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sLZIP is a novel co-repressor of ERalpha (显示 ESR1 蛋白), and plays a negative role in ERalpha (显示 ESR1 蛋白)-mediated cell proliferation in breast cancer
These findings indicate that LZIP is a novel modulator of APOA4 (显示 APOA4 蛋白) expression and hepatic lipid metabolism.
The authors found that the CREB3/Herp (显示 HERPUD1 蛋白) pathway limited the increase in cytosolic Ca2 (显示 CA2 蛋白)+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis.
The essential parts of the Golgi stress response from the perspective of the organelle autoregulation. The pathways of the mammalian Golgi stress response have been identified, specifically the CREB3 pathway.
These results indicate that sLZIP plays a role in expression of c-Jun (显示 JUN 蛋白), and migration and invasion of cervical cancer cells via regulation of MMP-9 (显示 MMP9 蛋白) transcription.
INHA (显示 INHA 蛋白) gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 (显示 TFAP2A 蛋白) regulates this expression by interacting with CRE.
Findings indicate that sLZIP negatively regulates AR transactivation in androgen-dependent PCa (显示 FLVCR1 蛋白) cells and functions as a positive regulator in tumor progression of androgen-independent PCa (显示 FLVCR1 蛋白). sLZIP contributes to the malignant phenotype of PCa (显示 FLVCR1 蛋白).
A CREB3-ARF4 (显示 ARF4 蛋白) signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity.
propose that JAB1 (显示 COPS5 蛋白) is a novel binding partner of Luman, which negatively regulates the activity of Luman by promoting its degradation
GSK3beta was downregulate in all samples and CREB3 did not show a significant decrease or increase in its mRNA expression, but the results were significant in mucoepidermoid carcinoma and salivary duct carcinoma.
LUMAN is a key regulator of glucocorticoid receptor (显示 NR3C1 蛋白)-mediated signaling.
Luman regulates mouse granulosa cell modulation of steroid synthesis, cell cycle activity and other regulators of folliculogenesis
LRF (显示 ZBTB7A 蛋白) seems to be involved in the regulation of decidualization during pregnancy.
These results suggest that Luman regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and intracellular distribution during osteoclastogenesis.
sLZIP is a novel PPARgamma2 (显示 PPARG 蛋白) modulator for control of the balance between adipogenesis and osteogenesis during Mesenchymal stem cell differentiation
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4 (显示 ACTN4 蛋白).
Luman might have important roles in embryo implantation and decidualization.
Luman recruiting factor (显示 CREBRF 蛋白) might be involved in inducing apoptosis of granulosa cells through the endoplasmic reticulum stress pathway in mice
Data show that ApoA4 (显示 APOA4 蛋白) is a true target gene of LUMAN in bone marrow-derived DCs (BMDCs).
Luman/CREB3 recruitment factor (显示 CREBRF 蛋白) inhibits Luman activation of the unfolded protein response
Tissue transcription analysis revealed that both porcine CREB2 (显示 ATF2 蛋白) and CREB3 mRNA were ubiquitously detected in all examined tissues.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
, basic leucine zipper protein
, cAMP-responsive element-binding protein 3
, cyclic AMP response element (CRE)-binding protein/activating transcription factor 1
, cyclic AMP-responsive element-binding protein 3
, leucin zipper proitein
, leucine zipper protein
, transcription factor LZIP-alpha
, transcription factor LZIP
, cAMP responsive element binding protein 3 (luman)
, cAMP responsive element-binding protein 3