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Studied the importance of selenium in bovine female reproductive function. Gene expression analysis revealed selenoprotein gene GPX1 was significantly up-regulated in large healthy follicles.
did not find any significant inhibition of bovine GPx-1 by (S)- or (R)-misonidazole.
Data indicate mRNA level and activity of GPx1 are regulated by level of selenium supplied to hepatocytes.
homocysteine decreases GPx1 activity by altering the translational mechanism
glutathione peroxidase-1 activity is decreased by aminoglycosides through interference with selenocysteine incorporation
GPx1 plays a key role in blocking the promotion of porcine circovirus type 2 replication
The developmental expression of GPX1 and thioredoxin reductase during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported.
Notably, CUEDC2 (显示 CUEDC2 蛋白) promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33 (显示 TRIM33 蛋白))-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1) ubiquitination, and proteasome-dependent degradation.
GPx1 does not clearly exacerbate hyperoxia-induced increases in oxidative stress or lung injury but may alter pulmonary immune function.
GPx-1 expression deters the unfolded protein response following exposure to cigarette smoke
Glutathione peroxidase 1 (GPx1) knockdown not only induced oxidative stress characterized by the increased production of reactive oxygen species (ROS (显示 ROS1 蛋白)) but also caused reductive stress indicated by an elevation of glutathione (GSH)/oxidized GSH (GSSG) ratio.
Exposure to far infrared rays significantly protects acute restraint stress oxidative burdens via inhibition of JAK2 (显示 JAK2 蛋白)/STAT3 (显示 STAT3 蛋白) signaling by induction of GPx-1.
Genetic inhibition of Gpx1 potentiates cocaine-induced renal damage via activation of AT1R (显示 AGTRAP 蛋白) by inhibition of PI3K-Akt (显示 AKT1 蛋白) signaling.
Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced liver injury by induction of T-cell hyporesponsiveness through chronic reactive oxygen species exposure.
GPx1 was found to play a critical role in regulating pro-inflammatory pathways in vascular endothelium.
Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE (显示 APOE 蛋白)- and ApoE (显示 APOE 蛋白)/GPx1-deficient mice.
Gpx1 expression in the mouse skeletal muscle can be altered by both exercise and dyslipidemia through changes in DNA methylation (显示 HELLS 蛋白), leading to a fine regulation of free radical metabolism.
there is no correlation between idiopathic male infertility and the GPx1 codon Pro198Leu polymorphism; further studies are needed to investigate other genetic factors that influence the development of idiopathic male infertility
Increased glutathione peroxidase (GPx) activity seemed to compensate for a decrease in GPx1 protein due to enhanced degradation via the proteasome. Mass spectrometry analysis identified Lys (显示 LYZ 蛋白)-114 as a possible carbonylation target which provides a vestibule for the substrate H2O2 and thus enhances the enzymatic reaction
ESR1 (显示 ESR1 蛋白) and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one.
The result of this study suggested that GPX1 Pro198Leu polymorphism could not be a risk factor for breast cancer in Rwanda.
No significant differences in allelic or genotypic frequencies of GPX1 rs1050450 or GSTP1 (显示 GSTP1 蛋白) rs1695 were detected between Chinese schizophrenia cases and controls.
Genetic variations in selenoprotein genes modulated both GPX1 and SELENOP selenoprotein gene expression and global gene expression in response to Brazil nut supplementation.
Allele-specific interaction between GPX1 and MnSOD (显示 SOD2 蛋白) affects the levels of Bcl2 (显示 BCL2 蛋白), Sirt3 (显示 SIRT3 蛋白) and E-cadherin (显示 CDH1 蛋白).
GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes
The Pro198Leu polymorphism (rs1050450) to the selenoprotein glutathione peroxidase 1 gene (GPX1), and GSTM1 (显示 GSTM1 蛋白) deletion had no effect on mercury levels in mildly exposed people, suggesting these genetic variants impact mercury levels only in highly exposed populations.
Evaluation of Glutathione Peroxidase and KCNJ11 (显示 KCNJ11 蛋白) Gene Polymorphisms in Patients with New Onset Diabetes Mellitus After Renal Transplantation
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
glutathione peroxidase Gpx1
, glutathione peroxidase
, cellular glutathione peroxidase
, cytosolic glutathione peroxidase
, putative glutathione peroxidase
, selenium-dependent glutathione peroxidase 1
, glutathione peroxidase 1
, glutathione peroxidase 1 S homeolog