692-712, C-Term | Log in to see | Polyclonal | 1 | ||
13.7439375 | ABIN6265566 | ELISA IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
12.8020115 | ABIN2613488 | ELISA WB | Goat | Internal Region | Log in to see | Polyclonal | 0 | |||
12.8020115 | ABIN4902391 | ELISA WB | Rabbit | IgG | AA 663-712 | Log in to see | Polyclonal | 0 | ||
12.8020115 | ABIN6149149 | WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
12.2439375 | ABIN541214 | IHC (p) WB | Rabbit | Log in to see | Polyclonal | 3 | ||||
10.7439375 | ABIN3029185 | IHC (fro) IHC (p) WB | Rabbit | Ig Fraction | C-Term | Log in to see | Polyclonal | 0 | ||
10 | ABIN213993 | IHC IHC (p) WB | Rabbit | IgG | C-Term | Log in to see | Polyclonal | 0 | ||
10 | ABIN6292306 | IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
9.2439375 | ABIN1881885 | WB | Rabbit | AA 115-143, N-Term | Log in to see | Polyclonal | 5 | |||
9.2439375 | ABIN537469 | WB | Rabbit | Log in to see | Polyclonal | 3 | ||||
7.743937 | ABIN3223003 | IHC WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
7.743937 | ABIN1030771 | IHC ELISA WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
7 | ABIN457458 | IHC IHC (p) WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 |
General |
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抗原 | Toll-Like Receptor Adaptor Molecule 1 (TICAM1) 抗体 |
适用 | 小鼠, 大鼠, 人 其他选择 |
宿主 | 兔 其他选择 |
克隆类型 | |
标记 | This TICAM1 antibody is un-conjugated 其他选择 |
应用范围 |
Immunohistochemistry (IHC), Western Blotting (WB)
其他选择
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找到1个引用 |
Supplier | Log in to see |
TICAM1抗体详情TICAM1目标详情 使用细节 贮存及处理 References for anti-TICAM1 antibody (ABIN3021572) 图像 |
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纯化方法 | Affinity purification |
免疫原 | Recombinant protein of human TICAM1 |
亚型 | IgG |
Plasmids, Primers & others | |
TICAM1目标详情TICAM1抗体详情 使用细节 贮存及处理 References for anti-TICAM1 antibody (ABIN3021572) 图像 回页首 |
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抗原 | |
别名 | TICAM1 (TICAM1 Antibody 摘要) |
背景 |
Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-kappaB, IRF3 and trigger IFN-beta production. Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively. TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-kappaB activation. In addition, TRIF can trigger signaling of that lead to the induction of apoptosis. Synonyms: TRIF, PRVTIRB, TICAM-1 |
基因ID | 148022 |
UniProt | Q8IUC6 |
途径 | TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades |
使用细节TICAM1抗体详情 TICAM1目标详情 贮存及处理 References for anti-TICAM1 antibody (ABIN3021572) 图像 回页首 |
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应用备注 | Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200 |
限制 | 仅限研究用 |
贮存及处理TICAM1抗体详情 TICAM1目标详情 使用细节 References for anti-TICAM1 antibody (ABIN3021572) 图像 回页首 |
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状态 | Liquid |
缓冲液 | PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3 |
储存液 | Sodium azide |
注意事项 | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
注意事项 | Avoid freeze / thaw cycles |
储存条件 | -20 °C/-80 °C |
References for anti-TICAM1 antibody (ABIN3021572)TICAM1抗体详情 TICAM1目标详情 使用细节 贮存及处理 图像 回页首 |
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有引用在: |
Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." in: Frontiers in molecular neuroscience, Vol. 10, pp. 409, 2017 Method employed by authors: Western Blotting (WB) |
图像TICAM1抗体详情 TICAM1目标详情 使用细节 贮存及处理 References for anti-TICAM1 antibody (ABIN3021572) 回页首 |
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厂商提供的图像 |