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抗Mouse (Murine) POLE 抗体:
抗Human POLE 抗体:
抗Mustelid POLE 抗体:
Human Monoclonal POLE Primary Antibody for ICC, IF - ABIN151041
Maga, Jónsson, Stucki, Spadari, Hübscher: Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. in Journal of molecular biology 1999
Show all 13 Pubmed References
A missense mutation in Rev7 disrupts formation of Polzeta, impairing mouse development and repair of genotoxic agent-induced DNA lesions.
Findings distinguish Pol epsilon and delta functions in vivo and reveal tissue-specific requirements for DNA replication fidelity.
Data suggest that DNA polymerase epsilon catalytic subunit (POLE) mutation does not serve as a relevant biomarker and should not be tested on a regular basis in pancreatic ductal adenocarcinoma (PDAC).
These findings support a role for E2 beyond E1 recruitment in human papillomavirus 11 DNA replication, and further implicate cellular pol epsilon in viral DNA replication.
Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability
Mutation in DNA Polymerase II gene is associated with MMR deficiency in cancer.
Meta-analysis found that POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis.
This is the first study to functionally analyze a POLE genetic variant outside the exonuclease domain and widens the spectrum of genetic changes in this DNA polymerase that could lead to colorectal cancer predisposition.
Mutational analysis of hypermutation-related POLE gene in acute leukemias and lymphomas.
The basic biochemical mechanisms leading to a unique phenotype in POLE deficiency as well as challenges faced with interpreting the genomic profiling of tumors in this important subset of patients and the potential clinical implications will be discussed here
Data show that the POLE mutation leading to hypermutation can accelerate cancer development.
The POLE mutations have in selecting for mutations of the beta2 microglobulin (B2M) gene involved in antigen presentation.
POLE exonuclease domain mutations are prognostic markers associated with excellent outcomes for endometrial carcinoma patients.
Case Reports: POLE heterozygous mutations were found in two colorectal adenocarcinomas.
POLE mutations in tumors of women with grade 3 EEC are associated with a lower risk of recurrence and death, although not statistically significant because of high variability in these estimates.
Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours
We present the case of a patient with a left frontal glioblastoma with primitive neuroectodermal tumor features and hypermutated genotype in the setting of a POLE germline alteration
Hypermutation and elevated neoantigen count in glioblastoma occurred in a patient harboring a germline POLE mutation and are associated with a clinical and antitumor immune response to PD-1 blockade
Frameshift mutation in POLE gene is associated with mismatch repair-deficiency and Lynch syndrome.
Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.
POLE-mutated undifferentiated and dedifferentiated endometrial carcinomas were more frequently stage I tumors than similar carcinomas lacking exonuclease domain mutations (7/9; 78% vs. 3/12; 25%; P=0.023) and patients had significantly better outcome (disease-specific survival) than those without POLE exonuclease domain mutations (P=0.02)
Germline or somatic variants in the POLE/POLD1 were identified in unresolved suspected Lynch syndrome cancers with mismatch repair defect.
Participates in DNA repair and in chromosomal DNA replication.
DNA polymerase II subunit A
, DNA polymerase epsilon catalytic subunit A
, DNA-directed DNA polymerase epsilon