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Data show that GEF Vav1 possesses tumor-suppressor functions in immature T cells.
Polymorphisms of VAV1 gene is associated with Rheumatoid arthritis.
Vav1 expression is increased in esophageal squamous cell carcinoma, indicates poor prognosis, and can serve as a candidate molecular prognostic marker.
TGFbeta (显示 TGFB1 ELISA试剂盒) induced the dissociation of DNMT1 (显示 DNMT1 ELISA试剂盒) from the VAV1 promoter, leading to demethylation and the subsequent ectopic expression of VAV1 in cancer cells via a SMAD4 (显示 SMAD4 ELISA试剂盒)-dependent mechanism
Our results suggest the existence of a Vav1/PU.1/miR (显示 MLXIP ELISA试剂盒)-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia (显示 PML ELISA试剂盒) -derived cells
revealed a new function for Vav1 in the negative feedback regulation of the phosphorylation of immunoreceptor tyrosine-based activation motifs within the zeta chains, CD3 delta (显示 CD3D ELISA试剂盒), epsilon, gamma chains, as well as activation sites on the critical T cell tyrosine kinases
Data indicate that only a single mutation in the proto-oncogene (显示 RAB1A ELISA试剂盒) Vav1 enhances tumorigenicity.
These findings establish VAV1 as a critical epigenetically regulated oncogene (显示 RAB1A ELISA试剂盒) with a key role in MBSHH maintenance, and highlight its potential as a validated therapeutic target and prognostic biomarker for the improved therapy of medulloblastoma.
The present study implies that estrogen-estrogen receptor (显示 ESR1 ELISA试剂盒) modulates the transcription and expression of Vav1, which may contribute to the proliferation of cancerous cells.
The role of Vav1 in T leukemia survival by selectively triggering Rac2 (显示 RAC2 ELISA试剂盒)-Akt (显示 AKT1 ELISA试剂盒) axis and elevating the expression of anti-apoptotic Bcl-2 (显示 BCL2 ELISA试剂盒).
this study reveals a novel function of Vav1 in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1 (显示 SIRT1 ELISA试剂盒).
Data show that GEF (显示 ARHGEF2 ELISA试剂盒) Vav1 possesses tumor-suppressor functions in immature T cells.
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 (显示 GRB2 ELISA试剂盒) stability
Vav1 adaptor has a role in the production of inflammatory cytokines by effector T cells and in the susceptibility to neuroinflammation
provide evidence that CD28 (显示 CD28 ELISA试剂盒) and the TCR complex regulate NF-kappaB (显示 NFKB1 ELISA试剂盒) via different signaling modules of GRB-2 (显示 GRB2 ELISA试剂盒)/VAV1 and LAT (显示 LAT ELISA试剂盒)/ADAP (显示 APP ELISA试剂盒) pathways respectively.
Platelet P-Rex and Vav family Rac (显示 AKT1 ELISA试剂盒)-GEFs play important proinflammatory roles in leukocyte recruitment.
The data show that vav1 not only affects transcription of the MHCII locus but also is an important regulator of MHCII protein transport to the cell surface.
analyses revealed a SHP2 (显示 PTPN11 ELISA试剂盒)- and Lyn (显示 LYN ELISA试剂盒)-dependent pathway leading to phosphorylation of Vav1, Rac (显示 AKT1 ELISA试剂盒) activation, and F-actin polymerization in SCF (显示 KITLG ELISA试剂盒)-treated BMMCs
Data indicate that Vav1 was a key negative regulator of macrophage-derived IL-6 (显示 IL6 ELISA试剂盒) production.
Bruton's Tyrosine Kinase (BTK (显示 BTK ELISA试剂盒)) and Vav1 contribute to Dectin1 (显示 CLEC7A ELISA试剂盒)-dependent phagocytosis of Candida albicans in macrophages.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
vav 1 oncogene
, proto-oncogene vav
, vav oncogene