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抗Human HIST4H4 抗体:
抗Rat (Rattus) HIST4H4 抗体:
抗Mouse (Murine) HIST4H4 抗体:
ata show that PP32 and SET/TAF-Ibeta proteins block HAT1-mediated H4 acetylation.
Data suggest post-translational modifications of histones, trimethylation of lysine 36 in H3 (H3K36me3) and acetylation of lysine 16 in H4 (H4K16ac), have roles in DNA damage repair; H3K36me3 stimulates H4K16ac upon DNA double-strand break; SETD2 (显示 SETD2 抗体), LEDGF (显示 PSIP1 抗体), and KAT5 (显示 KAT5 抗体) are required for these epigenetic changes. (SETD2 (显示 SETD2 抗体) = SET domain containing 2 (显示 SETD2 抗体); LEDGF (显示 PSIP1 抗体) = lens epithelium-derived growth factor (显示 PSIP1 抗体); KAT5 (显示 KAT5 抗体) = lysine acetyltransferase 5 (显示 KAT5 抗体))
Data suggest that O-GlcNAc (显示 OGT 抗体) transferase 1 (OGT1) specifically binds to, O-GlcNAcylates, and stabilizes nonspecific lethal protein3 (NSL3 (显示 KANSL3 抗体)); stabilization of NSL3 (显示 KANSL3 抗体) by OGT1 up-regulates global acetylation levels of histone 4 at Lys-5 (显示 AASDHPPT 抗体), Lys (显示 LYZ 抗体)-8, and Lys (显示 LYZ 抗体)-16.
Data show that Omomyc protein co-localized with proto-oncogene (显示 RAB1A 抗体) protein c (显示 PROC 抗体)-myc (c-Myc (显示 MYC 抗体)), protein arginine methyltransferase 5 (PRMT5 (显示 PRMT5 抗体)) and histone H4 H4R3me2s-enriched chromatin domains.
H4K12ac is regulated by estrogen receptor-alpha (显示 ESR1 抗体) and is associated with BRD4 (显示 BRD4 抗体) function and inducible transcription
Systemic lupus erythematosus appears to be associated with an imbalance in histone acetyltransferases and histone deacetylase (显示 HDAC1 抗体) enzymes favoring pathologic H4 acetylation.
Data indicate that MEP50 (显示 WDR77 抗体) WD repeat protein (显示 DCAF7 抗体) is essential for methylation of histones H4 and H2A by PRMT5 (显示 PRMT5 抗体) arginine methyltransferase.
Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions.
Acetylation at lysine 5 of histone H4 associated with lytic gene promoters during reactivation of Kaposi's sarcoma-associated herpesvirus.
An increase in histone H4 acetylation caused by hypoxia in human neuroblastoma (显示 ARHGEF16 抗体) cell lines corresponds to increased levels of N-myc (显示 MYCN 抗体) transcription factor in these cells.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails\\\\; instead, they contain a palindromic termination element.
, histone 4, H4