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Cow (Bovine) Monoclonal TBK1 Primary Antibody for ICC, IF - ABIN252648
Merimi, Klener, Szynal, Cleuter, Kerkhofs, Burny, Martiat, Van den Broeke: Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code. in Journal of virology 2007
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Human Monoclonal TBK1 Primary Antibody for WB - ABIN967614
Kishore, Huynh, Mathialagan, Hall, Rouw, Creely, Lange, Caroll, Reitz, Donnelly, Boddupalli, Combs, Kretzmer, Tripp: IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. in The Journal of biological chemistry 2002
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Human Polyclonal TBK1 Primary Antibody for ICC, ELISA - ABIN1002907
Pomerantz, Baltimore: NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. in The EMBO journal 2000
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Human Monoclonal TBK1 Primary Antibody for ICS - ABIN1176941
Viatour, Merville, Bours, Chariot: Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. in Trends in biochemical sciences 2005
Human Polyclonal TBK1 Primary Antibody for WB - ABIN151881
Xie, Zhang, Zhao, Lu, You, Condorelli, Wang, Guan: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2011
this study shows that STAT6 (显示 STAT6 抗体) negatively regulates IFNphi1 production by attenuating the kinase activity of TANK-binding kinase 1
Fish IRF6 (显示 IRF6 抗体) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (显示 MYD88 抗体) and TBK1, suggesting that differences in the IRF6 (显示 IRF6 抗体) regulation pattern exist between lower and higher vertebrates.
Given the critical roles of TBK1, important regulatory mechanisms are required to regulate its activity. Among these, Optineurin (Optn (显示 OPTN 抗体)) was shown to negatively regulate the interferon (显示 IFNA 抗体) response, in addition to its important role in membrane trafficking, protein secretion, autophagy and cell division.
we detected no statistical difference in age at diagnosis or maximum IOP when we compared patients with a TBK1 gene duplication and patients with a TBK1 gene triplication.
Human T-lymphotropic virus 1 Tax (显示 CNTN2 抗体) protein impairs K63-linked ubiquitination of STING and disrupted the interactions between STING and TBK1 to evade host innate immunity.
we investigated a large European study population of 2,538 European FTD (显示 FTL 抗体)-ALS (显示 IGFALS 抗体) spectrum patients to get a deeper appreciation of the mutation frequency, mutation spectrum, and the genotype-phenotype profile of TBK1 patient carriers.
These results outline a novel mechanism for the control of TBK1 activity and suggest USP1 (显示 USP1 抗体)-UAF1 (显示 WDR48 抗体) complex as a potential target for the prevention of viral diseases.
TRIM9s undergoes Lys (显示 LYZ 抗体)-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta (显示 GSK3b 抗体) to TBK1, leading to the activation of IRF3 (显示 IRF3 抗体) signaling.
YPEL5 silencing enhanced the induction of IFNB1 (显示 IFNB1 抗体) by pattern recognition receptors and phosphorylation of TBK1/IKBKE (显示 IKBKE 抗体) kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE (显示 IKBKE 抗体).
ZIKV infection of neuroepithelial stem cells and radial glial cells causes centrosomal depletion and mitochondrial sequestration of phospho-TBK1 during mitosis.
High TBK1 expression is associated with Lung cancer.
Our results highlight an unexpected role of the Golgi apparatus in innate immunity as a key subcellular gateway for TBK1 activation after RNA virus infection.
IL-17 (显示 IL17A 抗体) inhibits adipogenesis where a lack of IL-17 (显示 IL17A 抗体) ameliorates glucose metabolism. As well, the inhibition of TBK1 reduces inflammation induced by IL-17 (显示 IL17A 抗体). Therefore, IL-17 (显示 IL17A 抗体) may be involved in the development of obesity and metabolic dysfunction in a TBK1-dependent manner.
Data show that TBK1 directly interacts with Exo84 (显示 EXO84 抗体) through the coiled-coil domain of TBK1 and helical domain of Exo84 (显示 EXO84 抗体), and knockdown of TBK1 blocked insulin (显示 INS 抗体)-stimulated glucose uptake and GLUT4 (显示 SLC2A4 抗体) translocation.
The TBK1 Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1
HERP (显示 HERPUD1 抗体) Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress
these studies reveal an additional regulatory function of TRIM8 (显示 TRIM8 抗体) in innate immune responses: TRIM8 (显示 TRIM8 抗体) catalyzes polyubiquitination of TRIF (显示 RNF138 抗体), resulting in disruption of TRIF (显示 RNF138 抗体)-TBK1 interaction
TBK1 regulates p16 (显示 CDKN2A 抗体) expression and retinal ganglion cell senescence.
USP38 inhibits type I interferon (显示 IFNA 抗体) signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
The authors report that Raf kinase inhibitory protein (RKIP (显示 PEBP1 抗体)) is essential for TBK1 activation and type I interferon (显示 IFNA 抗体) production triggered by viral infection.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (显示 FOSL1 抗体) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (显示 TRAF3 抗体)), TIR domain-containing adapter inducing IFN-beta (显示 IFNB1 抗体) (TRIF (显示 RNF138 抗体)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (显示 TRAF3 抗体) and TRIF (显示 RNF138 抗体).
TBK1 complexes required for the phosphorylation of IRF3 (显示 IRF3 抗体) and the production of interferon-beta (显示 IFNB1 抗体) have been identified.
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
serine/threonine-protein kinase TBK1
, TANK-binding kinase 1
, NF-kappa-B-activating kinase
, TANK binding kinase 1
, serine/threonine protein kinase TBK1
, serine/threonine-protein kinase TBK1-like
, NF-kB-activating kinase